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CLN5 intracellular trafficking protein

Summary

Gene Symbol

CLN5

Organism

Bos taurus (cattle)

External Links

NCBI Gene: 529186
PubChem: 529186

Annotation

Keyword

Disulfide bond
Glycoprotein
Hydrolase
Lysosome
Neuronal ceroid lipofuscinosis
Reference proteome
Signal-anchor
Transferase
Transmembrane helix

Proteins

Displaying 1 entry
UniProt	Protein Name
Q1ZYR0	Ceroid-lipofuscinosis neuronal protein 5 Palmitoyl protein thioesterase CLN5 S-depalmitoylase CLN5

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
brain development
retrograde transport, endosome to Golgi
lysosomal lumen acidification
neurogenesis
positive regulation of GTP binding

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

amide metabolic process [inference]

peptide metabolic process [inference]

signal peptide processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

signal peptide processing

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signal peptide processing

protein maturation [inference]

protein processing [inference]

signal peptide processing

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signal peptide processing

protein maturation [inference]

protein processing [inference]

signal peptide processing

glycosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signal peptide processing

protein maturation [inference]

protein processing [inference]

signal peptide processing

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

signal peptide processing

protein metabolic process [inference]

proteolysis [inference]

protein processing [inference]

signal peptide processing

protein maturation [inference]

protein processing [inference]

signal peptide processing

cellular process [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

cellular localization [inference]

intracellular transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

vacuole organization [inference]

lytic vacuole organization [inference]

lysosome organization

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

brain development

cellular developmental process [inference]

cell differentiation [inference]

neurogenesis

homeostatic process [inference]

cellular homeostasis [inference]

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

chemical homeostasis [inference]

monoatomic ion homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

monoatomic cation homeostasis [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

intracellular chemical homeostasis [inference]

intracellular monoatomic ion homeostasis [inference]

intracellular monoatomic cation homeostasis [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi

intracellular transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

establishment of localization in cell [inference]

intracellular transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

cellular localization [inference]

intracellular transport [inference]

endosomal transport [inference]

retrograde transport, endosome to Golgi

cytosolic transport [inference]

retrograde transport, endosome to Golgi

biological regulation [inference]

regulation of pH [inference]

regulation of cellular pH [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

regulation of biological quality [inference]

regulation of intracellular pH [inference]

regulation of lysosomal lumen pH [inference]

lysosomal lumen acidification

intracellular pH reduction [inference]

vacuolar acidification [inference]

lysosomal lumen acidification

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of binding [inference]

positive regulation of GTP binding

regulation of binding [inference]

positive regulation of binding [inference]

positive regulation of GTP binding

regulation of GTP binding [inference]

positive regulation of GTP binding

Displaying entries **6 - 7** of 7 in total

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GO Term	Evidence Code	PMID
perinuclear region of cytoplasm
lysosome	IEA	22301074 30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

organelle membrane [inference]

bounding membrane of organelle [inference]

vacuolar membrane [inference]

lytic vacuole membrane [inference]

lysosomal membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

perinuclear region of cytoplasm

Displaying **all 4** entries
GO Term	Evidence Code	PMID
hydrolase activity, acting on glycosyl bonds	IEA	30032202
mannose binding
long-chain acyl-CoA hydrolase activity
bis(monoacylglycero)phosphate synthase activity

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

acyltransferase activity [inference]

acyltransferase activity, transferring groups other than amino-acyl groups [inference]

bis(monoacylglycero)phosphate synthase activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

thiolester hydrolase activity [inference]

CoA hydrolase activity [inference]

acyl-CoA hydrolase activity [inference]

long-chain acyl-CoA hydrolase activity

hydrolase activity, acting on glycosyl bonds

binding [inference]

carbohydrate binding [inference]

monosaccharide binding [inference]

mannose binding

small molecule binding [inference]

monosaccharide binding [inference]

mannose binding

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying entries **21 - 30** of 76 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Macaca nemestrina	105481732		MACNE17167
Papio anubis	101009061		PAPAN10764
Mandrillus leucophaeus	105554268		MANLE30855
Pan paniscus	100983703		PANPA11220
Pan troglodytes	452607		PANTR07917
Pongo abelii	100454233		PONAB07018
Homo sapiens	1203		HUMAN17313
Canis lupus familiaris	485498		CANLF08765
Ursus americanus	123801089		URSAM12985
Mustela putorius furo	101691219		MUSPF12673

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Last updated: August 19, 2024