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phospholipase C beta 2

Summary

Gene Symbol

PLCB2

Aliases

FLJ38135

Organism

Homo sapiens (human)

External Links

NCBI Gene

5330

HGNC

9055

KEGG Gene ID

hsa:5330

PubChem

5330

Alliance of Genome Resources

HGNC:9055

Annotation

Keyword

3D-structure
Alternative splicing
Calcium
Coiled coil
Hydrolase
Lipid degradation
Metal-binding
Phosphoprotein
Proteomics identification
Reference proteome
Transducer

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q59F77
Q00722	Phosphoinositide phospholipase C-beta-2 Phospholipase C-beta-2
Q9BVT6

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
detection of chemical stimulus involved in sensory perception of bitter taste	IEA
G protein-coupled receptor signaling pathway	IBA TAS
release of sequestered calcium ion into cytosol	IBA
phospholipase C-activating G protein-coupled receptor signaling pathway	ISS
activation of phospholipase C activity		7649993

GO Hierarchy

biological process

metabolic process [inference]

catabolic process [inference]

organic substance catabolic process [inference]

lipid catabolic process

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

primary metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organic substance metabolic process [inference]

lipid metabolic process [inference]

lipid catabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organic substance catabolic process [inference]

lipid catabolic process

cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

phosphatidylinositol-mediated signaling

cellular metabolic process [inference]

phosphorus metabolic process [inference]

phosphate-containing compound metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

organophosphate metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

cellular lipid metabolic process [inference]

phospholipid metabolic process

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

glycerolipid metabolic process [inference]

glycerophospholipid metabolic process [inference]

phosphatidylinositol metabolic process

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

response to stimulus [inference]

detection of stimulus [inference]

detection of chemical stimulus [inference]

detection of chemical stimulus involved in sensory perception [inference]

detection of chemical stimulus involved in sensory perception of taste [inference]

detection of chemical stimulus involved in sensory perception of bitter taste

detection of stimulus involved in sensory perception [inference]

detection of chemical stimulus involved in sensory perception [inference]

detection of chemical stimulus involved in sensory perception of taste [inference]

detection of chemical stimulus involved in sensory perception of bitter taste

localization [inference]

establishment of localization [inference]

transport [inference]

monoatomic ion transport [inference]

monoatomic cation transport [inference]

metal ion transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

transmembrane transport [inference]

monoatomic ion transmembrane transport [inference]

monoatomic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

inorganic ion transmembrane transport [inference]

inorganic cation transmembrane transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

organic substance transport [inference]

calcium ion transport [inference]

calcium ion transmembrane transport [inference]

calcium ion transmembrane import into cytosol [inference]

release of sequestered calcium ion into cytosol

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

negative regulation of biological process [inference]

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of cellular process [inference]

signal transduction [inference]

G protein-coupled receptor signaling pathway

phospholipase C-activating G protein-coupled receptor signaling pathway

intracellular signal transduction [inference]

phosphatidylinositol-mediated signaling

negative regulation of cellular process [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of sequestering of calcium ion [inference]

negative regulation of sequestering of calcium ion [inference]

release of sequestered calcium ion into cytosol

regulation of molecular function [inference]

positive regulation of molecular function [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of lipase activity [inference]

positive regulation of phospholipase activity [inference]

positive regulation of phospholipase C activity [inference]

activation of phospholipase C activity

regulation of catalytic activity [inference]

positive regulation of catalytic activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of lipase activity [inference]

positive regulation of phospholipase activity [inference]

positive regulation of phospholipase C activity [inference]

activation of phospholipase C activity

regulation of hydrolase activity [inference]

positive regulation of hydrolase activity [inference]

positive regulation of lipase activity [inference]

positive regulation of phospholipase activity [inference]

positive regulation of phospholipase C activity [inference]

activation of phospholipase C activity

regulation of lipase activity [inference]

regulation of phospholipase activity [inference]

