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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
acyl-CoA oxidase 1
Summary
- Gene Symbol
-
- ACOX1
- Aliases
-
- PALMCOX
- palmitoyl-CoA oxidase
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Acetylation
- Alternative splicing
- Deafness
- Disease variant
- FAD
- Fatty acid metabolism
- Neuropathy
- Oxidoreductase
- Peroxisome
- Phosphoprotein
- Reference proteome
- Proteins
| UniProt | Protein Name |
|---|---|
| Q15067 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| hydrogen peroxide biosynthetic process | ||
| fatty acid beta-oxidation using acyl-CoA oxidase | ||
| spermatogenesis | ||
| fatty acid catabolic process | ||
| lipid metabolic process |
GO Hierarchy
biological process
metabolic process [inference]
catabolic process [inference]
cellular metabolic process [inference]
primary metabolic process [inference]
small molecule metabolic process [inference]
organic substance metabolic process [inference]
cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytosol |
|
|
| membrane | ||
| peroxisome | ||
| peroxisomal membrane | ||
| peroxisomal matrix |
|
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| flavin adenine dinucleotide binding | ||
| protein homodimerization activity | ||
| fatty acid binding | ||
| acyl-CoA oxidase activity | ||
| PDZ domain binding |
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0014667 | disease of metabolism | |
| DOID:0050564 | autosomal dominant nonsyndromic deafness | |
| DOID:0050565 | autosomal recessive nonsyndromic deafness | |
| DOID:0050566 | X-linked nonsyndromic deafness | |
| DOID:0050572 | cone-rod dystrophy | |
| DOID:0050591 | tooth agenesis | |
| DOID:0050797 | peroxisomal acyl-CoA oxidase deficiency | |
| DOID:0060058 | lymphoma | |
| DOID:0060690 | autosomal dominant auditory neuropathy 1 | |
| DOID:0060823 | syndromic X-linked intellectual disability 94 |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0003593 | Infantile onset |
| HP:0003623 | Neonatal onset |
| HP:0003690 | Limb muscle weakness |
| HP:0005280 | Depressed nasal bridge |
| HP:0006555 | Diffuse hepatic steatosis |
| HP:0006887 | Intellectual disability, progressive |
| HP:0007305 | CNS demyelination |
| HP:0008167 | Very long chain fatty acid accumulation |
| HP:0008619 | Bilateral sensorineural hearing impairment |
| HP:0008763 | No social interaction |
| Disease ID | Disease Name |
|---|---|
| ORPHA:2971 |
|
| OMIM:264470 |
|
| OMIM:618960 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP002411
- Gene Name
- acyl-CoA oxidase 1, palmitoyl
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 100135467 | CAVPO24639 | ||
| 101564686 | OCTDE08010 | ||
| 101705097 | HETGA13724 | ||
| 102463291 | PELSI11726 | ||
| 100562736 | ANOCA03050 | ||
| 103665753 | URSMA11004 | ||
| 114050814 | VOMUR12490 | ||
| 113877957 | BOBOX14597 | ||
| 102536864 | VICPA09943 | ||
| 100943743 | OTOGA14765 |
