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NCK interacting protein with SH3 domain

Summary

Gene Symbol

NCKIPSD

Organism

Homo sapiens (human)

External Links

NCBI Gene

51517

PubChem

51517

Alliance of Genome Resources

HGNC:15486

Annotation

Keyword

3D-structure
Alternative splicing
Chromosomal rearrangement
Nucleus
Phosphoprotein
Proto-oncogene
Reference proteome
SH3 domain
SH3-binding

Proteins

Displaying 1 entry
UniProt	Protein Name
Q9NZQ3	54 kDa VacA-interacting protein 54 kDa vimentin-interacting protein 90 kDa SH3 protein interacting with Nck AF3p21 Dia-interacting protein 1 Diaphanous protein-interacting protein SH3 adapter protein SPIN90 WASP-interacting SH3-domain protein Wiskott-Aldrich syndrome protein-interacting protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endocytosis	IBA
cytoskeleton organization	NAS	10619843
positive regulation of neuron projection development	IEA
regulation of postsynapse assembly	IEA

GO Hierarchy

biological process

cellular process [inference]

vesicle-mediated transport [inference]

endocytosis

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

cytoskeleton organization

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endocytosis

import into cell [inference]

endocytosis

biological regulation [inference]

regulation of biological process [inference]

positive regulation of biological process [inference]

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of cellular process [inference]

regulation of cellular component biogenesis [inference]

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

positive regulation of cellular process [inference]

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of cellular component organization [inference]

regulation of cell projection organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of plasma membrane bounded cell projection organization [inference]

regulation of neuron projection development [inference]

positive regulation of neuron projection development

regulation of synapse organization [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

regulation of postsynapse organization [inference]

regulation of postsynapse assembly

positive regulation of cellular component organization [inference]

positive regulation of cell projection organization [inference]

positive regulation of neuron projection development

regulation of cell junction assembly [inference]

regulation of synapse assembly [inference]

regulation of postsynapse assembly

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
nucleus
nucleoplasm	IDA
cytosol	TAS
intermediate filament	NAS	10619843
plasma membrane	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

COP9 signalosome

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

cell junction [inference]

synapse [inference]

glutamatergic synapse

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

postsynapse

supramolecular complex [inference]

supramolecular polymer [inference]

supramolecular fiber [inference]

polymeric cytoskeletal fiber [inference]

intermediate filament

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	15095401 16189514 16999739 17474147 17537434 19460367 25416956 31515488 32296183 33961781
cytoskeletal protein binding	NAS	10619843
SH3 domain binding	IEA
Arp2/3 complex binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

cytoskeletal protein binding

protein domain specific binding [inference]

SH3 domain binding

protein-containing complex binding [inference]

Arp2/3 complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

NCK-interacting protein

Functional Category

G: Carbohydrate transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
Arp2/3 complex binding
actin cortical patch assembly
actin cortical patch localization

Displaying **all 4** entries
InterPro
SH3 domain
SH3-like domain superfamily
SPIN90/Ldb17, leucine-rich domain
SPIN90/Ldb17

Ortholog

Displaying entries **1 - 10** of 87 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	51517	Xenbase:XB-GENE-1010951
Mus musculus	80987	Xenbase:XB-GENE-1010951	MOUSE64413
Rattus norvegicus	301009		RATNO40981
Pan troglodytes	460351		PANTR31077
Bos taurus	516941		BOVIN17870
Macaca mulatta	709410		MACMU29385
Monodelphis domestica	100027173		MONDO29114
Ornithorhynchus anatinus	100074245		ORNAN29360
Equus caballus	100146927		HORSE12148
Callithrix jacchus	100414820		CALJA12627