GlyCosmos Portal

Annotation

Keyword

Alternative splicing
Disease variant
Endoplasmic reticulum
Epilepsy
GPI-anchor biosynthesis
Glycoprotein
Glycosyltransferase
Intellectual disability
Lipid metabolism
Phosphoprotein
Reference proteome
Transmembrane helix

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P37287	GlcNAc-PI synthesis protein Phosphatidylinositol-glycan biosynthesis class A protein
A0A2K4ZA02	GlcNAc-PI synthesis protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
GPI anchor biosynthetic process	TAS
GPI anchor biosynthetic process	IBA
GPI anchor biosynthetic process	IEA
preassembly of GPI anchor in ER membrane
cellular response to leukemia inhibitory factor	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

GPI anchor biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

GPI anchor biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

GPI anchor biosynthetic process

macromolecule modification [inference]

protein modification process [inference]

protein lipidation [inference]

GPI anchor biosynthetic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

GPI anchor biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

preassembly of GPI anchor in ER membrane

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

response to stimulus [inference]

response to chemical [inference]

response to organic substance [inference]

response to cytokine [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

response to leukemia inhibitory factor [inference]

cellular response to leukemia inhibitory factor

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to cytokine stimulus [inference]

cellular response to leukemia inhibitory factor

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	IDA	16162815
glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	IBA
glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	IPI	16162815
endoplasmic reticulum membrane	TAS
endoplasmic reticulum membrane	IDA	16162815

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex

endoplasmic reticulum protein-containing complex [inference]

glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex

catalytic complex [inference]

transferase complex [inference]

glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex

cellular anatomical entity [inference]

membrane

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	10944123 16162815 33961781 8900170 9463366
UDP-glycosyltransferase activity	TAS
phosphatidylinositol N-acetylglucosaminyltransferase activity	TAS	16162815
phosphatidylinositol N-acetylglucosaminyltransferase activity	IBA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

glycosyltransferase activity [inference]

UDP-glycosyltransferase activity

acetylglucosaminyltransferase activity [inference]

phosphatidylinositol N-acetylglucosaminyltransferase activity

hexosyltransferase activity [inference]

acetylglucosaminyltransferase activity [inference]

phosphatidylinositol N-acetylglucosaminyltransferase activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

phosphatidylinositol

Functional Category

E: Amino acid transport and metabolism
M: Cell wall/membrane/envelope biogenesis
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
phosphatidylinositol N-acetylglucosaminyltransferase activity
transferase activity

Displaying **all 3** entries
InterPro
Glycosyl transferase, family 1
PIGA, GPI anchor biosynthesis
Phosphatidylinositol N-acetylglucosaminyltransferase subunit PIG-A/GPI3

GlycoGene Database (GGDB)

GGDB ID

gg215

Gene Symbol

PIGA

KEGG BRITE Database

Orthology

K03857

Name

phosphatidylinositol N-acetylglucosaminyltransferase subunit A [EC:2.4.1.198]

References

7680492

Rhea

RHEA:14789

UDP-N-acetyl-α-D-glucosamine + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)

H⁺ + a 6-(N-acetyl-α-D-glucosaminyl)-1-phosphatidyl-1D-myo-inositol + UDP

Enzyme

2.4.1.198

PMID

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0060284	paroxysmal nocturnal hemoglobinuria	Glyco-Disease Genes Database Alliance of Genome Resources
DOID:0080139	multiple congenital anomalies-hypotonia-seizures syndrome 2	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **1 - 10** of **168** in total

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HPO ID	HPO Term
HP:0000054	Micropenis
HP:0000076	Vesicoureteral reflux
HP:0000081	Duplicated collecting system
HP:0000083	Renal insufficiency
HP:0000093	Proteinuria
HP:0000160	Narrow mouth
HP:0000201	Pierre-Robin sequence
HP:0000207	Triangular mouth
HP:0000212	Gingival overgrowth
HP:0000218	High palate

Displaying **all 6** entries
Disease ID	Disease Name
ORPHA:3451	West syndrome
OMIM:300868	multiple congenital anomalies-hypotonia-seizures syndrome 2
OMIM:300818	paroxysmal nocturnal hemoglobinuria 1
ORPHA:447	paroxysmal nocturnal hemoglobinuria
OMIM:301072	ferro-cerebro-cutaneous syndrome
ORPHA:293181	malignant migrating partial seizures of infancy

PubChem Disease

GHR Health Conditions

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001689
Gene Name: phosphatidylinositol glycan anchor biosynthesis, class A

Ortholog

Displaying entries **1 - 10** of 89 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	5277	Xenbase:XB-GENE-996765
Mus musculus	18700	Xenbase:XB-GENE-996765	MOUSE66170
Xenopus tropicalis	37020	Xenbase:XB-GENE-996765
Xenopus tropicalis	174386	Xenbase:XB-GENE-996765
Rattus norvegicus	363464	Xenbase:XB-GENE-996765	RATNO45598
Pan troglodytes	465507		PANTR45534
Macaca mulatta	712514		MACMU47935
Danio rerio	791759	Xenbase:XB-GENE-996765	DANRE44974
Xenopus tropicalis	855928	Xenbase:XB-GENE-996765
Ornithorhynchus anatinus	100085170		ORNAN06673

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Guidelines

Summary

External Links

Annotation

OrthoDB (Group)

GlycoGene Database (GGDB)

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements