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phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma

Summary

Gene Symbol

PIK3CG

Organism

Homo sapiens (human)

External Links

NCBI Gene

5294

HGNC

8978

KEGG Gene ID

hsa:5294

PubChem

5294

Alliance of Genome Resources

HGNC:8978

Annotation

Keyword

3D-structure
ATP-binding
Angiogenesis
Cell membrane
Chemotaxis
Cytoplasm
Disease variant
Endocytosis
Immunity
Inflammatory response
Kinase
Lipid metabolism
Phosphoprotein
Reference proteome
Serine/threonine-protein kinase

Proteins

Displaying **all 2** entries
UniProt	Protein Name
P48736	Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit gamma Phosphoinositide-3-kinase catalytic gamma polypeptide Serine/threonine protein kinase PIK3CG p120-PI3K
A8K9G9

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **31 - 35** of 41 in total

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GO Term	Evidence Code	PMID
positive regulation of acute inflammatory response	IEA
T cell chemotaxis		18278175
phosphatidylinositol-mediated signaling	IBA
negative regulation of cardiac muscle contraction		19147653
hepatocyte apoptotic process	IEA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

respiratory burst involved in defense response

leukocyte degranulation [inference]

mast cell degranulation

immune response

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation

T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation

leukocyte migration [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

lymphocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

cellular extravasation [inference]

neutrophil extravasation

mononuclear cell migration [inference]

dendritic cell migration [inference]

dendritic cell chemotaxis

lymphocyte migration [inference]

lymphocyte chemotaxis [inference]

T cell migration [inference]

T cell chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

respiratory burst [inference]

respiratory burst involved in defense response

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

organic substance biosynthetic process [inference]

lipid biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

cellular process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation

T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation

cell adhesion [inference]

cell-cell adhesion [inference]

homotypic cell-cell adhesion [inference]

platelet aggregation

signal transduction [inference]

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

sphingolipid mediated signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

cell death [inference]

programmed cell death [inference]

apoptotic process [inference]

epithelial cell apoptotic process [inference]

hepatocyte apoptotic process

cell population proliferation [inference]

leukocyte proliferation [inference]

mononuclear cell proliferation [inference]

lymphocyte proliferation [inference]

T cell proliferation

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

mast cell degranulation

endocytosis

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphorylation

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

organophosphate biosynthetic process [inference]

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

cellular biosynthetic process [inference]

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

cellular lipid metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phospholipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

phosphatidylinositol metabolic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

glycerolipid biosynthetic process [inference]

glycerophospholipid biosynthetic process [inference]

phosphatidylinositol biosynthetic process [inference]

phosphatidylinositol phosphate biosynthetic process

phosphatidylinositol-3-phosphate biosynthetic process

cell motility [inference]

cell migration

leukocyte migration [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

lymphocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

cellular extravasation [inference]

neutrophil extravasation

mononuclear cell migration [inference]

dendritic cell migration [inference]

dendritic cell chemotaxis

lymphocyte migration [inference]

lymphocyte chemotaxis [inference]

T cell migration [inference]

T cell chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

lymphocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

mast cell degranulation

multicellular organismal process [inference]

cell activation [inference]

leukocyte activation [inference]

lymphocyte activation [inference]

T cell activation

T cell proliferation

lymphocyte proliferation [inference]

T cell proliferation

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

angiogenesis

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

dendritic cell chemotaxis

lymphocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to stimulus [inference]

response to stress [inference]

defense response [inference]

inflammatory response

defense response to other organism [inference]

innate immune response

immune response

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

response to endogenous stimulus [inference]

cellular response to endogenous stimulus [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

response to chemical [inference]

response to organic substance [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

response to organic cyclic compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to organic cyclic compound [inference]

cellular response to cAMP

response to organophosphorus [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

response to nitrogen compound [inference]

response to organonitrogen compound [inference]

response to purine-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

response to oxygen-containing compound [inference]

response to cAMP [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

cellular response to stimulus [inference]

cellular response to chemical stimulus [inference]

cellular response to organic substance [inference]

