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Repository for lectin-assisted multimodality data

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Guidelines

MIRAGE

ectonucleotide pyrophosphatase/phosphodiesterase 2

Summary

Gene Symbol

ENPP2

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 532663
KEGG Gene ID: bta:532663
PubChem: 532663

Annotation

Keyword

Calcium
Chemotaxis
Cleavage on pair of basic residues
Direct protein sequencing
Disulfide bond
Glycoprotein
Hydrolase
Lipid degradation
Metal-binding
Obesity
Reference proteome
Repeat
Secreted
Signal
Zinc

Proteins

Displaying 1 entry
UniProt	Protein Name
A1A4K5	Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 Extracellular lysophospholipase D

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
chemotaxis
immune response	IEA	22301074
phospholipid catabolic process
sphingolipid catabolic process
phosphatidylcholine catabolic process	IEA	30032202

GO Hierarchy

biological process

immune system process [inference]

immune response

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

organonitrogen compound catabolic process [inference]

catabolic process [inference]

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organonitrogen compound catabolic process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organonitrogen compound metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid catabolic process

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

organonitrogen compound catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organonitrogen compound catabolic process [inference]

cellular process [inference]

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

organophosphate catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

cellular catabolic process [inference]

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

cellular lipid metabolic process [inference]

membrane lipid metabolic process [inference]

sphingolipid metabolic process [inference]

sphingolipid catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

phospholipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

phospholipid catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

cellular lipid catabolic process [inference]

phospholipid catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

membrane lipid catabolic process [inference]

sphingolipid catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylcholine metabolic process [inference]

phosphatidylcholine catabolic process

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

glycerolipid catabolic process [inference]

glycerophospholipid catabolic process [inference]

phosphatidylcholine catabolic process

reproductive process [inference]

multicellular organismal reproductive process [inference]

ovulation cycle [inference]

estrous cycle

locomotion [inference]

taxis [inference]

chemotaxis

rhythmic process [inference]

ovulation cycle [inference]

estrous cycle

response to stimulus [inference]

immune response

Displaying 1 entry
GO Term	Evidence Code	PMID
extracellular space	IEA	30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
nucleic acid binding	IEA	22301074
phosphodiesterase I activity	IEA	30032202
lysophospholipase activity	IEA	30032202
phospholipase D activity
scavenger receptor activity	IEA	22301074

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

exonuclease activity [inference]

phosphodiesterase I activity

lipase activity [inference]

phospholipase activity [inference]

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

carboxylic ester hydrolase activity [inference]

lysophospholipase activity

binding [inference]

carbohydrate binding [inference]

polysaccharide binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding

cargo receptor activity [inference]

scavenger receptor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

ectonucleotide pyrophosphatase/phosphodiesterase

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 2** entries
Gene Ontology
hydrolase activity
metal ion binding

Displaying **all 7** entries
InterPro
Alkaline-phosphatase-like, core domain superfamily
DNA/RNA non-specific endonuclease superfamily
DNA/RNA non-specific endonuclease
Extracellular Endonuclease, subunit A
His-Me finger superfamily
Somatomedin B domain
Type I phosphodiesterase/nucleotide pyrophosphatase/phosphate transferase

Rhea

H₂O + 1-O-alkyl-sn-glycero-3-phosphoethanolamine

H⁺ + ethanolamine + 1-O-alkyl-sn-glycero-3-phosphate

Enzyme

3.1.4.39

PMID

H₂O + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphoethanolamine

H⁺ + ethanolamine + 1-O-(1Z-alkenyl)-sn-glycero-3-phosphate

Enzyme

3.1.4.39

PMID

4855486

Ortholog

Displaying entries **21 - 30** of 73 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Pan paniscus	100968387		PANPA38796
Papio anubis	101004226		PAPAN39324
Saimiri boliviensis boliviensis	101050454		SAIBB21676
Felis catus	101097620		FELCA38521
Ovis aries	101120171		SHEEP19434
Gorilla gorilla gorilla	101136293		GORGO41290
Oryzias latipes	101171937		ORYLA05405
Tursiops truncatus	101317181		TURTR04162
Octodon degus	101578328		OCTDE22393
Jaculus jaculus	101606974		JACJA12952

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Last updated: December 8, 2025