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7-dehydrocholesterol reductase

Summary

Gene Symbol

DHCR7

Organism

Bos taurus (cattle)

External Links

NCBI Gene: 514745
KEGG Gene ID: bta:514745
PubChem: 514745

Annotation

Keyword

Cholesterol biosynthesis
Endoplasmic reticulum
NADP
Oxidoreductase
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5E9J5	Sterol Delta(7)-reductase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cholesterol biosynthetic process	IEA	30032202
brassinosteroid biosynthetic process	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

hormone metabolic process [inference]

brassinosteroid metabolic process [inference]

brassinosteroid biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid metabolic process [inference]

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

brassinosteroid metabolic process [inference]

brassinosteroid biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid metabolic process [inference]

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

brassinosteroid metabolic process [inference]

brassinosteroid biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid metabolic process [inference]

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

brassinosteroid metabolic process [inference]

brassinosteroid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid metabolic process [inference]

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

brassinosteroid metabolic process [inference]

brassinosteroid biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

phytosteroid biosynthetic process [inference]

brassinosteroid biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

brassinosteroid metabolic process [inference]

brassinosteroid biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying 1 entry
GO Term	Evidence Code	PMID
7-dehydrocholesterol reductase activity	IEA	30032202

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on the CH-CH group of donors [inference]

oxidoreductase activity, acting on the CH-CH group of donors, NAD or NADP as acceptor [inference]

7-dehydrocholesterol reductase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K00213

Name

7-dehydrocholesterol reductase [EC:1.3.1.21]

References

9465114

Rhea

cholesterol + NADP⁺

H⁺ + 7-dehydrocholesterol + NADPH

Enzyme

1.3.1.21

PMID

Ortholog

Displaying entries **21 - 30** of 82 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Papio anubis	101010909		PAPAN06753
Mandrillus leucophaeus	105545304		MANLE26358
Gorilla gorilla gorilla	101137517		GORGO03111
Pan paniscus	100977099		PANPA07383
Pan troglodytes	451393		PANTR03683
Homo sapiens	1717		HUMAN07828
Canis lupus familiaris	483675		CANLF05936
Vulpes vulpes	112924153		VULVU17734
Ursus americanus	123778362		URSAM00991
Ailuropoda melanoleuca	100467495		AILME09761

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: August 19, 2024