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lysine demethylase 3B

Summary

Gene Symbol

KDM3B

Organism

Homo sapiens (human)

External Links

NCBI Gene

51780

PubChem

51780

Alliance of Genome Resources

HGNC:1337

Annotation

Keyword

3D-structure
Acetylation
Alternative splicing
Chromatin regulator
Dioxygenase
Disease variant
Dwarfism
Intellectual disability
Iron
Isopeptide bond
Nucleus
Phosphoprotein
Reference proteome
Transcription regulation
Ubl conjugation
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q7LBC6	JmjC domain-containing histone demethylation protein 2B Jumonji domain-containing protein 1B Nuclear protein 5qNCA [histone H3]-dimethyl-L-lysine(9) demethylase 3B

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
chromatin remodeling	IEA
regulation of transcription by RNA polymerase II	IBA
cellular oxidant detoxification	IEA

GO Hierarchy

biological process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling

cellular detoxification [inference]

cellular oxidant detoxification

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of RNA metabolic process [inference]

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

regulation of RNA biosynthetic process [inference]

regulation of DNA-templated transcription [inference]

regulation of transcription by RNA polymerase II

detoxification [inference]

cellular detoxification [inference]

cellular oxidant detoxification

Displaying **all 4** entries
GO Term	Evidence Code	PMID
histone deacetylase complex	IBA
chromatin	IBA
nucleoplasm	TAS
nucleoplasm	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

protein-DNA complex [inference]

chromatin

nuclear protein-containing complex [inference]

histone deacetylase complex

catalytic complex [inference]

histone deacetylase complex

cellular anatomical entity [inference]

nucleoplasm

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
transcription coregulator activity	IBA
zinc ion binding	IEA
antioxidant activity	IEA
chromatin DNA binding	IBA
histone H3K9 demethylase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

histone H3K9me/H3K9me2 demethylase activity

FAD-dependent histone H3K9me/H3K9me2 demethylase activity

dioxygenase activity [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

histone H3K9me/H3K9me2 demethylase activity

demethylase activity [inference]

protein demethylase activity [inference]

histone demethylase activity [inference]

histone H3 demethylase activity [inference]

histone H3K9 demethylase activity

catalytic activity, acting on a protein [inference]

protein demethylase activity [inference]

histone demethylase activity [inference]

histone H3 demethylase activity [inference]

histone H3K9 demethylase activity

histone modifying activity [inference]

histone demethylase activity [inference]

histone H3 demethylase activity [inference]

histone H3K9 demethylase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding [inference]

chromatin binding [inference]

chromatin DNA binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

chromatin DNA binding

antioxidant activity

transcription regulator activity [inference]

transcription coregulator activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

lysine-specific demethylase

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
chromatin DNA binding
histone H3K9 demethylase activity

Displaying **all 2** entries
InterPro
Histone demethylase JHDM2-like
JmjC domain

Ortholog

Displaying entries **1 - 10** of 96 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	11941	Xenbase:XB-GENE-960658
Xenopus tropicalis	51780	Xenbase:XB-GENE-960658
Drosophila melanogaster	55818	FB:FBgn0037703
Drosophila melanogaster	104263	FB:FBgn0037703
Drosophila melanogaster	108829	FB:FBgn0037703
Xenopus tropicalis	177795	Xenbase:XB-GENE-960658
Drosophila melanogaster	221037	FB:FBgn0037703
Mus musculus	277250	Xenbase:XB-GENE-960658	MOUSE23615
Danio rerio	326643		DANRE07706
Pan troglodytes	462095		PANTR36266

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