phospholipase A2 group IVA

Summary
Gene Symbol
  • PLA2G4A
Aliases
  • cPLA2-alpha
Organism
Homo sapiens (human)
External Links
NCBI Gene
5321
HGNC
9035
KEGG Gene ID
hsa:5321
PubChem
5321
Alliance of Genome Resources
Annotation
Keyword
  • 3D-structure
  • Calcium
  • Cytoplasm
  • Direct protein sequencing
  • Disease variant
  • Glycerol metabolism
  • Golgi apparatus
  • Hydrolase
  • Isopeptide bond
  • Leukotriene biosynthesis
  • Lipid-binding
  • Membrane
  • Metal-binding
  • Nucleus
  • Phospholipid degradation
  • Phosphoprotein
  • Prostaglandin biosynthesis
  • Reference proteome
  • Ubl conjugation
Proteins
Displaying all 2 entries
UniProt Protein Name
P47712
  • Phospholipase A2 group IVA
B4DZI4
Gene Ontology (GO)
GO Hierarchy
Displaying entries 11 - 12 of 12 in total
GO Term Evidence Code PMID
lysophospholipase activity
ceramide 1-phosphate binding
Human Protein Atlas
ENSG00000116711

soft tissue soft tissue blood blood blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node kidney kidney adrenal gland adrenal gland breast breast duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland nasopharynx nasopharynx tongue tonsil tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder ductus deferens ductus deferens seminal vesicle seminal vesicle seminal vesicle seminal vesicle testis testis epididymis epididymis brain smooth muscle urinary bladder prostate bone marrow skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus cartilage sole of foot sole of foot soft tissue blood blood blood blood blood blood blood blood blood blood blood blood lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lymph node lactating breast lactating breast kidney kidney adrenal gland adrenal gland duodenum stomach small intestine colon rectum appendix esophagus eye eye salivary gland salivary gland salivary gland salivary gland salivary gland salivary gland nasopharynx tongue tonsil tonsil hair skin adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue adipose tissue spinal cord oral mucosa lung lung heart bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus bronchus liver pancreas thyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland parathyroid gland spleen gallbladder brain skeletal muscle skeletal muscle skeletal muscle skeletal muscle skeletal muscle thymus thymus smooth muscle urinary bladder vagina ovary ovary fallopian tube fallopian tube endometrium placenta cervix cervix bone marrow cartilage sole of foot sole of foot olfactory region cerebral cortex cerebellum medulla pons midbrain pituitary gland hypothalamus amygdala thalamus choroid plexus choroid plexus corpus callosum basal ganglia substantia nigra dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe dorsal raphe caudate hippocampus retina retina

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

KEGG BRITE Database
Orthology
K16342
Name
cytosolic phospholipase A2 [EC:3.1.1.4]
References
Disease
Disease Ontology
Displaying entries 91 - 100 of 224 in total
DO ID Disease Name Source
DOID:1790 malignant mesothelioma
DOID:1793 pancreatic cancer
DOID:1799 islet cell tumor
DOID:1824 status epilepticus
DOID:3904 bronchus carcinoma
DOID:1826 epilepsy
DOID:1909 melanoma
DOID:1936 atherosclerosis
DOID:1984 rectal benign neoplasm
DOID:1993 rectum cancer
The Human Phenotype Ontology
Displaying all 6 entries
HPO ID HPO Term
HP:0000007 Autosomal recessive inheritance
HP:0001891 Iron deficiency anemia
HP:0002588 Duodenal ulcer
HP:0002592 Gastric ulcer
HP:0003540 Impaired platelet aggregation
HP:0004791 Esophageal ulceration
Displaying 1 entry
Disease ID Disease Name
OMIM:618372
  • cytosolic phospholipase-A2 alpha deficiency associated bleeding disorder
LIPID MAPS Gene / Proteome Database
LMPD ID
LMP001081
Gene Name
phospholipase A2, group IVA (cytosolic, calcium-dependent)

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Acknowledgements

Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01


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Last updated: August 19, 2024