cellular response to organic cyclic compound [inference]

cellular response to cAMP

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to nitrogen compound [inference]

cellular response to organonitrogen compound [inference]

cellular response to cAMP

cellular response to oxygen-containing compound [inference]

cellular response to cAMP

localization [inference]

establishment of localization [inference]

transport [inference]

vesicle-mediated transport [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

mast cell degranulation

endocytosis

secretion [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

mast cell degranulation

import into cell [inference]

endocytosis

export from cell [inference]

secretion by cell [inference]

exocytosis [inference]

regulated exocytosis [inference]

leukocyte degranulation [inference]

mast cell degranulation

establishment of localization in cell [inference]

leukocyte degranulation [inference]

mast cell degranulation

establishment of organelle localization [inference]

mast cell degranulation

organelle localization [inference]

vesicle localization [inference]

secretory granule localization

establishment of organelle localization [inference]

mast cell degranulation

vacuolar localization [inference]

lysosome localization [inference]

mast cell degranulation

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of lipid catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of lipid catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of lipid catabolic process [inference]

negative regulation of triglyceride catabolic process

regulation of cellular catabolic process [inference]

regulation of triglyceride catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of cellular catabolic process [inference]

negative regulation of triglyceride catabolic process

regulation of lipid catabolic process [inference]

regulation of triglyceride catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of lipid catabolic process [inference]

negative regulation of triglyceride catabolic process

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of cellular catabolic process [inference]

regulation of triglyceride catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of cellular catabolic process [inference]

negative regulation of triglyceride catabolic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of triglyceride metabolic process [inference]

regulation of triglyceride catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

regulation of nitrogen compound metabolic process [inference]

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of primary metabolic process [inference]

regulation of lipid metabolic process [inference]

negative regulation of lipid metabolic process [inference]

negative regulation of lipid catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

regulation of lipid catabolic process [inference]

regulation of triglyceride catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of lipid catabolic process [inference]

negative regulation of triglyceride catabolic process

regulation of triglyceride metabolic process [inference]

regulation of triglyceride catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

regulation of protein metabolic process [inference]

regulation of protein modification process [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of signaling [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rac protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of localization [inference]

regulation of transport [inference]

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport

regulation of monoatomic ion transport [inference]

regulation of metal ion transport [inference]

regulation of calcium ion transport [inference]

regulation of calcium ion transmembrane transport

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of biological process [inference]

positive regulation of metabolic process [inference]

positive regulation of biosynthetic process [inference]

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule metabolic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of nitrogen compound metabolic process [inference]

positive regulation of protein metabolic process [inference]

positive regulation of protein modification process [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of lipid catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of lipid metabolic process [inference]

negative regulation of lipid catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of fibroblast apoptotic process

negative regulation of multicellular organismal process [inference]

negative regulation of muscle contraction [inference]

negative regulation of striated muscle contraction [inference]

negative regulation of cardiac muscle contraction

negative regulation of blood circulation [inference]

negative regulation of heart contraction [inference]

negative regulation of cardiac muscle contraction

regulation of response to stimulus [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rac protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of response to external stimulus [inference]

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

regulation of inflammatory response [inference]

regulation of acute inflammatory response [inference]

positive regulation of acute inflammatory response

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

positive regulation of response to external stimulus [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

regulation of response to stress [inference]

regulation of defense response [inference]

positive regulation of defense response [inference]

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

regulation of inflammatory response [inference]

regulation of acute inflammatory response [inference]

positive regulation of acute inflammatory response

positive regulation of inflammatory response [inference]

positive regulation of acute inflammatory response

regulation of developmental process [inference]

regulation of anatomical structure morphogenesis [inference]

regulation of angiogenesis

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

sphingolipid mediated signaling pathway [inference]

sphingosine-1-phosphate receptor signaling pathway

regulation of cell communication [inference]

regulation of signal transduction [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of intracellular signal transduction [inference]

regulation of MAPK cascade [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity

regulation of small GTPase mediated signal transduction [inference]

regulation of Ras protein signal transduction [inference]

regulation of Rac protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction [inference]

