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Guidelines

MIRAGE

phosphorylase kinase regulatory subunit alpha 1

Summary

Gene Symbol

PHKA1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5255

PubChem

5255

Alliance of Genome Resources

HGNC:8925

JoGo

PHKA1

TogoVar

PHKA1

Annotation

Keyword

3D-structure
Alternative splicing
Calmodulin-binding
Cell membrane
Disease variant
Glycogen metabolism
Glycogen storage disease
Muscle protein
Phosphoprotein
Prenylation
Proteomics identification
Reference proteome

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P46020
A6NMN0

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
glycogen metabolic process	IEA
generation of precursor metabolites and energy	TAS	7874115
positive regulation of glycogen catabolic process	IMP	33799212

GO Hierarchy

biological process

metabolic process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

primary metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

organic substance metabolic process [inference]

carbohydrate metabolic process [inference]

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of small molecule metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of catabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

regulation of carbohydrate catabolic process [inference]

regulation of glycogen catabolic process [inference]

positive regulation of glycogen catabolic process

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

regulation of generation of precursor metabolites and energy [inference]

regulation of glycogen metabolic process [inference]

regulation of glycogen catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of polysaccharide metabolic process [inference]

regulation of glycogen metabolic process [inference]

regulation of glycogen catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of small molecule metabolic process [inference]

regulation of glucose metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of small molecule metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of primary metabolic process [inference]

regulation of carbohydrate metabolic process [inference]

regulation of glucose metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of polysaccharide metabolic process [inference]

regulation of glycogen metabolic process [inference]

regulation of glycogen catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of carbohydrate catabolic process [inference]

regulation of glycogen catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of macromolecule metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of carbohydrate metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of small molecule metabolic process [inference]

positive regulation of glucose metabolic process [inference]

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

regulation of cellular catabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

regulation of generation of precursor metabolites and energy [inference]

regulation of glycogen metabolic process [inference]

regulation of glycogen catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of cellular process [inference]

positive regulation of cellular metabolic process [inference]

positive regulation of cellular catabolic process [inference]

positive regulation of glycogen catabolic process

positive regulation of glycogen metabolic process [inference]

positive regulation of glycogen catabolic process

Displaying **all 3** entries
GO Term	Evidence Code	PMID
cytosol	TAS
plasma membrane	IEA
phosphorylase kinase complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

protein kinase complex [inference]

serine/threonine protein kinase complex [inference]

phosphorylase kinase complex

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
phosphorylase kinase activity	TAS	8226841
protein binding	IPI	32296183
calmodulin binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

calmodulin-dependent protein kinase activity [inference]

phosphorylase kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

calmodulin-dependent protein kinase activity [inference]

phosphorylase kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

calmodulin-dependent protein kinase activity [inference]

phosphorylase kinase activity

binding [inference]

protein binding

calmodulin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Phosphorylase b kinase regulatory subunit

Functional Category

G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 2** entries
Gene Ontology
calmodulin binding
glycogen metabolic process

Displaying **all 5** entries
InterPro
GH15-like domain
Phosphorylase b kinase regulatory subunit alpha/beta, C-terminal domain
Phosphorylase kinase alpha/beta subunit
Six-hairpin glycosidase superfamily
Six-hairpin glycosidase-like superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111040	glycogen storage disease IXd	Alliance of Genome Resources
DOID:2747	glycogen storage disease	Alliance of Genome Resources

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025