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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
phosphatidylinositol glycan anchor biosynthesis class A
Summary
- Gene Symbol
-
- PIGA
- Aliases
-
- GPI3
- GPI3 (SPT14) homolog (S. cerevisiae)
- PIG-A
- Phosphatidylinositol N-acetylglucosaminyltransferase subunit A
- paroxysmal nocturnal hemoglobinuria
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Alternative splicing
- Disease variant
- Endoplasmic reticulum
- Epilepsy
- GPI-anchor biosynthesis
- Glycoprotein
- Glycosyltransferase
- Intellectual disability
- Lipid metabolism
- Phosphoprotein
- Reference proteome
- Transmembrane helix
- Proteins
| UniProt | Protein Name |
|---|---|
| P37287 |
|
| A0A2K4ZA02 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| GPI anchor biosynthetic process | ||
| preassembly of GPI anchor in ER membrane |
|
|
| cellular response to leukemia inhibitory factor |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| protein binding | ||
| phosphatidylinositol N-acetylglucosaminyltransferase activity | ||
| UDP-glycosyltransferase activity |
GO Hierarchy
OrthoDB (Group)
- Group level
- Eukaryota
- Group Name
- phosphatidylinositol
- Functional Category
-
- E: Amino acid transport and metabolism
- M: Cell wall/membrane/envelope biogenesis
- T: Signal transduction mechanisms
| Gene Ontology |
|---|
| phosphatidylinositol N-acetylglucosaminyltransferase activity |
| transferase activity |
| InterPro |
|---|
| Glycosyl transferase, family 1 |
| PIGA, GPI anchor biosynthesis |
| Phosphatidylinositol N-acetylglucosaminyltransferase subunit PIG-A/GPI3 |
GlycoGene Database (GGDB)
- GGDB ID
- gg215
- Gene Symbol
-
- PIGA
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0060284 | paroxysmal nocturnal hemoglobinuria | |
| DOID:0060713 | autosomal recessive congenital ichthyosis 4B | |
| DOID:0080139 | multiple congenital anomalies-hypotonia-seizures syndrome 2 |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000054 | Micropenis |
| HP:0000076 | Vesicoureteral reflux |
| HP:0000081 | Duplicated collecting system |
| HP:0000083 | Renal insufficiency |
| HP:0000093 | Proteinuria |
| HP:0000160 | Narrow mouth |
| HP:0000201 | Pierre-Robin sequence |
| HP:0000207 | Triangular mouth |
| HP:0000212 | Gingival overgrowth |
| HP:0000218 | High palate |
| Disease ID | Disease Name |
|---|---|
| ORPHA:293181 |
|
| OMIM:301072 |
|
| OMIM:300868 |
|
| OMIM:300818 |
|
| ORPHA:447 |
|
| ORPHA:3451 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP001689
- Gene Name
- phosphatidylinositol glycan anchor biosynthesis, class A
Ortholog
| Species | Gene ID | OrthoDB | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|---|
| 18700 | MGI:99461 | MOUSE66170 | ||
| 37020 | FB:FBgn0034270 | |||
| 174386 | WB:WBGene00008431 | |||
| 363464 | RGD:1589723 | RATNO45598 | ||
| 465507 | 9598_0:0058bc | PANTR45534 | ||
| 712514 | MACMU47935 | |||
| 791759 | ZFIN:ZDB-GENE-040426-1086 | DANRE44974 | ||
| 855928 | SGD:S000006096 | |||
| 100085170 | ORNAN06673 | |||
| 100156880 | PIGXX36954 |
