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myosin XVA

Summary

Gene Symbol

MYO15A

Organism

Homo sapiens (human)

External Links

NCBI Gene

51168

PubChem

51168

Alliance of Genome Resources

HGNC:7594

Annotation

Keyword

3D-structure
ATP-binding
Actin-binding
Alternative splicing
Calmodulin-binding
Cell projection
Coiled coil
Cytoskeleton
Disease variant
Hearing
Myosin
Non-syndromic deafness
Reference proteome
Repeat
SH3 domain

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UKN7	Unconventional myosin-15

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
sensory perception of sound	IEA
endocytosis	IBA
inner ear morphogenesis	IEA
locomotory behavior	IEA
actin filament organization	IBA

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

supramolecular fiber organization [inference]

actin filament organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

behavior [inference]

locomotory behavior

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

inner ear morphogenesis

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

import into cell [inference]

endocytosis

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
membrane	IBA
myosin complex	IEA
actin-based cell projection	IBA
stereocilium	IEA
actin cytoskeleton	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

myosin complex

cellular anatomical entity [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

stereocilium

actin-based cell projection

stereocilium

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
microfilament motor activity	IBA
actin filament binding	IBA
calmodulin binding	IEA
ATP binding	IEA

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microfilament motor activity

binding [inference]

protein binding [inference]

calmodulin binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

actin filament binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microfilament motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

myosin

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
ATP binding
actin binding
cytoskeletal motor activity
nucleotide binding

Displaying **all 2** entries
InterPro
MyTH4 domain superfamily
MyTH4 domain

Disease

Disease Ontology

Displaying **all 3** entries
DO ID	Disease Name	Source
DOID:0110488	autosomal recessive nonsyndromic deafness 3	Alliance of Genome Resources
DOID:10003	sensorineural hearing loss	Alliance of Genome Resources
DOID:1432	blindness	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 38 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	17910		MGI:1261811	MOUSE03958
Drosophila melanogaster	32028		FB:FBgn0263705
Rattus norvegicus	501699		RGD:1561873	RATNO00960
Danio rerio	560592		ZFIN:ZDB-GENE-080425-2
Danio rerio	570113		ZFIN:ZDB-GENE-090312-149
Macaca mulatta	700077			MACMU14018
Pongo abelii	100441879	9601_0:00413f		PONAB11541
Nomascus leucogenys	100600019			NOMLE08163
Loxodonta africana	100668953			LOXAF03346
Sarcophilus harrisii	100926197			SARHA08584

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024