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nitric oxide synthase interacting protein

Summary

Gene Symbol

NOSIP

Organism

Homo sapiens (human)

External Links

NCBI Gene

51070

PubChem

51070

Alliance of Genome Resources

HGNC:17946

Annotation

Keyword

3D-structure
Cytoplasm
Developmental protein
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Transferase
Ubl conjugation pathway

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A075B6F9
Q9Y314	E3 ubiquitin-protein ligase NOSIP RING-type E3 ubiquitin transferase NOSIP eNOS-interacting protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
negative regulation of catalytic activity	IDA	11149895
regulation of nitric oxide biosynthetic process	IMP	15548660
negative regulation of nitric-oxide synthase activity	IDA	11149895

GO Hierarchy

biological process

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of nitric oxide biosynthetic process

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of nitric oxide biosynthetic process

regulation of nitrogen compound metabolic process [inference]

regulation of nitric oxide metabolic process [inference]

regulation of nitric oxide biosynthetic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of nitric oxide biosynthetic process

regulation of molecular function [inference]

negative regulation of molecular function [inference]

negative regulation of catalytic activity

negative regulation of oxidoreductase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of nitric-oxide synthase activity

regulation of catalytic activity [inference]

negative regulation of catalytic activity

negative regulation of oxidoreductase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of nitric-oxide synthase activity

regulation of oxidoreductase activity [inference]

regulation of monooxygenase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of nitric-oxide synthase activity

regulation of nitric-oxide synthase activity [inference]

negative regulation of nitric-oxide synthase activity

negative regulation of oxidoreductase activity [inference]

negative regulation of monooxygenase activity [inference]

negative regulation of nitric-oxide synthase activity

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleoplasm	IDA
Golgi membrane	TAS
nucleus	IBA IDA	15548660
cytosol	TAS
cytoplasm	IDA	15548660

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	11149895 32296183
ubiquitin protein ligase activity	IEA
RNA binding	HDA	22658674
molecular sequestering activity	IPI	15548660

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

aminoacyltransferase activity [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

catalytic activity, acting on a protein [inference]

ubiquitin-like protein transferase activity [inference]

ubiquitin-protein transferase activity [inference]

ubiquitin protein ligase activity

ubiquitin-like protein ligase activity [inference]

ubiquitin protein ligase activity

binding [inference]

protein binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

molecular sequestering activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Nitric oxide synthase-interacting protein

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 4** entries
InterPro
Nitric oxide synthase-interacting protein, zinc-finger
Nitric oxide synthase-interacting protein
Zinc finger, RING-type
Zinc finger, RING/FYVE/PHD-type

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:4621	holoprosencephaly	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 66 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	32819		FB:FBgn0030915
Mus musculus	66394		MGI:1913644	MOUSE53793
Caenorhabditis elegans	177526		WB:WBGene00019898
Rattus norvegicus	292894		RGD:1309992	RATNO16150
Xenopus tropicalis	394625		Xenbase:XB-GENE-945889
Xenopus laevis	414557		Xenbase:XB-GENE-945894
Pan troglodytes	456209	9598_0:004e12		PANTR18931
Danio rerio	492793		ZFIN:ZDB-GENE-041114-146	DANRE31354
Bos taurus	511234			BOVIN11531
Macaca mulatta	718888			MACMU19245

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Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements