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serpin family A member 5

Summary

Gene Symbol

SERPINA5

Organism

Homo sapiens (human)

External Links

NCBI Gene

5104

PubChem

5104

Alliance of Genome Resources

HGNC:8723

JoGo

SERPINA5

TogoVar

SERPINA5

Annotation

Keyword

3D-structure
Direct protein sequencing
Fertilization
Glycoprotein
Heparin-binding
Lipid transport
Proteomics identification
Reference proteome
Secreted
Serine protease inhibitor
Signal

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B4DDH1
P05154	Acrosomal serine protease inhibitor Plasminogen activator inhibitor 3 Protein C inhibitor Serpin A5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
lipid transport	IEA
spermatogenesis	ISS
fusion of sperm to egg plasma membrane involved in single fertilization	NAS	9510955
negative regulation of peptidase activity
negative regulation of hydrolase activity	IMP	8665956

GO Hierarchy

biological process

cellular process [inference]

cellular process involved in reproduction in multicellular organism [inference]

fusion of sperm to egg plasma membrane involved in single fertilization

cellular component organization or biogenesis [inference]

cellular component organization [inference]

membrane organization [inference]

plasma membrane organization [inference]

plasma membrane fusion [inference]

fusion of sperm to egg plasma membrane involved in single fertilization

membrane fusion [inference]

plasma membrane fusion [inference]

fusion of sperm to egg plasma membrane involved in single fertilization

reproductive process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

cellular process involved in reproduction in multicellular organism [inference]

fusion of sperm to egg plasma membrane involved in single fertilization

multicellular organismal reproductive process [inference]

gamete generation [inference]

male gamete generation [inference]

spermatogenesis

developmental process [inference]

developmental process involved in reproduction [inference]

spermatogenesis

localization [inference]

establishment of localization [inference]

transport [inference]

organic substance transport [inference]

lipid transport

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of macromolecule metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of proteolysis [inference]

negative regulation of peptidase activity

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity

negative regulation of peptidase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity [inference]

negative regulation of hydrolase activity

negative regulation of peptidase activity

regulation of hydrolase activity [inference]

negative regulation of hydrolase activity

negative regulation of peptidase activity

regulation of peptidase activity [inference]

negative regulation of peptidase activity

Displaying entries **11 - 15** of 23 in total

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GO Term	Evidence Code	PMID
protein C inhibitor-TMPRSS7 complex	IDA	15853774
protein C inhibitor-TMPRSS11E complex	IDA	15328353
protein C inhibitor-PLAT complex	IDA	10340997
protein C inhibitor-PLAU complex	IDA	10340997 3501295 8536714
protein C inhibitor-thrombin complex	IDA	6323392

GO Hierarchy

cellular component

protein-containing complex

peptidase inhibitor complex [inference]

protease inhibitor complex [inference]

serine protease inhibitor complex [inference]

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

acrosomal membrane

bounding membrane of organelle [inference]

secretory granule membrane [inference]

acrosomal membrane

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

platelet alpha granule

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

platelet dense tubular network

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

platelet alpha granule

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

platelet dense tubular network

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

platelet alpha granule

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

side of membrane [inference]

external side of plasma membrane

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
retinoic acid binding	IDA	11722589
protease binding	IPI	10340997 14696115 15853774 1725227 2844223 3501295 6323392 7521127 8665956 9556620
serine-type endopeptidase inhibitor activity	IDA	10340997 15853774 1725227 2844223 3501295 6323392 7521127 8536714 9510955 9556620
serine-type endopeptidase inhibitor activity	IBA
protein binding	IPI	24388360 7521127 8665956