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polymeric immunoglobulin receptor

Summary

Gene Symbol

PIGR

Organism

Homo sapiens (human)

External Links

NCBI Gene

5284

PubChem

5284

Alliance of Genome Resources

HGNC:8968

Annotation

Keyword

3D-structure
Cell membrane
Direct protein sequencing
Disulfide bond
Glycoprotein
Immunoglobulin domain
Phosphoprotein
Reference proteome
Repeat
Secreted
Signal
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
P01833	Hepatocellular carcinoma-associated protein TB6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
detection of chemical stimulus involved in sensory perception of bitter taste	IDA	24248522
immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor	IDA	10229845 22022593 9379029
immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor	IBA
signal transduction	IBA
epidermal growth factor receptor signaling pathway	IDA	22022593

GO Hierarchy

biological process

cellular process [inference]

signal transduction

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

vesicle-mediated transport [inference]

transcytosis [inference]

immunoglobulin transcytosis in epithelial cells [inference]

immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering

multicellular organismal process [inference]

transcytosis [inference]

immunoglobulin transcytosis in epithelial cells [inference]

immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor

response to stimulus [inference]

detection of stimulus [inference]

detection of chemical stimulus [inference]

detection of chemical stimulus involved in sensory perception [inference]

detection of chemical stimulus involved in sensory perception of taste [inference]

detection of chemical stimulus involved in sensory perception of bitter taste

detection of stimulus involved in sensory perception [inference]

detection of chemical stimulus involved in sensory perception [inference]

detection of chemical stimulus involved in sensory perception of taste [inference]

detection of chemical stimulus involved in sensory perception of bitter taste

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

transcytosis [inference]

immunoglobulin transcytosis in epithelial cells [inference]

immunoglobulin transcytosis in epithelial cells mediated by polymeric immunoglobulin receptor

cellular localization [inference]

localization within membrane [inference]

protein localization to membrane [inference]

receptor clustering

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to membrane [inference]

receptor clustering

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway

regulation of response to stimulus [inference]

regulation of immune response [inference]

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway

regulation of cellular process [inference]

signal transduction

immune response-regulating signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway

cell surface receptor signaling pathway [inference]

immune response-regulating cell surface receptor signaling pathway [inference]

Fc receptor signaling pathway

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway [inference]

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
extracellular space	IDA	24248522
extracellular space	HDA	16502470 22664934 23580065
plasma membrane	TAS
plasma membrane	IDA	22022593 9379029
plasma membrane	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

immunoglobulin complex [inference]

immunoglobulin complex, circulating [inference]

IgA immunoglobulin complex, circulating [inference]

polymeric IgA immunoglobulin complex [inference]

secretory IgA immunoglobulin complex

IgA immunoglobulin complex [inference]

IgA immunoglobulin complex, circulating [inference]

polymeric IgA immunoglobulin complex [inference]

secretory IgA immunoglobulin complex

receptor complex

cellular anatomical entity [inference]

extracellular space

membrane [inference]

plasma membrane

organelle membrane [inference]

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

secretory granule membrane [inference]

azurophil granule membrane

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane [inference]

azurophil granule membrane

secretory granule membrane [inference]

azurophil granule membrane

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 3** entries
GO Term	Evidence Code	PMID
polymeric immunoglobulin binding	IDA	32029689 36949194
polymeric immunoglobulin receptor activity	IDA	22022593
transmembrane signaling receptor activity	IBA

GO Hierarchy

molecular function

binding [inference]

protein-containing complex binding [inference]

immunoglobulin binding [inference]

polymeric immunoglobulin binding

molecular transducer activity [inference]

signaling receptor activity [inference]

transmembrane signaling receptor activity

immunoglobulin receptor activity [inference]

polymeric immunoglobulin receptor activity

immune receptor activity [inference]

immunoglobulin receptor activity [inference]

polymeric immunoglobulin receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

polymeric immunoglobulin receptor

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
InterPro
Immunoglobulin V-set domain
Immunoglobulin subtype
Immunoglobulin-like domain superfamily
Immunoglobulin-like domain
Immunoglobulin-like fold

Ortholog

Displaying entries **1 - 10** of 53 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	5284	Xenbase:XB-GENE-981188
Mus musculus	18703	Xenbase:XB-GENE-981188	MOUSE28444
Rattus norvegicus	25046	Xenbase:XB-GENE-981188	RATNO06408
Bos taurus	281401		BOVIN07936
Sus scrofa	397315		PIGXX35958
Pan troglodytes	457685		PANTR23543
Canis lupus familiaris	474357		CANLF17084
Macaca mulatta	694638		MACMU25438
Monodelphis domestica	100015139		MONDO16016
Ornithorhynchus anatinus	100077431		ORNAN24268