GlyCosmos Portal

Displaying entries **1 - 5** of 18 in total

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GO Term	Evidence Code	PMID
extrinsic component of synaptic vesicle membrane	IEA
intracellular membrane-bounded organelle	IDA
cytosol	IDA ISS TAS
clathrin-coated vesicle membrane	IEA
secretory granule	IDA	23035048

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

proton-transporting two-sector ATPase complex

proton-transporting V-type ATPase complex

proton-transporting two-sector ATPase complex, catalytic domain [inference]

proton-transporting V-type ATPase, V1 domain [inference]

vacuolar proton-transporting V-type ATPase, V1 domain

transmembrane transporter complex

catalytic complex [inference]

ATPase complex [inference]

proton-transporting two-sector ATPase complex

proton-transporting V-type ATPase complex

transporter complex [inference]

transmembrane transporter complex

cellular anatomical entity [inference]

membrane

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane

bounding membrane of organelle [inference]

Golgi membrane

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

endosome membrane

coated vesicle membrane [inference]

clathrin-coated vesicle membrane

plasma membrane region [inference]

apical plasma membrane

extrinsic component of membrane [inference]

extrinsic component of organelle membrane [inference]

extrinsic component of synaptic vesicle membrane

cell projection [inference]

plasma membrane bounded cell projection [inference]

actin-based cell projection [inference]

microvillus

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
proton-transporting ATPase activity, rotational mechanism	IBA
proton-transporting ATP synthase activity, rotational mechanism	IEA
ATP binding	IEA
protein binding	IPI	23035048 33208464
ATP hydrolysis activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on acid anhydrides [inference]

hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides [inference]

pyrophosphatase activity [inference]

ribonucleoside triphosphate phosphatase activity [inference]

ATP hydrolysis activity

ligase activity [inference]

proton-transporting ATP synthase activity, rotational mechanism

transporter activity [inference]

transmembrane transporter activity [inference]

monoatomic ion transmembrane transporter activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

proton channel activity [inference]

proton-transporting ATP synthase activity, rotational mechanism

monoatomic cation transmembrane transporter activity [inference]

monoatomic cation channel activity [inference]

proton channel activity [inference]

proton-transporting ATP synthase activity, rotational mechanism

proton transmembrane transporter activity [inference]

proton channel activity [inference]

proton-transporting ATP synthase activity, rotational mechanism

proton-transporting ATPase activity, rotational mechanism

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

inorganic molecular entity transmembrane transporter activity [inference]

inorganic cation transmembrane transporter activity [inference]

proton transmembrane transporter activity [inference]

proton channel activity [inference]

proton-transporting ATP synthase activity, rotational mechanism

proton-transporting ATPase activity, rotational mechanism

passive transmembrane transporter activity [inference]

channel activity [inference]

monoatomic ion channel activity [inference]

monoatomic cation channel activity [inference]

proton channel activity [inference]

proton-transporting ATP synthase activity, rotational mechanism

active transmembrane transporter activity [inference]

primary active transmembrane transporter activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

ATPase-coupled ion transmembrane transporter activity [inference]

ATPase activity, coupled to transmembrane movement of ions, rotational mechanism [inference]

proton-transporting ATPase activity, rotational mechanism

active monoatomic ion transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ATP-dependent activity [inference]

ATPase-coupled transmembrane transporter activity [inference]

ATPase-coupled monoatomic cation transmembrane transporter activity [inference]

proton-transporting ATPase activity, rotational mechanism

ATPase-coupled ion transmembrane transporter activity [inference]

ATPase activity, coupled to transmembrane movement of ions, rotational mechanism [inference]

proton-transporting ATPase activity, rotational mechanism

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000114573

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K02145

Name

V-type H+-transporting ATPase subunit A [EC:7.1.2.2]

References

Rhea

RHEA:57720

H₂O + H⁺ + ATP

H⁺ + phosphate + ADP

Enzyme

7.1.2.2

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of **111** in total

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DO ID	Disease Name	Source
DOID:4090	agnosia	DisGeNET
DOID:0050133	superficial mycosis	DisGeNET
DOID:0050453	lissencephaly	DisGeNET
DOID:0050591	tooth agenesis	DisGeNET
DOID:0050700	cardiomyopathy	DisGeNET
DOID:0050777	Joubert syndrome	DisGeNET
DOID:0050841	focal hand dystonia	DisGeNET
DOID:0060260	ptosis	DisGeNET
DOID:0060261	congenital ptosis	DisGeNET
DOID:0060270	pontocerebellar hypoplasia type 2D	DisGeNET

The Human Phenotype Ontology

Displaying entries **91 - 100** of **143** in total

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HPO ID	HPO Term
HP:0002317	Unsteady gait
HP:0002355	Difficulty walking
HP:0002361	Psychomotor deterioration
HP:0002373	Febrile seizure (within the age range of 3 months to 6 years)
HP:0002376	Developmental regression
HP:0002421	Poor head control
HP:0002465	Poor speech
HP:0002509	Limb hypertonia
HP:0002521	Hypsarrhythmia
HP:0002540	Inability to walk

Displaying **all 4** entries
Disease ID	Disease Name
OMIM:618012	epileptic encephalopathy, infantile or early childhood, 3
ORPHA:357074	autosomal recessive cutis laxa type 2, classic type
ORPHA:442835	developmental and epileptic encephalopathy, 58 developmental delay and seizures with or without movement abnormalities intellectual disability, X-linked, syndromic, Houge type intellectual disability, autosomal dominant 55, with seizures intellectual disability, autosomal dominant 56 undetermined early-onset epileptic encephalopathy
OMIM:617403	autosomal recessive cutis laxa type 2D

PubChem Disease

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **121 - 130** of **142** in total

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Species	Gene ID	Orthologous MAtrix
Amphiprion ocellaris	111587180	AMPOC11867
Equus asinus asinus	106829494	EQUAS04610
Chelonoidis abingdonii	116820873	CHEAB09521
Hippocampus comes	109514041	HIPCM25504
Hippocampus comes	109517920	HIPCM09392
Pteropus vampyrus	105303967	PTEVA08722
Echeneis naucrates	115053936	ECHNA44440
Echeneis naucrates	115060841	ECHNA37890
Salarias fasciatus	115394326	SALFA02706
Salarias fasciatus	115395456	SALFA26121

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

International Collaboration

Acknowledgements