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aph-1 homolog A, gamma-secretase subunit

Summary

Gene Symbol

APH1A

Organism

Homo sapiens (human)

External Links

NCBI Gene

51107

PubChem

51107

Alliance of Genome Resources

HGNC:29509

JoGo

APH1A

TogoVar

APH1A

Annotation

Keyword

3D-structure
Alternative splicing
Endoplasmic reticulum
Golgi apparatus
Notch signaling pathway
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
B4DUG7
Q96BI3	Aph-1alpha Presenilin-stabilization factor

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 25 in total

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GO Term	Evidence Code	PMID
metanephros development	IEA
membrane protein ectodomain proteolysis	IDA	15274632
Notch signaling pathway	IBA
Notch receptor processing	NAS	10206645
Notch receptor processing	TAS	15274632

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process [inference]

amyloid-beta formation

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process [inference]

amyloid-beta formation

protein metabolic process [inference]

proteolysis [inference]

protein processing

membrane protein proteolysis [inference]

Notch receptor processing

amyloid precursor protein metabolic process

amyloid precursor protein catabolic process

amyloid-beta formation

protein maturation [inference]

protein processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

membrane protein proteolysis [inference]

Notch receptor processing

amyloid precursor protein metabolic process

amyloid precursor protein catabolic process

amyloid-beta formation

protein maturation [inference]

protein processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

membrane protein proteolysis [inference]

Notch receptor processing

amyloid precursor protein metabolic process

amyloid precursor protein catabolic process

amyloid-beta formation

protein maturation [inference]

protein processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

amyloid-beta metabolic process [inference]

amyloid-beta formation

protein metabolic process [inference]

proteolysis [inference]

protein processing

membrane protein proteolysis [inference]

Notch receptor processing

amyloid precursor protein metabolic process

amyloid precursor protein catabolic process

amyloid-beta formation

protein maturation [inference]

protein processing

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

kidney development [inference]

metanephros development

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of proteolysis [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of hydrolase activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of peptidase activity [inference]

positive regulation of peptidase activity [inference]

positive regulation of endopeptidase activity

regulation of endopeptidase activity [inference]

positive regulation of endopeptidase activity

Displaying entries **6 - 10** of 19 in total

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GO Term	Evidence Code	PMID
Golgi apparatus	IDA	15274632
plasma membrane	ISS
plasma membrane	TAS
plasma membrane	IDA	15274632
synaptic vesicle	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

plasma membrane protein complex [inference]

gamma-secretase complex

catalytic complex [inference]

gamma-secretase complex

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

Golgi cisterna membrane

bounding membrane of organelle [inference]

plasma membrane region [inference]

synaptic membrane [inference]

presynaptic membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

endosome [inference]

early endosome

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	12297508 18201567 19376115 25394380 26280335 30559186 32296183 32814053
enzyme binding	IEA
protein-macromolecule adaptor activity	IMP	12297508
protein-macromolecule adaptor activity	IBA
endopeptidase activator activity	IMP	12297508