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ER degradation enhancing alpha-mannosidase like protein 1

Summary

Gene Symbol

EDEM1

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 511008
KEGG Gene ID: bta:511008
PubChem: 511008

Annotation

Keyword

Calcium
Endoplasmic reticulum
Glycosidase
Metal-binding
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
A7YY48

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
mannose trimming involved in glycoprotein ERAD pathway	IEA	30032202
endoplasmic reticulum mannose trimming	IEA	30032202
carbohydrate metabolic process	IEA	22301074

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

primary metabolic process [inference]

carbohydrate metabolic process

protein metabolic process [inference]

glycoprotein metabolic process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

organic substance metabolic process [inference]

carbohydrate metabolic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

macromolecule modification [inference]

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

carbohydrate derivative metabolic process [inference]

glycoprotein metabolic process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

glycoprotein metabolic process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

protein modification process [inference]

protein deglycosylation [inference]

protein deglycosylation involved in glycoprotein catabolic process [inference]

mannose trimming involved in glycoprotein ERAD pathway

protein demannosylation [inference]

protein alpha-1,2-demannosylation [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
membrane	IEA	22301074
endoplasmic reticulum	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

Displaying **all 2** entries
GO Term	Evidence Code	PMID
calcium ion binding	IEA	22301074
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

mannosidase activity [inference]

alpha-mannosidase activity [inference]

mannosyl-oligosaccharide mannosidase activity [inference]

mannosyl-oligosaccharide 1,2-alpha-mannosidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Mannosyl-oligosaccharide

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
calcium ion binding
hydrolase activity, acting on glycosyl bonds
hydrolase activity
mannosyl-oligosaccharide 1,2-alpha-mannosidase activity
metal ion binding

Displaying **all 3** entries
InterPro
Glycoside hydrolase family 47
Seven-hairpin glycosidases
Six-hairpin glycosidase-like superfamily

KEGG BRITE Database

Orthology

K10084

Name

ER degradation enhancer, mannosidase alpha-like 1

References

19524542

Ortholog

Displaying entries **11 - 20** of 84 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Taeniopygia guttata	100223330		TAEGU03560
Callithrix jacchus	100388997		CALJA12093
Pongo abelii	100445530		PONAB26828
Anolis carolinensis	100567845		ANOCA03632
Nomascus leucogenys	100603542		NOMLE19785
Oreochromis niloticus	100706028		ORENI60282
Cavia porcellus	100714413		CAVPO09143
Sus scrofa	100738285	9823_0:003889	PIGXX04500
Otolemur garnettii	100963273		OTOGA15589
Papio anubis	101015887		PAPAN24465