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Guidelines

MIRAGE

proprotein convertase subtilisin/kexin type 2

Summary

Gene Symbol

PCSK2

Organism

Homo sapiens (human)

External Links

NCBI Gene

5126

PubChem

5126

Alliance of Genome Resources

HGNC:8744

Annotation

Keyword

Alternative splicing
Cleavage on pair of basic residues
Cytoplasmic vesicle
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Serine protease
Signal
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
P16519	KEX2-like endoprotease 2 Prohormone convertase 2 Proprotein convertase 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
proteolysis	IDA	7626024
nervous system development	IEA
peptide hormone processing	IDA	28719828
peptide hormone processing	IBA
protein autoprocessing	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin metabolic process [inference]

insulin processing

hormone metabolic process [inference]

peptide hormone processing

primary metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin metabolic process [inference]

insulin processing

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin metabolic process [inference]

insulin processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

peptide hormone processing

protein metabolic process [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

protein maturation [inference]

protein processing [inference]

protein autoprocessing

signaling receptor ligand precursor processing [inference]

peptide hormone processing

insulin metabolic process [inference]

insulin processing

developmental process [inference]

anatomical structure development [inference]

system development [inference]

nervous system development

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
extracellular space	IDA	28719828 9020868
extracellular space	IBA
nucleoplasm	IDA
membrane	IDA	8034613
membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cell projection [inference]

plasma membrane bounded cell projection [inference]

neuron projection

dendrite

perikaryon

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

secretory vesicle [inference]

secretory granule

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

secretory vesicle [inference]

secretory granule

intracellular organelle [inference]

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

transport vesicle

secretory vesicle [inference]

secretory granule

Displaying **all 3** entries
GO Term	Evidence Code	PMID
serine-type endopeptidase activity	IDA	7626024
serine-type endopeptidase activity	IBA
protein binding	IPI	32814053 7913882

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Proprotein convertase subtilisin/kexin type

Functional Category

E: Amino acid transport and metabolism
Q: Secondary metabolites biosynthesis, transport and catabolism
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
hydrolase activity
peptide hormone processing
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Displaying **all 8** entries
InterPro
Galactose-binding-like domain superfamily
Kexin/furin catalytic domain
P domain
Peptidase S8, subtilisin, His-active site
Peptidase S8, subtilisin, Ser-active site
Peptidase S8, subtilisin-related
Peptidase S8/S53 domain superfamily
Peptidase S8/S53 domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:5844	myocardial infarction	Alliance of Genome Resources
DOID:9352	type 2 diabetes mellitus	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 78 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	5126	Xenbase:XB-GENE-960013
Mus musculus	18549	Xenbase:XB-GENE-960013	MOUSE35600
Rattus norvegicus	25121	Xenbase:XB-GENE-960013	RATNO26436
Xenopus tropicalis	43215	Xenbase:XB-GENE-960013
Xenopus tropicalis	179412	Xenbase:XB-GENE-960013
Bos taurus	281968		BOVIN04526
Sus scrofa	445533		PIGXX11301
Pan troglodytes	458106		PANTR24399
Canis lupus familiaris	485757		CANLF09277
Macaca mulatta	695730		MACMU02549

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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GlyCosmos Portal v4.4.0

Last updated: December 8, 2025