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proprotein convertase subtilisin/kexin type 5

Summary

Gene Symbol

PCSK5

Organism

Homo sapiens (human)

External Links

NCBI Gene

5125

PubChem

5125

Alliance of Genome Resources

HGNC:8747

Annotation

Keyword

Alternative splicing
Cleavage on pair of basic residues
Glycoprotein
Pregnancy
Reference proteome
Repeat
Secreted
Serine protease
Signal
Transmembrane helix
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
Q92824	Proprotein convertase 5 Proprotein convertase 6 Subtilisin/kexin-like protease PC5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 17 in total

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GO Term	Evidence Code	PMID
anterior/posterior pattern specification	IMP	18519639
renin secretion into blood stream	IEP	8901832
embryonic digestive tract development	IMP ISS	18519639 8940009
embryo implantation	ISS	8940009
protein processing	IDA	15606899 8901832

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

amide metabolic process [inference]

peptide metabolic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signal peptide processing

signaling receptor ligand precursor processing [inference]

protein maturation [inference]

protein processing

signal peptide processing

signaling receptor ligand precursor processing [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

organic substance biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

hormone metabolic process [inference]

peptide hormone processing

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signal peptide processing

signaling receptor ligand precursor processing [inference]

protein maturation [inference]

protein processing

signal peptide processing

signaling receptor ligand precursor processing [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signal peptide processing

signaling receptor ligand precursor processing [inference]

protein maturation [inference]

protein processing

signal peptide processing

signaling receptor ligand precursor processing [inference]

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing

signal peptide processing

signaling receptor ligand precursor processing [inference]

protein maturation [inference]

protein processing

signal peptide processing

signaling receptor ligand precursor processing [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

organic substance biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

cellular process [inference]

cell communication [inference]

cell-cell signaling

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-containing complex remodeling [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling

protein-lipid complex organization [inference]

protein-lipid complex remodeling [inference]

plasma lipoprotein particle remodeling

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

renin secretion into blood stream

signal release [inference]

renin secretion into blood stream

viral process [inference]

viral life cycle

reproductive process [inference]

embryo implantation

multicellular organismal process [inference]

pattern specification process [inference]

regionalization [inference]

anterior/posterior pattern specification

plasma lipoprotein particle organization [inference]

plasma lipoprotein particle remodeling

developmental process [inference]

anatomical structure morphogenesis [inference]

appendage morphogenesis [inference]

limb morphogenesis

anatomical structure development [inference]

tube development [inference]

respiratory tube development

digestive tract development [inference]

embryonic digestive tract development

animal organ development [inference]

embryonic organ development [inference]

embryonic digestive tract development

system development [inference]

skeletal system development [inference]

embryonic skeletal system development

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

establishment of localization [inference]

transport [inference]

secretion [inference]

secretion by cell [inference]

protein secretion [inference]

renin secretion into blood stream

signal release [inference]

renin secretion into blood stream

organic substance transport [inference]

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

nitrogen compound transport [inference]

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

export from cell [inference]

secretion by cell [inference]

protein secretion [inference]

renin secretion into blood stream

signal release [inference]

renin secretion into blood stream

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

cellular localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

establishment of protein localization [inference]

protein transport [inference]

protein secretion [inference]

renin secretion into blood stream

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

protein localization to extracellular region [inference]

establishment of protein localization to extracellular region [inference]

protein secretion [inference]

renin secretion into blood stream

biological regulation [inference]

regulation of biological process [inference]

signaling [inference]

cell-cell signaling

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
trans-Golgi network	IBA
extracellular space	ISS	8940009
extracellular region	TAS
Golgi lumen	TAS
Golgi membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

bounding membrane of organelle [inference]

Golgi membrane

membrane-enclosed lumen [inference]

organelle lumen [inference]

intracellular organelle lumen [inference]

Golgi lumen

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

trans-Golgi network

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Golgi apparatus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
endopeptidase activity	EXP	16109723 20581395
peptidase activity	IDA	15606899
protein binding	IPI	25416956 32296183
peptide binding	ISS	8940009
serine-type endopeptidase activity	IBA IDA	8901832

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding

amide binding [inference]

peptide binding

Gene Ontology information from NCBI Gene and UniProt.

Disease

Disease Ontology

Displaying **all 5** entries
DO ID	Disease Name	Source
DOID:0050545	visceral heterotaxy	Alliance of Genome Resources
DOID:11446	sciatic neuropathy	Alliance of Genome Resources
DOID:14679	VACTERL association	Alliance of Genome Resources
DOID:234	colon adenocarcinoma	Alliance of Genome Resources
DOID:9562	primary ciliary dyskinesia	Alliance of Genome Resources