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RNA 2',3'-cyclic phosphate and 5'-OH ligase

Summary

Gene Symbol

RTCB

Organism

Homo sapiens (human)

External Links

NCBI Gene

51493

PubChem

51493

Alliance of Genome Resources

HGNC:26935

JoGo

RTCB

TogoVar

RTCB

Annotation

Keyword

3D-structure
Cytoplasm
Direct protein sequencing
GTP-binding
Isopeptide bond
Ligase
Manganese
Metal-binding
Nucleus
Phosphoprotein
Proteomics identification
Reference proteome
Ubl conjugation
tRNA processing

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9Y3I0	3'-phosphate/5'-hydroxy nucleic acid ligase RNA 2',3'-cyclic phosphate and 5'-OH ligase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
in utero embryonic development	IEA
placenta development	IEA
tRNA splicing, via endonucleolytic cleavage and ligation	NAS	24870230
tRNA splicing, via endonucleolytic cleavage and ligation	IDA	21311021 24870230
tRNA splicing, via endonucleolytic cleavage and ligation	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA splicing [inference]

RNA splicing, via endonucleolytic cleavage and ligation [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA splicing [inference]

RNA splicing, via endonucleolytic cleavage and ligation [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA splicing [inference]

RNA splicing, via endonucleolytic cleavage and ligation [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA splicing [inference]

RNA splicing, via endonucleolytic cleavage and ligation [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA splicing [inference]

RNA splicing, via endonucleolytic cleavage and ligation [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA splicing [inference]

RNA splicing, via endonucleolytic cleavage and ligation [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA splicing [inference]

RNA splicing, via endonucleolytic cleavage and ligation [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA splicing [inference]

RNA splicing, via endonucleolytic cleavage and ligation [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA splicing [inference]

RNA splicing, via endonucleolytic cleavage and ligation [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA processing [inference]

RNA splicing [inference]

RNA splicing, via endonucleolytic cleavage and ligation [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA metabolic process [inference]

tRNA metabolic process [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

ncRNA processing [inference]

tRNA processing [inference]

tRNA splicing, via endonucleolytic cleavage and ligation

multicellular organismal process [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

developmental process [inference]

anatomical structure development [inference]

multicellular organism development [inference]

embryo development [inference]

embryo development ending in birth or egg hatching [inference]

chordate embryonic development [inference]

in utero embryonic development

animal organ development [inference]

placenta development

Displaying entries **1 - 5** of 14 in total

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2

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GO Term	Evidence Code	PMID
nucleus	NAS	21311021
nucleus	IDA	24608264
nucleus	IBA
nuclear envelope	IEA
nucleoplasm	TAS

GO Hierarchy

cellular component

protein-containing complex [inference]

intracellular protein-containing complex [inference]

tRNA-splicing ligase complex

catalytic complex [inference]

tRNA-splicing ligase complex

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

envelope [inference]

organelle envelope [inference]

nuclear envelope

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle

nucleus

Displaying entries **1 - 5** of 6 in total

1

2

Next ›

Last »
GO Term	Evidence Code	PMID
RNA binding	HDA	22658674 22681889
RNA ligase (ATP) activity
protein binding	IPI	24608264 24870230 25814554 30833792 35271311
GTP binding	IEA
vinculin binding	IPI	15163412

GO Hierarchy

molecular function

catalytic activity [inference]

ligase activity [inference]

ligase activity, forming phosphoric ester bonds [inference]

RNA ligase activity [inference]

RNA ligase (ATP) activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

RNA ligase activity [inference]

RNA ligase (ATP) activity

binding [inference]

protein binding

cytoskeletal protein binding [inference]

vinculin binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

GTP binding

cation binding [inference]

metal ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

RNA binding

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

guanyl nucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

purine ribonucleoside triphosphate binding [inference]

GTP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

guanyl ribonucleotide binding [inference]

GTP binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

splicing ligase RtcB

Functional Category

J: Translation, ribosomal structure and biogenesis
K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 9** entries
Gene Ontology
GTP binding
RNA ligase (ATP) activity
RNA ligase activity
ligase activity
metal ion binding
nucleotide binding
tRNA exon ligation utilizing 2',3' cyclic phosphate of 5'-exon as source of linkage phosphate
tRNA processing
tRNA splicing, via endonucleolytic cleavage and ligation