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Guidelines

MIRAGE

myosin XVA

Summary

Gene Symbol

MYO15A

Organism

Homo sapiens (human)

External Links

NCBI Gene

51168

PubChem

51168

Alliance of Genome Resources

HGNC:7594

Annotation

Keyword

3D-structure
ATP-binding
Actin-binding
Alternative splicing
Calmodulin-binding
Cell projection
Coiled coil
Cytoskeleton
Disease variant
Hearing
Myosin
Non-syndromic deafness
Reference proteome
Repeat
SH3 domain

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9UKN7	Unconventional myosin-15

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
endocytosis	IBA
actin filament organization	IBA
sensory perception of sound	IEA
locomotory behavior	IEA
response to light stimulus	IEA

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

supramolecular fiber organization [inference]

actin filament organization

multicellular organismal process [inference]

system process [inference]

nervous system process [inference]

sensory perception [inference]

sensory perception of mechanical stimulus [inference]

sensory perception of sound

behavior [inference]

locomotory behavior

developmental process [inference]

anatomical structure morphogenesis [inference]

embryonic morphogenesis [inference]

inner ear morphogenesis

response to stimulus [inference]

response to abiotic stimulus [inference]

response to radiation [inference]

response to light stimulus

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

import into cell [inference]

endocytosis

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cytoplasm	IBA
actin cytoskeleton	IBA
membrane	IBA
myosin complex	IEA
stereocilium	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

myosin complex

cellular anatomical entity [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection [inference]

stereocilium

actin-based cell projection

stereocilium

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

non-membrane-bounded organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

intracellular organelle [inference]

intracellular non-membrane-bounded organelle [inference]

cytoskeleton [inference]

actin cytoskeleton

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 4** entries
GO Term	Evidence Code	PMID
microfilament motor activity	IBA
calmodulin binding	IEA
ATP binding	IEA
actin filament binding	IBA

GO Hierarchy

molecular function

cytoskeletal motor activity [inference]

microfilament motor activity

binding [inference]

protein binding [inference]

calmodulin binding

cytoskeletal protein binding [inference]

actin binding [inference]

actin filament binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

protein-containing complex binding [inference]

actin filament binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

microfilament motor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

myosin

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
ATP binding
cytoskeletal motor activity

Displaying **all 2** entries
InterPro
MyTH4 domain superfamily
MyTH4 domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0110488	autosomal recessive nonsyndromic deafness 3	Alliance of Genome Resources
DOID:10003	sensorineural hearing loss	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 31 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	17910		MOUSE03958
Caenorhabditis elegans	23026	WB:WBGene00002037
Xenopus laevis	51168	Xenbase:XB-GENE-17342403
Rattus norvegicus	501699		RATNO00960
Macaca mulatta	700077		MACMU14018
Pongo abelii	100441879		PONAB11541
Nomascus leucogenys	100600019		NOMLE08163
Loxodonta africana	100668953		LOXAF03346
Sarcophilus harrisii	100926197		SARHA08584
Otolemur garnettii	100967199		OTOGA10787

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025