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MIRAGE
profilin 1
Summary
- Gene Symbol
-
- PFN1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Actin-binding
- Amyotrophic lateral sclerosis
- Cytoskeleton
- Direct protein sequencing
- Disease variant
- Isopeptide bond
- Phosphoprotein
- Reference proteome
- Ubl conjugation
- Proteins
| UniProt | Protein Name |
|---|---|
| P07737 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| neural tube closure | ||
| regulation of transcription by RNA polymerase II | ||
| positive regulation of epithelial cell migration | ||
| actin cytoskeleton organization | ||
| regulation of actin filament polymerization |
GO Hierarchy
biological process
biological regulation [inference]
regulation of biological process [inference]
regulation of metabolic process [inference]
positive regulation of biological process [inference]
regulation of cellular process [inference]
regulation of actin filament-based process [inference]
regulation of cellular component biogenesis [inference]
positive regulation of cellular process [inference]
regulation of cellular component organization [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| adenyl-nucleotide exchange factor activity | ||
| phosphotyrosine residue binding | ||
| RNA binding | ||
| actin binding | ||
| actin binding |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- profilin
- Functional Category
-
- E: Amino acid transport and metabolism
- O: Posttranslational modification, protein turnover, chaperones
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| actin binding |
| actin monomer binding |
| sequestering of actin monomers |
| InterPro |
|---|
| Profilin conserved site |
| Profilin superfamily |
| Profilin, eukaryotic type |
| Profilin |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060209 | amyotrophic lateral sclerosis type 18 |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 105714253 | AOTNA26801 | ||
| 105722834 | AOTNA26801 | ||
| 105983505 | DIPOR08673 | ||
| 110194471 | PHACI22235 | ||
| 113877777 | BOBOX14133 | ||
| 114039403 | VOMUR26976 | ||
| 114808039 | ORNAN31540 | ||
| 116438748 | CORMO00240 | ||
| 117013937 | RHIFE08002 | ||
| 118886715 | BALMU11367 |
