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MIRAGE

PHD finger protein 1

Summary

Gene Symbol

PHF1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5252

PubChem

5252

Alliance of Genome Resources

HGNC:8919

Annotation

Keyword

3D-structure
Alternative splicing
Chromatin regulator
Chromosomal rearrangement
Cytoskeleton
DNA damage
Nucleus
Phosphoprotein
Reference proteome
Repeat
Repressor
Transcription regulation
Zinc-finger

Proteins

Displaying **all 3** entries
UniProt	Protein Name
O43189	Polycomb-like protein 1
A0A140VJR4
A0A1U9X8A3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 2** entries
GO Term	Evidence Code	PMID
DNA repair-dependent chromatin remodeling	IDA	23142980
negative regulation of gene expression, epigenetic	IBA

GO Hierarchy

biological process

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

protein-containing complex organization [inference]

protein-DNA complex organization [inference]

chromatin organization [inference]

chromatin remodeling [inference]

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

DNA repair-dependent chromatin remodeling

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

epigenetic regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of gene expression, epigenetic

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
nucleus	IBA IDA	23273982
ESC/E(Z) complex	IDA	23273982
centrosome	IDA	20873783
nucleoplasm	IDA TAS
cytosol	IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

PcG protein complex [inference]

ESC/E(Z) complex

histone methyltransferase complex [inference]

ESC/E(Z) complex

catalytic complex [inference]

transferase complex [inference]

methyltransferase complex [inference]

histone methyltransferase complex [inference]

ESC/E(Z) complex

cellular anatomical entity [inference]

nucleoplasm

microtubule organizing center [inference]

centrosome

cytosol

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

site of DNA damage [inference]

site of double-strand break

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
DNA binding	IBA
metal ion binding
zinc ion binding	IEA
methylated histone binding	IBA IDA	23142980 23273982
transcription corepressor binding	IPI	29628311

GO Hierarchy

molecular function

binding [inference]

protein binding

transcription factor binding [inference]

transcription coregulator binding [inference]

transcription corepressor binding

enzyme binding [inference]

histone methyltransferase binding

histone binding [inference]

methylated histone binding

identical protein binding

modification-dependent protein binding [inference]

methylation-dependent protein binding [inference]

methylated histone binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding [inference]

chromatin binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying entries **31 - 40** of 48 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Ursus maritimus	103665486		URSMA24567
Nannospalax galili	103739699		NANGA06901
Rhinopithecus roxellana	104657965		RHIRO41204
Pteropus vampyrus	105300993		PTEVA06569
Macaca nemestrina	105474460		MACNE35202
Mandrillus leucophaeus	105544173		MANLE00455
Cercocebus atys	105593346		CERAT04932
Aotus nancymaae	105723560		AOTNA30763
Propithecus coquereli	105821677		PROCO30351
Microcebus murinus	105885982		MICMU03990

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Last updated: February 17, 2025