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retinol dehydrogenase 11

Summary

Gene Symbol

RDH11

Organism

Homo sapiens (human)

External Links

NCBI Gene

51109

PubChem

51109

Alliance of Genome Resources

HGNC:17964

Annotation

Keyword

Acetylation
Alternative splicing
Cataract
Dwarfism
Endoplasmic reticulum
Lipid metabolism
NADP
Oxidoreductase
Reference proteome
Signal
Signal-anchor
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
A0A0S2Z583
Q8TC12	Androgen-regulated short-chain dehydrogenase/reductase 1 HCV core-binding protein HCBP12 Prostate short-chain dehydrogenase/reductase 1 Retinal reductase 1 Short chain dehydrogenase/reductase family 7C member 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cellular detoxification of aldehyde	IDA	12807874
retinoid metabolic process	IDA TAS	12226107
retinal metabolic process	IDA	12807874
retinol metabolic process	IEA ISS
visual perception	IEA

GO Hierarchy

biological process

metabolic process [inference]

hormone metabolic process [inference]

retinol metabolic process

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

retinal metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

organic substance metabolic process [inference]

cellular aldehyde metabolic process [inference]

retinal metabolic process

lipid metabolic process [inference]

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

olefinic compound metabolic process [inference]

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

primary alcohol metabolic process [inference]

retinol metabolic process

cellular process [inference]

cellular metabolic process [inference]

cellular aldehyde metabolic process [inference]

retinal metabolic process

cellular lipid metabolic process [inference]

isoprenoid metabolic process [inference]

terpenoid metabolic process [inference]

diterpenoid metabolic process [inference]

retinoid metabolic process

cellular detoxification [inference]

cellular detoxification of aldehyde

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of light stimulus [inference]

visual perception

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

retinol metabolic process

detoxification [inference]

cellular detoxification [inference]

cellular detoxification of aldehyde

Displaying **all 2** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IDA TAS	12807874
photoreceptor inner segment	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

photoreceptor inner segment

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
protein binding	IPI	28514442 29410696 33961781
NAD-retinol dehydrogenase activity	ISS TAS
NADP-retinol dehydrogenase activity	IDA TAS	12226107 12807874
oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	TAS
aldehyde dehydrogenase (NADP+) activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor

aldo-keto reductase (NADP) activity [inference]

alcohol dehydrogenase (NADP+) activity [inference]

NADP-retinol dehydrogenase activity

oxidoreductase activity, acting on the aldehyde or oxo group of donors [inference]

oxidoreductase activity, acting on the aldehyde or oxo group of donors, NAD or NADP as acceptor [inference]

aldehyde dehydrogenase [NAD(P)+] activity [inference]

aldehyde dehydrogenase (NADP+) activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Oxidoreductase

Functional Category

C: Energy production and conversion
I: Lipid transport and metabolism
T: Signal transduction mechanisms

Displaying 1 entry
Gene Ontology
oxidoreductase activity

Displaying **all 2** entries
InterPro
NAD(P)-binding domain superfamily
Short-chain dehydrogenase/reductase SDR

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:14791	Leber congenital amaurosis	Alliance of Genome Resources

Ortholog

Displaying entries **51 - 60** of 74 in total

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Species	Gene ID	Orthologous MAtrix
Cercocebus atys	105582866	CERAT26417
Aotus nancymaae	105707185	AOTNA14880
Propithecus coquereli	105819841	PROCO01224
Dipodomys ordii	105986545	DIPOR01888
Salmo salar	106611488	SALSA142756
Sinocyclocheilus grahami	107585486	SINGR36257
Sinocyclocheilus grahami	107588583	SINGR12099
Ictalurus punctatus	108263330	ICTPU27574
Cebus imitator	108284205	CEBIM04859
Cebus imitator	108284224	CEBIM04859

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OrthoDB (Group)

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Acknowledgements