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phosphatidylinositol glycan anchor biosynthesis class A

Summary

Gene Symbol

PIGA

Aliases

GPI3
GPI3 (SPT14) homolog (S. cerevisiae)
PIG-A
Phosphatidylinositol N-acetylglucosaminyltransferase subunit A
paroxysmal nocturnal hemoglobinuria

Organism

Homo sapiens (human)

External Links

NCBI Gene

5277

GGDB ID

gg215

HGNC

8957

mRNA

NM_002641

map

Xp22.1, Xp22.2 (OMIM)

Protein

NP_002632

OMIM

311770

KEGG Gene ID

hsa:5277

PubChem

5277

Alliance of Genome Resources

HGNC:8957

JoGo

PIGA

TogoVar

PIGA

Annotation

Keyword

Alternative splicing
Disease variant
Endoplasmic reticulum
Epilepsy
GPI-anchor biosynthesis
Glycoprotein
Glycosyltransferase
Intellectual disability
Lipid metabolism
Phosphoprotein
Proteomics identification
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P37287	GlcNAc-PI synthesis protein Phosphatidylinositol-glycan biosynthesis class A protein
A0A2K4ZA02	GlcNAc-PI synthesis protein Phosphatidylinositol-glycan biosynthesis class A protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
GPI anchor biosynthetic process	TAS
GPI anchor biosynthetic process	IBA
GPI anchor biosynthetic process	IEA
preassembly of GPI anchor in ER membrane
cellular response to leukemia inhibitory factor	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

GPI anchor biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

GPI anchor biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

GPI anchor biosynthetic process

macromolecule modification [inference]

protein modification process [inference]

protein lipidation [inference]

GPI anchor biosynthetic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

GPI anchor biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

response to leukemia inhibitory factor [inference]

cellular response to leukemia inhibitory factor

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	IDA	16162815
glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	IBA
glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	IPI	16162815
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IDA	16162815

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex

endoplasmic reticulum protein-containing complex [inference]

glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex

catalytic complex [inference]

transferase complex [inference]

glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	10944123 16162815 33961781 8900170 9463366
UDP-glycosyltransferase activity	TAS
phosphatidylinositol N-acetylglucosaminyltransferase activity	TAS	16162815
phosphatidylinositol N-acetylglucosaminyltransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity

acetylglucosaminyltransferase activity [inference]

phosphatidylinositol N-acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

phosphatidylinositol N-acetylglucosaminyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

GlycoGene Database (GGDB)

GGDB ID

gg215

Gene Symbol

PIGA

KEGG BRITE Database

Orthology

K03857

Name

phosphatidylinositol N-acetylglucosaminyltransferase subunit A [EC:2.4.1.198]

References

7680492

Rhea

RHEA:14789

UDP-N-acetyl-α-D-glucosamine + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)

H⁺ + a 6-(N-acetyl-α-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + UDP

Enzyme

2.4.1.198

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060284	paroxysmal nocturnal hemoglobinuria	Glyco-Disease Genes Database Alliance of Genome Resources
DOID:0080139	multiple congenital anomalies-hypotonia-seizures syndrome 2	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of **168** in total

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HPO ID	HPO Term
HP:0000054	Micropenis
HP:0000076	Vesicoureteral reflux
HP:0000081	Duplicated collecting system
HP:0000083	Renal insufficiency
HP:0000093	Proteinuria
HP:0000160	Narrow mouth
HP:0000201	Pierre-Robin sequence
HP:0000207	Triangular mouth
HP:0000212	Gingival overgrowth
HP:0000218	High palate

Displaying **all 6** entries
Disease ID	Disease Name
OMIM:300868	multiple congenital anomalies-hypotonia-seizures syndrome 2
OMIM:301072	ferro-cerebro-cutaneous syndrome
OMIM:300818	paroxysmal nocturnal hemoglobinuria 1
ORPHA:3451	West syndrome
ORPHA:447	paroxysmal nocturnal hemoglobinuria
ORPHA:293181	malignant migrating partial seizures of infancy

PubChem Disease

GHR Health Conditions

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001689
Gene Name: phosphatidylinositol glycan anchor biosynthesis, class A

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements