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hydroxysteroid 17-beta dehydrogenase 7

Summary

Gene Symbol

HSD17B7

Aliases

PRAP
SDR37C1
short chain dehydrogenase/reductase family 37C, member 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

51478

HGNC

5215

KEGG Gene ID

hsa:51478

PubChem

51478

Alliance of Genome Resources

HGNC:5215

Annotation

Keyword

Alternative splicing
Endoplasmic reticulum
Glycoprotein
NAD
NADP
Oxidoreductase
Reference proteome
Steroid biosynthesis
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9H9C0
P56937	17-beta-hydroxysteroid dehydrogenase 7 3-keto-steroid reductase Dihydrotestosterone oxidoreductase Estradiol 17-beta-dehydrogenase 7 Short chain dehydrogenase/reductase family 37C member 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cholesterol biosynthetic process	IBA IDA TAS	12829805
estrogen biosynthetic process	IDA IEA	12732193
androgen metabolic process	IDA	12732193

GO Hierarchy

biological process

metabolic process [inference]

biosynthetic process [inference]

hormone biosynthetic process [inference]

estrogen biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

hormone metabolic process [inference]

androgen metabolic process

estrogen metabolic process [inference]

estrogen biosynthetic process

hormone biosynthetic process [inference]

estrogen biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

androgen metabolic process

estrogen metabolic process [inference]

estrogen biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

small molecule metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

small molecule biosynthetic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

androgen metabolic process

estrogen metabolic process [inference]

estrogen biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

organic cyclic compound metabolic process [inference]

steroid metabolic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

androgen metabolic process

estrogen metabolic process [inference]

estrogen biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

organic cyclic compound biosynthetic process [inference]

steroid biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

steroid hormone biosynthetic process [inference]

estrogen biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound metabolic process [inference]

alcohol metabolic process [inference]

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

secondary alcohol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

sterol metabolic process [inference]

cholesterol metabolic process [inference]

cholesterol biosynthetic process

sterol biosynthetic process [inference]

cholesterol biosynthetic process

organic hydroxy compound biosynthetic process [inference]

sterol biosynthetic process [inference]

cholesterol biosynthetic process

alcohol biosynthetic process [inference]

secondary alcohol biosynthetic process [inference]

cholesterol biosynthetic process

biological regulation [inference]

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

androgen metabolic process

estrogen metabolic process [inference]

estrogen biosynthetic process

hormone biosynthetic process [inference]

estrogen biosynthetic process

Displaying 1 entry
GO Term	Evidence Code	PMID
endoplasmic reticulum membrane	IBA IDA TAS	12829805

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
estradiol 17-beta-dehydrogenase [NAD(P)] activity	IBA IDA	12732193 19772289
5alpha-androstane-3beta,17beta-diol dehydrogenase activity	IBA IDA	12732193 19772289
3-keto sterol reductase activity	IBA IDA TAS	12829805

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

steroid dehydrogenase activity [inference]

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

oxidoreductase activity, acting on CH-OH group of donors [inference]

oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

3-keto sterol reductase activity

steroid dehydrogenase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor [inference]

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000132196

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K13373

Name

17beta-estradiol 17-dehydrogenase / 3beta-hydroxysteroid 3-dehydrogenase [EC:1.1.1.62 1.1.1.270]

References

12829805

Rhea

RHEA:24616

17β-estradiol + NADP⁺

H⁺ + estrone + NADPH

Enzyme

1.1.1.62

PMID

RHEA:18409

4α-methyl-5α-cholest-7-en-3β-ol + NADP⁺

H⁺ + 4α-methyl-5α-cholest-7-en-3-one + NADPH

Enzyme

1.1.1.270

PMID

RHEA:24612

17β-estradiol + NAD⁺

H⁺ + estrone + NADH

Enzyme

1.1.1.62

PMID

RHEA:16297

5α-androstane-3β,17β-diol + NADP⁺

H⁺ + 17β-hydroxy-5α-androstan-3-one + NADPH

Enzyme

1.1.1.210

PMID

RHEA:34787

a 3β-hydroxysteroid + NADP⁺

H⁺ + a 3-oxosteroid + NADPH

Enzyme

1.1.1.270

PMID

RHEA:36379

3-dehydro-4α-methylzymosterol + H⁺ + NADPH

4α-methylzymosterol + NADP⁺

Enzyme

1.1.1.270

PMID

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:0050771	pheochromocytoma	DisGeNET
DOID:0060891	Parkinson's disease 19A	DisGeNET
DOID:0060895	Parkinson's disease 4	DisGeNET
DOID:0060896	Parkinson's disease 23	DisGeNET
DOID:0080199	colorectal carcinoma	DisGeNET
DOID:0080348	Alzheimer's disease 1	DisGeNET
DOID:0080365	endometrial hyperplasia	DisGeNET
DOID:0080476	peroxisome biogenesis disorder 1A	DisGeNET
DOID:0090091	hypogonadotropic hypogonadism 23 with or without anosmia	DisGeNET
DOID:0110035	Alzheimer's disease 2	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001984
Gene Name: hydroxysteroid (17-beta) dehydrogenase 7

Ortholog

Displaying entries **1 - 10** of 73 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Callorhinchus milii	103180036		CALMI19483
Latimeria chalumnae	102348492		LATCH14448
Danio rerio	768185	ZFIN:ZDB-GENE-061013-378	DANRE37893
Astyanax mexicanus	103035681		ASTMX11559
Ictalurus punctatus	108271889		ICTPU02255
Electrophorus electricus	113570462		ELEEL08484
Salmo trutta	115156632		SALTR63528
Gadus morhua	115555654		GADMO06419
Sparus aurata	115572013		SPAAU36165
Sparus aurata	115591229		SPAAU68852

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements