GlyCosmos Portal

Submissions

cytochrome b5 reductase 4

Summary

Gene Symbol

CYB5R4

Aliases

b5+b5R
dJ676J13.1

Organism

Homo sapiens (human)

External Links

NCBI Gene

51167

HGNC

20147

KEGG Gene ID

hsa:51167

PubChem

51167

Alliance of Genome Resources

HGNC:20147

Annotation

Keyword

3D-structure
Acetylation
Endoplasmic reticulum
FAD
Heme
NAD
Oxidoreductase
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
Q7L1T6	Flavohemoprotein b5/b5R N-terminal cytochrome b5 and cytochrome b5 oxidoreductase domain-containing protein cb5/cb5R

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
reactive oxygen species metabolic process	IDA	15131110
cell development	ISS
superoxide metabolic process	IBA IDA	10611283
insulin secretion	ISS
bicarbonate transport

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

reactive oxygen species metabolic process

superoxide metabolic process

cellular process [inference]

cellular metabolic process [inference]

reactive oxygen species metabolic process

superoxide metabolic process

cellular developmental process [inference]

cell development

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

developmental process [inference]

anatomical structure development [inference]

cell development

cellular developmental process [inference]

cell development

homeostatic process [inference]

chemical homeostasis [inference]

carbohydrate homeostasis [inference]

glucose homeostasis

response to stimulus [inference]

response to abiotic stimulus [inference]

response to oxygen levels [inference]

detection of oxygen

response to chemical [inference]

response to antibiotic

detection of stimulus [inference]

detection of chemical stimulus [inference]

detection of oxygen

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

establishment of localization [inference]

transport [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

secretion [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

organic substance transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

organic anion transport [inference]

bicarbonate transport

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

one-carbon compound transport [inference]

bicarbonate transport

nitrogen compound transport [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

amide transport [inference]

peptide transport [inference]

peptide secretion [inference]

peptide hormone secretion [inference]

insulin secretion

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

insulin secretion

signal release [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

insulin secretion

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

insulin secretion

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone transport [inference]

hormone secretion [inference]

peptide hormone secretion [inference]

insulin secretion

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endoplasmic reticulum	IBA IDA	15131110
cytoplasm	IBA
endoplasmic reticulum membrane
perinuclear region of cytoplasm	IDA	10611283

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytoplasm

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

endoplasmic reticulum

perinuclear region of cytoplasm

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytochrome-b5 reductase activity, acting on NAD(P)H	IBA IDA TAS	10611283
NAD(P)H oxidase H2O2-forming activity	IDA	10611283 15131110
metal ion binding	IEA
heme binding	IBA
oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor	IDA	15131110

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on NAD(P)H [inference]

oxidoreductase activity, acting on NAD(P)H, heme protein as acceptor

cytochrome-b5 reductase activity, acting on NAD(P)H

oxidoreductase activity, acting on NAD(P)H, oxygen as acceptor [inference]

NAD(P)H oxidase H2O2-forming activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

tetrapyrrole binding [inference]

heme binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000065615

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00326

Name

cytochrome-b5 reductase [EC:1.6.2.2]

References

10611283

Rhea

RHEA:46680

NADH

H⁺ + NAD⁺

Enzyme

1.6.2.2

PMID

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0050524	maturity-onset diabetes of the young	DisGeNET
DOID:10603	glucose intolerance	DisGeNET
DOID:11714	gestational diabetes	DisGeNET
DOID:11716	prediabetes syndrome	DisGeNET
DOID:1612	breast cancer	DisGeNET
DOID:1837	diabetic ketoacidosis	DisGeNET
DOID:9351	diabetes mellitus	DisGeNET DisGeNET
DOID:9352	type 2 diabetes mellitus	DisGeNET DisGeNET Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 85 in total

1

2

3

4

5

…

Next ›

Last »
Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	37227	FB:FBgn0034442
Latimeria chalumnae	102349279		LATCH14267
Lepisosteus oculatus	102684306		LEPOC00739
Danio rerio	553685	ZFIN:ZDB-GENE-050522-225	DANRE11632
Astyanax mexicanus	103046158		ASTMX05746
Ictalurus punctatus	108269273		ICTPU14213
Electrophorus electricus	113581109		ELEEL03327
Salmo salar	106579451		SALSA106078
Salmo salar	106605501		SALSA123217
Salmo trutta	115176415		SALTR84165

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

International Collaboration

Acknowledgements