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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
phospholipase C beta 4
Summary
- Gene Symbol
-
- PLCB4
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- Acetylation
- Alternative splicing
- Calcium
- Cell membrane
- Coiled coil
- Direct protein sequencing
- Disease variant
- Hydrolase
- Lipid degradation
- Metal-binding
- Phosphoprotein
- Proteomics identification
- Reference proteome
- Transducer
- Proteins
| UniProt | Protein Name |
|---|---|
| A0A7P0MRI8 |
|
| Q15147 |
|
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| G protein-coupled receptor signaling pathway |
|
|
| release of sequestered calcium ion into cytosol | ||
| phosphatidylinositol metabolic process | ||
| phosphatidylinositol-mediated signaling | ||
| lipid catabolic process |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| cytosol |
|
|
| plasma membrane |
| GO Term | Evidence Code | PMID |
|---|---|---|
| phospholipase C activity |
|
|
| calcium ion binding | ||
| protein binding | ||
| phosphatidylinositol phospholipase C activity |
GO Hierarchy
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
KEGG BRITE Database
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0050540 | Charcot-Marie-Tooth disease type 3 | |
| DOID:0050742 | nicotine dependence | |
| DOID:0050848 | obstructive sleep apnea | |
| DOID:0050908 | myelodysplastic syndrome | |
| DOID:0060260 | ptosis | |
| DOID:6873 | skin tag | |
| DOID:0060261 | congenital ptosis | |
| DOID:0060600 | obsolete hereditary motor and sensory neuropathy with agenesis of the corpus callosum | |
| DOID:0060843 | hereditary neuropathy with liability to pressure palsies | |
| DOID:0070309 | absence epilepsy |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000006 | Autosomal dominant inheritance |
| HP:0000007 | Autosomal recessive inheritance |
| HP:0000160 | Narrow mouth |
| HP:0000162 | Glossoptosis |
| HP:0000171 | Microglossia |
| HP:0000175 | Cleft palate |
| HP:0000183 | Difficulty in tongue movements |
| HP:0000193 | Bifid uvula |
| HP:0000256 | Macrocephaly |
| HP:0000293 | Full cheeks |
| Disease ID | Disease Name |
|---|---|
| OMIM:614669 |
|
| ORPHA:137888 |
|
PubChem Disease
- GHR Health Conditions
- MedGen Diseases
- OMIM Phenotypes
- KEGG Diseases
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP000593
- Gene Name
- phospholipase C, beta 4
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 178537 | WB:WBGene00001177 | ||
| 31376 | FB:FBgn0262738 | ||
| 102682149 | LEPOC00681 | ||
| 407700 | ZFIN:ZDB-GENE-060627-1 | ||
| 103022380 | ASTMX16480 | ||
| 113589466 | ELEEL05915 | ||
| 105017521 | ESOLU53309 | ||
| 115172765 | SALTR24986 | ||
| 115174483 | SALTR53218 | ||
| 115534513 | GADMO32180 |