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

regulation of cell adhesion [inference]

regulation of cell adhesion mediated by integrin

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

regulation of cellular catabolic process [inference]

regulation of triglyceride catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of cellular catabolic process [inference]

negative regulation of triglyceride catabolic process

regulation of phosphorus metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of phosphate metabolic process [inference]

regulation of phosphorylation [inference]

regulation of protein phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of triglyceride metabolic process [inference]

regulation of triglyceride catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

regulation of transmembrane transport [inference]

regulation of monoatomic ion transmembrane transport [inference]

regulation of monoatomic cation transmembrane transport [inference]

regulation of calcium ion transmembrane transport

regulation of programmed cell death [inference]

regulation of apoptotic process [inference]

negative regulation of apoptotic process [inference]

negative regulation of fibroblast apoptotic process

regulation of fibroblast apoptotic process [inference]

negative regulation of fibroblast apoptotic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of fibroblast apoptotic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of intracellular signal transduction [inference]

positive regulation of MAPK cascade [inference]

positive regulation of MAP kinase activity

positive regulation of small GTPase mediated signal transduction [inference]

positive regulation of Ras protein signal transduction [inference]

positive regulation of Rac protein signal transduction

positive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction

positive regulation of cellular metabolic process [inference]

positive regulation of phosphorus metabolic process [inference]

positive regulation of phosphate metabolic process [inference]

positive regulation of phosphorylation [inference]

positive regulation of protein phosphorylation [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of cellular biosynthetic process [inference]

positive regulation of macromolecule biosynthetic process [inference]

positive regulation of gene expression [inference]

positive regulation of cytokine production

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of triglyceride metabolic process [inference]

negative regulation of triglyceride catabolic process

negative regulation of programmed cell death [inference]

negative regulation of apoptotic process [inference]

negative regulation of fibroblast apoptotic process

regulation of cell motility [inference]

regulation of cell migration [inference]

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration [inference]

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

positive regulation of cytokine production

regulation of epithelial cell migration [inference]

regulation of endothelial cell migration [inference]

positive regulation of endothelial cell migration

positive regulation of epithelial cell migration [inference]

positive regulation of endothelial cell migration

regulation of system process [inference]

regulation of muscle system process [inference]

regulation of muscle contraction [inference]

regulation of striated muscle contraction [inference]

negative regulation of striated muscle contraction [inference]

negative regulation of cardiac muscle contraction

regulation of cardiac muscle contraction [inference]

negative regulation of cardiac muscle contraction

negative regulation of muscle contraction [inference]

negative regulation of striated muscle contraction [inference]

negative regulation of cardiac muscle contraction

regulation of blood circulation [inference]

regulation of heart contraction [inference]

negative regulation of heart contraction [inference]

negative regulation of cardiac muscle contraction

regulation of cardiac muscle contraction [inference]

negative regulation of cardiac muscle contraction

negative regulation of blood circulation [inference]

negative regulation of heart contraction [inference]

negative regulation of cardiac muscle contraction

positive regulation of multicellular organismal process [inference]

positive regulation of cytokine production

negative regulation of multicellular organismal process [inference]

negative regulation of muscle contraction [inference]

negative regulation of striated muscle contraction [inference]

negative regulation of cardiac muscle contraction

negative regulation of blood circulation [inference]

negative regulation of heart contraction [inference]

negative regulation of cardiac muscle contraction

regulation of multicellular organismal development [inference]

regulation of vasculature development [inference]

regulation of angiogenesis

regulation of biological quality [inference]

positive regulation of cytosolic calcium ion concentration

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of transferase activity [inference]

regulation of kinase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

regulation of protein serine/threonine kinase activity [inference]

regulation of MAP kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

positive regulation of transferase activity [inference]

positive regulation of kinase activity [inference]

positive regulation of protein kinase activity [inference]

positive regulation of protein serine/threonine kinase activity [inference]

positive regulation of MAP kinase activity

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GO Term	Evidence Code	PMID
phosphatidylinositol 3-kinase complex, class IA	EXP IBA	10358071
cytosol	IDA TAS
cytoplasm	IBA IDA	12507995
phosphatidylinositol 3-kinase complex, class IB	IBA IDA	12507995
plasma membrane	IBA IDA

