GlyCosmos Portal

Displaying **all 5** entries
GO Term	Evidence Code	PMID
kinase activity	IDA	25327288
1-phosphatidylinositol 4-kinase activity	IBA ISS TAS
ATP binding	IEA
protein binding	IPI	14676841 15607035 21238945 21297162 23675303 23935497 25608530 26571211
cadherin binding	HDA	25468996

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

kinase activity

lipid kinase activity [inference]

phosphatidylinositol kinase activity [inference]

1-phosphatidylinositol 4-kinase activity

phosphotransferase activity, alcohol group as acceptor [inference]

phosphatidylinositol kinase activity [inference]

1-phosphatidylinositol 4-kinase activity

binding [inference]

protein binding

cell adhesion molecule binding [inference]

cadherin binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ion binding [inference]

anion binding [inference]

purine ribonucleoside triphosphate binding [inference]

ATP binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding [inference]

purine nucleotide binding [inference]

adenyl nucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

purine ribonucleoside triphosphate binding [inference]

ATP binding

carbohydrate derivative binding [inference]

ribonucleotide binding [inference]

purine ribonucleotide binding [inference]

adenyl ribonucleotide binding [inference]

ATP binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000241973

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K00888

Name

phosphatidylinositol 4-kinase A [EC:2.7.1.67]

References

Rhea

RHEA:19877

ATP + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol)

H⁺ + ADP + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol 4-phosphate)

Enzyme

2.7.1.67

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 32 in total

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DO ID	Disease Name	Source
DOID:0060337	CEDNIK syndrome	DisGeNET
DOID:0060413	chromosome 22q11.2 deletion syndrome, distal	Alliance of Genome Resources
DOID:0060787	hypomyelinating leukodystrophy 2	DisGeNET
DOID:0080348	Alzheimer's disease 1	DisGeNET
DOID:0110035	Alzheimer's disease 2	DisGeNET
DOID:0110037	Alzheimer's disease 5	DisGeNET
DOID:0110038	Alzheimer's disease 6	DisGeNET
DOID:0110039	Alzheimer's disease 7	DisGeNET
DOID:0110041	Alzheimer's disease 8	DisGeNET
DOID:0110043	Alzheimer's disease 10	DisGeNET

The Human Phenotype Ontology

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HPO ID	HPO Term
HP:0000007	Autosomal recessive inheritance
HP:0000012	Urinary urgency
HP:0000143	Rectovaginal fistula
HP:0000252	Microcephaly
HP:0000268	Dolichocephaly
HP:0000347	Micrognathia
HP:0000365	Hearing impairment
HP:0000453	Choanal atresia
HP:0000639	Nystagmus
HP:0000648	Optic atrophy

Displaying **all 5** entries
Disease ID	Disease Name
OMIM:619621	spastic paraplegia 84, autosomal recessive
ORPHA:98889	bilateral perisylvian polymicrogyria
OMIM:616531	polymicrogyria, perisylvian, with cerebellar hypoplasia and arthrogryposis
ORPHA:436252	gastrointestinal defects and immunodeficiency syndrome 1 multiple intestinal atresia
OMIM:619708	gastrointestinal defects and immunodeficiency syndrome 2

PubChem Disease

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001390
Gene Name: phosphatidylinositol 4-kinase, catalytic, alpha

Ortholog

Displaying entries **11 - 20** of 81 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Gadus morhua	115545109		GADMO52299
Oreochromis niloticus	100696465		ORENI10755
Sparus aurata	115593188		SPAAU32743
Xenopus laevis	446720	Xenbase:XB-GENE-980717
Xenopus laevis	108716048	Xenbase:XB-GENE-17332139
Xenopus tropicalis	100127709	Xenbase:XB-GENE-980714
Chrysemys picta bellii	101932464		CHRPI08162
Crocodylus porosus	109312796		CROPO18950
Meleagris gallopavo	100542492		MELGA04719
Serinus canaria	103818272		SERCA12859

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

PubChem Disease

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements