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MIRAGE
ATP binding cassette subfamily B member 4
Summary
- Gene Symbol
-
- ABCB4
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- ATP-binding
- Alternative splicing
- Cell membrane
- Cytoplasm
- Cytoplasmic vesicle
- Disease variant
- Glycoprotein
- Intrahepatic cholestasis
- Lipid transport
- Phosphoprotein
- Reference proteome
- Repeat
- Translocase
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| P21439 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| lipid metabolic process | ||
| positive regulation of cholesterol transport | ||
| positive regulation of cholesterol transport | ||
| bile acid secretion | ||
| phospholipid translocation |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| nucleoplasm | ||
| cytoplasm | ||
| cytosol | ||
| plasma membrane | ||
| plasma membrane |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| ATP binding | ||
| phospholipid transporter activity | ||
| ATP hydrolysis activity | ||
| ATPase-coupled transmembrane transporter activity |
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- ABC
- Functional Category
-
- J: Translation, ribosomal structure and biogenesis
- K: Transcription
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| ABC-type transporter activity |
| ATP binding |
| nucleotide binding |
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0070223 | progressive familial intrahepatic cholestasis 3 | |
| DOID:0070229 | intrahepatic cholestasis of pregnancy 3 | |
| DOID:12236 | primary biliary cholangitis | |
| DOID:13580 | cholestasis | |
| DOID:1852 | intrahepatic cholestasis | |
| DOID:5082 | liver cirrhosis |
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 5243 | ZFIN:ZDB-GENE-080204-52 | ||
| 5244 | ZFIN:ZDB-GENE-080204-52 | ||
| 8647 | SGD:S000001692 | ||
| 18669 | ZFIN:ZDB-GENE-080204-52 | ||
| 18670 | ZFIN:ZDB-GENE-080204-52 | MOUSE44040 | |
| 18671 | ZFIN:ZDB-GENE-080204-52 | ||
| 24891 | ZFIN:ZDB-GENE-080204-52 | RATNO30604 | |
| 27413 | SGD:S000001692 | ||
| 36428 | ZFIN:ZDB-GENE-080204-52 | ||
| 38726 | ZFIN:ZDB-GENE-080204-52 |
