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Guidelines

MIRAGE

phosphatidylinositol glycan anchor biosynthesis class C

Summary

Gene Symbol

PIGC

Aliases

GPI2
PIG-C
phosphatidylinositol N-acetylglucosaminyltransferase subunit C

Organism

Homo sapiens (human)

External Links

NCBI Gene

5279

GGDB ID

gg214

HGNC

8960

mRNA

NM_153747

map

1q23-q25, 1q24.3 (OMIM)

Protein

NP_714969

OMIM

601730

KEGG Gene ID

hsa:5279

PubChem

5279

Alliance of Genome Resources

HGNC:8960

Annotation

Keyword

Disease variant
Endoplasmic reticulum
GPI-anchor biosynthesis
Intellectual disability
Reference proteome
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q92535	Phosphatidylinositol-glycan biosynthesis class C protein

Annotation information from UniProt.

Gene Ontology (GO)

Displaying 1 entry
GO Term	Evidence Code	PMID
GPI anchor biosynthetic process	IDA IEA IMP	16162815 27694521

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

GPI anchor biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

GPI anchor biosynthetic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

GPI anchor biosynthetic process

macromolecule modification [inference]

protein modification process [inference]

protein lipidation [inference]

GPI anchor biosynthetic process

carbohydrate derivative metabolic process [inference]

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

liposaccharide metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein lipidation [inference]

GPI anchor biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

carbohydrate derivative biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

glycolipid metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

membrane lipid biosynthetic process [inference]

glycolipid biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol metabolic process [inference]

GPI anchor metabolic process [inference]

GPI anchor biosynthetic process

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

GPI anchor biosynthetic process

Displaying **all 2** entries
GO Term	Evidence Code	PMID
glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex	IBA IDA IPI	10944123 16162815
endoplasmic reticulum membrane	IDA TAS	16162815

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex

endoplasmic reticulum protein-containing complex [inference]

glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex

catalytic complex [inference]

transferase complex [inference]

glycosylphosphatidylinositol-N-acetylglucosaminyltransferase (GPI-GnT) complex

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

Displaying **all 2** entries
GO Term	Evidence Code	PMID
catalytic activity		8806613
protein binding	IPI	10944123 9463366

GO Hierarchy

molecular function

catalytic activity

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

GlycoGene Database (GGDB)

GGDB ID

gg214

Gene Symbol

PIGC

KEGG BRITE Database

Orthology

K03859

Name

phosphatidylinositol N-acetylglucosaminyltransferase subunit C

References

8806613

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0081223	glycosylphosphatidylinositol biosynthesis defect 16	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying **all 7** entries
HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0001249	Intellectual disability
HP:0001250	Seizure
HP:0001263	Global developmental delay
HP:0002465	Poor speech
HP:0003155	Elevated circulating alkaline phosphatase concentration
HP:0003593	Infantile onset

Displaying 1 entry
Disease ID	Disease Name
OMIM:617816	glycosylphosphatidylinositol biosynthesis defect 16

PubChem Disease

MedGen Diseases

Glycosylphosphatidylinositol biosynthesis defect 16

OMIM Phenotypes

GLYCOSYLPHOSPHATIDYLINOSITOL BIOSYNTHESIS DEFECT 16; GPIBD16

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000545
Gene Name: phosphatidylinositol glycan anchor biosynthesis, class C

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Acknowledgements

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: February 17, 2025