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complement C2

Summary

Gene Symbol

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 515440
PubChem: 515440

Annotation

Keyword

Complement pathway
Disulfide bond
Glycoprotein
Metal-binding
Reference proteome
Repeat
Secreted
Serine protease
Signal
Sushi

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q0V7N2	C3/C5 convertase
Q3SYW2	C3/C5 convertase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
proteolysis	IEA	22301074
complement activation	IEA	22301074 30032202
complement activation, classical pathway
response to bacterium	IEA	30032202
innate immune response

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation

complement activation, classical pathway

activation of immune response [inference]

complement activation

complement activation, classical pathway

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, classical pathway

innate immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

proteolysis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response

immune response [inference]

humoral immune response [inference]

complement activation

complement activation, classical pathway

innate immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

innate immune response

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation

complement activation, classical pathway

Displaying **all 3** entries
GO Term	Evidence Code	PMID
extracellular region	IEA	22301074 30032202
classical-complement-pathway C3/C5 convertase complex	IEA	30032202
extracellular exosome	IEA	30032202

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

classical-complement-pathway C3/C5 convertase complex

cellular anatomical entity [inference]

extracellular region

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 2** entries
GO Term	Evidence Code	PMID
serine-type endopeptidase activity	IEA	22301074 30032202
metal ion binding

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity [inference]

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

complement factor B

Functional Category

E: Amino acid transport and metabolism
G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
complement activation
proteolysis
serine-type endopeptidase activity

Displaying **all 9** entries
InterPro
Complement B/C2
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin domain
Serine proteases, trypsin family, histidine active site
Sushi/SCR/CCP domain
von Willebrand factor A-like domain superfamily
von Willebrand factor, type A

Ortholog

Displaying entries **1 - 10** of 50 in total

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Species	Gene ID	Orthologous MAtrix
Homo sapiens	717	HUMAN84084
Mus musculus	12263	MOUSE20465
Rattus norvegicus	24231	RATNO22658
Rattus norvegicus	294257	RATNO22658
Canis lupus familiaris	474853	CANLF02575
Pan troglodytes	494140	PANTR37756
Ciona intestinalis	497244	CIOIN03737
Macaca mulatta	716809	MACMU35126
Monodelphis domestica	100025443	MONDO12087
Pongo abelii	100173033	PONAB30661