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phosphorylase kinase regulatory subunit alpha 2

Summary

Gene Symbol

PHKA2

Organism

Homo sapiens (human)

External Links

NCBI Gene

5256

PubChem

5256

Alliance of Genome Resources

HGNC:8926

Annotation

Keyword

Calmodulin-binding
Cell membrane
Disease variant
Glycogen metabolism
Glycogen storage disease
Phosphoprotein
Prenylation
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
P46019

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
carbohydrate metabolic process	TAS	7549948
glycogen metabolic process	IEA
generation of precursor metabolites and energy	TAS	7549948
protein modification process	TAS	7549948

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process

cellular metabolic process [inference]

generation of precursor metabolites and energy

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

primary metabolic process [inference]

carbohydrate metabolic process

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

protein metabolic process [inference]

protein modification process

organic substance metabolic process [inference]

carbohydrate metabolic process

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

macromolecule metabolic process [inference]

polysaccharide metabolic process [inference]

glucan metabolic process [inference]

glycogen metabolic process

protein metabolic process [inference]

protein modification process

macromolecule modification [inference]

protein modification process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process

cellular process [inference]

cellular metabolic process [inference]

generation of precursor metabolites and energy

energy derivation by oxidation of organic compounds [inference]

energy reserve metabolic process [inference]

glycogen metabolic process

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytosol	TAS
plasma membrane	IEA
phosphorylase kinase complex	IBA
phosphorylase kinase complex	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

protein kinase complex [inference]

serine/threonine protein kinase complex [inference]

phosphorylase kinase complex

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
phosphorylase kinase activity	TAS	7549948
protein binding	IPI	23455922 26496610 28514442 32296183 32707033 32814053 33961781 35271311
calmodulin binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

calmodulin-dependent protein kinase activity [inference]

phosphorylase kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

calmodulin-dependent protein kinase activity [inference]

phosphorylase kinase activity

catalytic activity, acting on a protein [inference]

protein kinase activity [inference]

protein serine/threonine kinase activity [inference]

calmodulin-dependent protein kinase activity [inference]

phosphorylase kinase activity

binding [inference]

protein binding

calmodulin binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Phosphorylase b kinase regulatory subunit

Functional Category

G: Carbohydrate transport and metabolism
T: Signal transduction mechanisms
X: Mobilome: prophages, transposons

Displaying **all 2** entries
Gene Ontology
calmodulin binding
glycogen metabolic process

Displaying **all 5** entries
InterPro
GH15-like domain
Phosphorylase b kinase regulatory subunit alpha/beta, C-terminal domain
Phosphorylase kinase alpha/beta subunit
Six-hairpin glycosidase superfamily
Six-hairpin glycosidase-like superfamily

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0111042	glycogen storage disease IXa	Alliance of Genome Resources
DOID:2747	glycogen storage disease	Alliance of Genome Resources

Ortholog

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	5255	FB:FBgn0030087
Danio rerio	5256	ZFIN:ZDB-GENE-130422-1
Drosophila melanogaster	18679	FB:FBgn0030087
Danio rerio	31839	ZFIN:ZDB-GENE-130422-1
Mus musculus	110094	ZFIN:ZDB-GENE-130422-1	MOUSE65820
Danio rerio	176149	ZFIN:ZDB-GENE-130422-1
Pan troglodytes	465523		PANTR45588
Bos taurus	515732		BOVIN37390
Danio rerio	556199		DANRE02706
Rattus norvegicus	678739		RATNO45335

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OrthoDB (Group)

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Acknowledgements