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Guidelines

MIRAGE

COP9 signalosome subunit 4

Summary

Gene Symbol

COPS4

Organism

Homo sapiens (human)

External Links

NCBI Gene

51138

PubChem

51138

Alliance of Genome Resources

HGNC:16702

JoGo

COPS4

TogoVar

COPS4

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Cytoplasm
Cytoplasmic vesicle
Direct protein sequencing
Nucleus
Proteomics identification
Reference proteome
Signalosome
Synapse

Proteins

Displaying **all 4** entries
UniProt	Protein Name
A0A0S2Z5H7
B3KM48
D6RAX7
Q9BT78	JAB1-containing signalosome subunit 4

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein deneddylation	IDA	19141280
protein deneddylation	IMP	21102408
protein neddylation	NAS	24421388
regulation of protein neddylation	NAS	24421388

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein neddylation

protein modification by small protein removal [inference]

protein deneddylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein neddylation

protein modification by small protein removal [inference]

protein deneddylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein neddylation

protein modification by small protein removal [inference]

protein deneddylation

macromolecule modification [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein neddylation

protein modification by small protein removal [inference]

protein deneddylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

post-translational protein modification [inference]

protein modification by small protein conjugation or removal [inference]

protein modification by small protein conjugation [inference]

protein neddylation

protein modification by small protein removal [inference]

protein deneddylation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of nitrogen compound metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of post-translational protein modification [inference]

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein neddylation

regulation of macromolecule metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of post-translational protein modification [inference]

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein neddylation

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of post-translational protein modification [inference]

regulation of protein modification by small protein conjugation or removal [inference]

regulation of protein neddylation

Displaying entries **1 - 5** of 14 in total

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GO Term	Evidence Code	PMID
nucleus	ISS
nucleus	IDA	24421388
nucleus	HDA	21630459
nucleoplasm	TAS
cytoplasm	ISS

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

COP9 signalosome

cellular anatomical entity [inference]

nuclear body [inference]

nuclear speck

cell junction

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

secretory vesicle [inference]

exocytic vesicle [inference]

synaptic vesicle

Displaying **all 2** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16189514 19615732 20195357 21102408 21145461 25043011 25416956 25852190 26030138 26871637 28514442 32296183 32707033 32814053 33961781 34591612
deNEDDylase activity	TAS

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

ubiquitin-like protein peptidase activity [inference]

deNEDDylase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

ubiquitin-like protein peptidase activity [inference]

deNEDDylase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Signalosome subunit 4

Functional Category

G: Carbohydrate transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 4** entries
InterPro
26S Proteasome non-ATPase regulatory subunit 12/COP9 signalosome complex subunit 4
Proteasome component (PCI) domain
Winged helix DNA-binding domain superfamily
Winged helix-like DNA-binding domain superfamily

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025