positive regulation of phospholipase activity [inference]

positive regulation of phospholipase C activity [inference]

activation of phospholipase C activity

regulation of phospholipase C activity [inference]

positive regulation of phospholipase C activity [inference]

activation of phospholipase C activity

positive regulation of lipase activity [inference]

positive regulation of phospholipase activity [inference]

positive regulation of phospholipase C activity [inference]

activation of phospholipase C activity

Displaying **all 4** entries
GO Term	Evidence Code	PMID
cytosol
cytoplasm	IBA
neuronal dense core vesicle	IEA
G-protein beta/gamma-subunit complex	IEA

GO Hierarchy

cellular component

protein-containing complex [inference]

G-protein beta/gamma-subunit complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

dense core granule [inference]

neuronal dense core vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

dense core granule [inference]

neuronal dense core vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

secretory vesicle [inference]

secretory granule [inference]

dense core granule [inference]

neuronal dense core vesicle

Displaying entries **1 - 5** of 6 in total

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GO Term	Evidence Code	PMID
phospholipase C activity
G-protein beta/gamma-subunit complex binding	IEA
calcium ion binding	IEA
phospholipid binding	IEA
protein binding	IPI	21115837

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

lipase activity [inference]

phospholipase activity [inference]

phospholipase C activity

phosphatidylinositol phospholipase C activity

phosphoric ester hydrolase activity [inference]

phosphoric diester hydrolase activity [inference]

phospholipase C activity

phosphatidylinositol phospholipase C activity

binding [inference]

protein binding

lipid binding [inference]

phospholipid binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

calcium ion binding

protein-containing complex binding [inference]

G-protein beta/gamma-subunit complex binding

Gene Ontology information from NCBI Gene and UniProt.

Human Protein Atlas

ENSG00000137841

Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.

Data available from v23.0.proteinatlas.org. Image credit: Human Protein Atlas

KEGG BRITE Database

Orthology

K05858

Name

phosphatidylinositol phospholipase C, beta [EC:3.1.4.11]

References

Rhea

RHEA:33179

H₂O + a 1,2-diacyl-sn-glycero-3-phospho-(1D-myo-inositol-4,5-bisphosphate)

H⁺ + a 1,2-diacyl-sn-glycerol + 1D-myo-inositol 1,4,5-trisphosphate

Enzyme

3.1.4.11

PMID

Disease

Disease Ontology

Displaying entries **1 - 10** of 21 in total

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DO ID	Disease Name	Source
DOID:11847	coronary thrombosis	DisGeNET
DOID:1612	breast cancer	DisGeNET DisGeNET
DOID:162	cancer	DisGeNET DisGeNET DisGeNET
DOID:1682	congenital heart disease	Alliance of Genome Resources
DOID:1909	melanoma	DisGeNET
DOID:299	adenocarcinoma	DisGeNET
DOID:3008	invasive ductal carcinoma	DisGeNET
DOID:3459	breast carcinoma	DisGeNET
DOID:3571	liver cancer	DisGeNET
DOID:4766	embryoma	DisGeNET

LIPID MAPS Gene / Proteome Database

LMPD ID: LMP001097
Gene Name: phospholipase C, beta 2

Ortholog

Displaying entries **1 - 10** of 77 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	33204	FB:FBgn0004611
Danio rerio	569376	ZFIN:ZDB-GENE-080419-1
Ictalurus punctatus	108269611		ICTPU35214
Salmo salar	106610872		SALSA145235
Gadus morhua	115544368		GADMO49430
Poecilia reticulata	103458561		POERE19868
Oreochromis niloticus	100706825		ORENI32073
Haplochromis burtoni	102300157		HAPBU04055
Astatotilapia calliptera	113012617		ASTCA18605
Xenopus laevis	108699254	Xenbase:XB-GENE-17344771

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

KEGG BRITE Database

LIPID MAPS Gene / Proteome Database

International Collaboration

Acknowledgements