GO Hierarchy

cellular component

protein-containing complex [inference]

membrane protein complex [inference]

phosphatidylinositol 3-kinase complex [inference]

phosphatidylinositol 3-kinase complex, class I [inference]

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

phosphatidylinositol 3-kinase complex [inference]

phosphatidylinositol 3-kinase complex, class I [inference]

cellular anatomical entity [inference]

membrane

plasma membrane

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GO Term	Evidence Code	PMID
kinase activity	IDA	25327288
ephrin receptor binding	IPI	11416136
1-phosphatidylinositol-3-kinase activity	IBA IDA TAS	11277933 16123124 17290298
protein serine/threonine kinase activity	IEA
protein serine kinase activity	IDA	12502714

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity

lipid kinase activity [inference]

phosphatidylinositol kinase activity [inference]

protein kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

protein kinase activity

phosphatidylinositol kinase activity [inference]

catalytic activity, acting on a protein [inference]

protein kinase activity

binding [inference]

protein binding

signaling receptor binding [inference]

ephrin receptor binding

identical protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

KEGG BRITE Database

Orthology

K21289

Name

phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit gamma [EC:2.7.1.153]

References

7624799

Rhea

RHEA:46608

ATP

H⁺ + ADP

Enzyme

PMID

RHEA:21292

ATP + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)

H⁺ + ADP + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4,5-trisphosphate)

Enzyme

2.7.1.153

PMID

RHEA:17989

ATP

H⁺ + ADP

Enzyme

PMID

RHEA:18373

ATP + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)

H⁺ + ADP + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3,4-bisphosphate)

Enzyme

2.7.1.154

PMID

RHEA:12709

ATP + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)

H⁺ + ADP + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-3-phosphate)

Enzyme

2.7.1.137

PMID

Disease

Disease Ontology

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DO ID	Disease Name	Source
DOID:10941	intracranial aneurysm	DisGeNET
DOID:10952	nephritis	DisGeNET
DOID:10965	spastic diplegia	DisGeNET
DOID:10966	lipoid nephrosis	DisGeNET
DOID:10968	spastic monoplegia	DisGeNET
DOID:10969	hemiplegia	DisGeNET
DOID:10970	spastic quadriplegic cerebral palsy	DisGeNET
DOID:11054	urinary bladder cancer	DisGeNET DisGeNET DisGeNET
DOID:1107	esophageal carcinoma	DisGeNET DisGeNET DisGeNET
DOID:11120	psychologic dyspareunia	DisGeNET

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000010	Recurrent urinary tract infections
HP:0000403	Recurrent otitis media
HP:0000964	Eczematoid dermatitis
HP:0001252	Hypotonia
HP:0001433	Hepatosplenomegaly
HP:0001581	Recurrent skin infections
HP:0001742	Nasal congestion
HP:0001744	Splenomegaly
HP:0001873	Thrombocytopenia

Displaying 1 entry
Disease ID	Disease Name
OMIM:619802	immunodeficiency 97 with autoinflammation

PubChem Disease

MedGen Diseases

Immunodeficiency 97 with autoinflammation

OMIM Phenotypes

IMMUNODEFICIENCY 97 WITH AUTOINFLAMMATION; IMD97

KEGG Diseases

Combined immunodeficiency

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP000468
Gene Name: phosphatidylinositol-4,5-bisphosphate 3-kinase, catalytic subunit gamma

Ortholog

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Species	Gene ID	Orthologous MAtrix
Felis catus	101096215	FELCA03042
Panthera leo	122206263	PANLE22381
Tursiops truncatus	101336571	TURTR01860
Balaenoptera musculus	118900854	BALMU12651
Loxodonta africana	100673566	LOXAF17782
Equus caballus	100050532	HORSE33500
Sus scrofa	396979	PIGXX36424
Bos taurus	530001	BOVIN27946
Capra hircus	102173256	CAPHI23797
Ovis aries	101102896	SHEEP15440

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements