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hyaluronidase 1

Summary

Gene Symbol

HYAL1

Organism

Bos taurus (cattle)

External Links

NCBI Gene: 515397
KEGG Gene ID: bta:515397
PubChem: 515397

Annotation

Keyword

Disulfide bond
EGF-like domain
Glycoprotein
Glycosidase
Lysosome
Reference proteome
Secreted
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
Q5E985	Hyaluronoglucosaminidase-1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **16 - 20** of 22 in total

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GO Term	Evidence Code	PMID
cellular response to platelet-derived growth factor stimulus
hyaluronan biosynthetic process
response to antibiotic
cellular response to UV-B
positive regulation of epithelial cell proliferation

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

mucopolysaccharide metabolic process [inference]

hyaluronan metabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

catabolic process [inference]

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

primary metabolic process [inference]

carbohydrate metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process

macromolecule metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

mucopolysaccharide metabolic process [inference]

hyaluronan metabolic process

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

carbohydrate derivative metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

mucopolysaccharide metabolic process [inference]

hyaluronan metabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

organonitrogen compound metabolic process [inference]

aminoglycan metabolic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

glycosaminoglycan metabolic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

mucopolysaccharide metabolic process [inference]

hyaluronan metabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

organic substance catabolic process [inference]

macromolecule catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

carbohydrate derivative catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

organonitrogen compound catabolic process [inference]

aminoglycan catabolic process [inference]

glycosaminoglycan catabolic process [inference]

hyaluronan catabolic process

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

carbohydrate derivative biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

organonitrogen compound biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

aminoglycan biosynthetic process [inference]

glycosaminoglycan biosynthetic process [inference]

hyaluronan biosynthetic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-1

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to pH

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-B

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

cartilage development

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to virus

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

response to oxidative stress [inference]

response to reactive oxygen species

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to virus

response to abiotic stimulus [inference]

response to pH [inference]

cellular response to pH

response to radiation [inference]

response to light stimulus [inference]

response to UV [inference]

response to UV-B [inference]

cellular response to UV-B

cellular response to UV [inference]

cellular response to UV-B

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-B

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-B

cellular response to abiotic stimulus [inference]

cellular response to pH

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-B

response to endogenous stimulus [inference]

response to growth factor [inference]

response to platelet-derived growth factor [inference]

cellular response to platelet-derived growth factor stimulus

cellular response to growth factor stimulus [inference]

cellular response to platelet-derived growth factor stimulus

cellular response to endogenous stimulus [inference]

cellular response to growth factor stimulus [inference]

cellular response to platelet-derived growth factor stimulus

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

response to interleukin-1 [inference]

cellular response to interleukin-1

cellular response to cytokine stimulus [inference]

cellular response to interleukin-1

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-1

response to antibiotic

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-1

response to oxygen-containing compound [inference]

response to reactive oxygen species

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to interleukin-1

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to pH

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-B

biological regulation [inference]

regulation of biological process [inference]

regulation of growth [inference]

regulation of cell growth [inference]

negative regulation of growth [inference]

negative regulation of cell growth

positive regulation of growth

positive regulation of cell growth

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

positive regulation of epithelial cell migration

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration

positive regulation of biological process [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration

positive regulation of growth

positive regulation of cell growth

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation

positive regulation of cell growth

positive regulation of cellular component biogenesis [inference]

positive regulation of hyaluranon cable assembly

positive regulation of cell adhesion

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cellular component organization [inference]

positive regulation of hyaluranon cable assembly

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

negative regulation of biological process [inference]

negative regulation of growth [inference]

negative regulation of cell growth

negative regulation of cellular process [inference]

negative regulation of cell growth

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of developmental process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of cellular process [inference]

regulation of cell adhesion [inference]

positive regulation of cell adhesion

regulation of cell population proliferation [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation

regulation of epithelial cell proliferation [inference]

positive regulation of epithelial cell proliferation

regulation of cellular component biogenesis [inference]

positive regulation of cellular component biogenesis [inference]

positive regulation of hyaluranon cable assembly

regulation of hyaluranon cable assembly [inference]

positive regulation of hyaluranon cable assembly

positive regulation of cellular process [inference]

positive regulation of cell population proliferation [inference]

positive regulation of epithelial cell proliferation

positive regulation of cell growth

positive regulation of cellular component biogenesis [inference]

positive regulation of hyaluranon cable assembly

positive regulation of cell adhesion

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cellular component organization [inference]

positive regulation of hyaluranon cable assembly

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration

negative regulation of cellular process [inference]

negative regulation of cell growth

regulation of cellular component organization [inference]

regulation of cell growth [inference]

positive regulation of cellular component organization [inference]

positive regulation of hyaluranon cable assembly

regulation of hyaluranon cable assembly [inference]

positive regulation of hyaluranon cable assembly

regulation of cell cycle [inference]

regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle process [inference]

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle phase transition [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of mitotic cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of cell cycle G1/S phase transition [inference]

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of G1/S transition of mitotic cell cycle [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle [inference]

positive regulation of mitotic cell cycle [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle process [inference]

positive regulation of cell cycle phase transition [inference]

positive regulation of mitotic cell cycle phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

positive regulation of cell cycle G1/S phase transition [inference]

positive regulation of G1/S transition of mitotic cell cycle

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

positive regulation of epithelial cell migration

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration

regulation of multicellular organismal process [inference]

regulation of epithelial cell migration [inference]

positive regulation of epithelial cell migration

positive regulation of multicellular organismal process [inference]

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis [inference]

positive regulation of angiogenesis

positive regulation of vasculature development [inference]

positive regulation of angiogenesis

Displaying **all 5** entries
GO Term	Evidence Code	PMID
cytoplasm
hyaluranon cable
extracellular space
lysosome
cytoplasmic vesicle

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular vesicle [inference]

cytoplasmic vesicle

Displaying **all 2** entries
GO Term	Evidence Code	PMID
hyaluronan synthase activity
hyalurononglucosaminidase activity	IEA	22301074 30032202

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity [inference]

hyaluronan synthase activity

hexosyltransferase activity [inference]

hyaluronan synthase activity

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing O-glycosyl compounds [inference]

hexosaminidase activity [inference]

hyalurononglucosaminidase activity

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K01197

Name

hyaluronoglucosaminidase [EC:3.2.1.35]

References

Reactions

Displaying **all 3** entries
KEGG Reaction	Enzyme	Acceptor	Product
R07825	3.2.1.35	G34586BV	G92988PL
R07824	3.2.1.35	G81393WR	G92988PL
R10905	3.2.1.35	G16235VG	G16235VG G93263XO

Ortholog

Displaying entries **51 - 60** of 74 in total

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Species	Gene ID	Orthologous MAtrix
Ictidomys tridecemlineatus	101975781	ICTTR14825
Jaculus jaculus	101600161	JACJA15697
Scophthalmus maximus	118309900	SCOMX27327
Myotis lucifugus	102423475	MYOLU18786
Rhinolophus ferrumequinum	117036739	RHIFE16807
Taeniopygia guttata	100219184	TAEGU03332
Ficedula albicollis	101820552	FICAL07726
Chlorocebus sabaeus	103227668	CHLSB10381
Rhinopithecus bieti	108526956	RHIBE18842
Rhinopithecus roxellana	104667013	RHIRO13913

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Acknowledgements