pyruvate kinase M1/2

Summary
Gene Symbol
  • PKM
Aliases
  • OIP3
  • PK3
  • THBP1
Organism
Homo sapiens (human)
External Links
NCBI Gene
5315
HGNC
9021
KEGG Gene ID
hsa:5315
PubChem
5315
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • ATP-binding
  • Acetylation
  • Allosteric enzyme
  • Alternative splicing
  • Cytoplasm
  • Direct protein sequencing
  • Glycolysis
  • Hydroxylation
  • Isopeptide bond
  • Kinase
  • Magnesium
  • Metal-binding
  • Methylation
  • Nucleus
  • Phosphoprotein
  • Potassium
  • Proteomics identification
  • Pyruvate
  • Reference proteome
  • S-nitrosylation
  • Translation regulation
  • Ubl conjugation
Proteins
Displaying all 5 entries
UniProt Protein Name
B4DNK4
V9HWB8
A0A804F6T5
A0A804F729
P14618
  • Cytosolic thyroid hormone-binding protein
  • Opa-interacting protein 3
  • Pyruvate kinase 2/3
  • Pyruvate kinase muscle isozyme
  • Threonine-protein kinase PKM2
  • Thyroid hormone-binding protein 1
  • Tumor M2-PK
  • Tyrosine-protein kinase PKM2
  • p58
Gene Ontology (GO)
Displaying entries 6 - 8 of 8 in total
GO Term Evidence Code PMID
glycolytic process
positive regulation of cytoplasmic translation
programmed cell death
GO Hierarchy
GO Hierarchy
Human Protein Atlas
ENSG00000067225

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

KEGG BRITE Database
Orthology
K00873
Name
pyruvate kinase [EC:2.7.1.40]
References
Disease
Disease Ontology
Displaying entries 1 - 10 of 219 in total
DO ID Disease Name Source
DOID:0014667 disease of metabolism
DOID:0040085 bacterial sepsis
DOID:0050387 nonpapillary renal cell carcinoma
DOID:0050589 inflammatory bowel disease
DOID:0050639 primary cutaneous amyloidosis
DOID:0050646 distal arthrogryposis
DOID:0050819 obsolete Matthew-Wood syndrome
DOID:0050865 tongue squamous cell carcinoma
DOID:0050902 medulloblastoma
DOID:0060061 primary cutaneous T-cell non-Hodgkin lymphoma

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024