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Genes / Proteins / Lipids Glycans / Glycoconjugates Glycomes Pathways / Interactions / Diseases / Organisms
phospholipase C gamma 1
Summary
- Gene Symbol
-
- PLCG1
- Aliases
-
- NCKAP3
- PLC-II
- PLC148
- PLCgamma1
- Organism
- Homo sapiens (human)
Annotation
- Keyword
-
- 3D-structure
- Acetylation
- Alternative splicing
- Calcium
- Cell projection
- Disease variant
- Host-virus interaction
- Hydrolase
- Lipid degradation
- Metal-binding
- Phosphoprotein
- Reference proteome
- Repeat
- SH2 domain
- SH3 domain
- Transducer
- Ubl conjugation
- Proteins
Gene Ontology (GO)
| GO Term | Evidence Code | PMID |
|---|---|---|
| cell migration | ||
| T cell receptor signaling pathway |
|
|
| release of sequestered calcium ion into cytosol | ||
| Fc-epsilon receptor signaling pathway |
|
|
| positive regulation of release of sequestered calcium ion into cytosol |
GO Hierarchy
biological process
metabolic process [inference]
cellular process [inference]
biological regulation [inference]
regulation of biological process [inference]
regulation of immune system process [inference]
regulation of localization [inference]
regulation of locomotion [inference]
positive regulation of biological process [inference]
regulation of response to stimulus [inference]
regulation of cellular process [inference]
| GO Term | Evidence Code | PMID |
|---|---|---|
| ruffle membrane | ||
| glutamatergic synapse | ||
| cytosol | ||
| cytoplasm | ||
| cell-cell junction |
GO Hierarchy
| GO Term | Evidence Code | PMID |
|---|---|---|
| guanyl-nucleotide exchange factor activity | ||
| calcium-dependent phospholipase C activity | ||
| glutamate receptor binding | ||
| phospholipase C activity | ||
| protein kinase binding |
Human Protein Atlas
Tissue with high expression from Human Protein Atlas. Tissues that are highly expressed are highlighted.
Rhea
Disease
- Disease Ontology
| DO ID | Disease Name | Source |
|---|---|---|
| DOID:0001816 | angiosarcoma | |
| DOID:0040085 | bacterial sepsis | |
| DOID:0050424 | familial adenomatous polyposis | |
| DOID:0050453 | lissencephaly | |
| DOID:0050523 | adult T-cell leukemia/lymphoma | |
| DOID:0050524 | maturity-onset diabetes of the young | |
| DOID:0050778 | Meckel syndrome | |
| DOID:0050865 | tongue squamous cell carcinoma | |
| DOID:0050866 | oral squamous cell carcinoma | |
| DOID:0050908 | myelodysplastic syndrome |
- The Human Phenotype Ontology
| HPO ID | HPO Term |
|---|---|
| HP:0000006 | Autosomal dominant inheritance |
| HP:0000225 | Gingival bleeding |
| HP:0000421 | Epistaxis |
| HP:0000967 | Petechiae |
| HP:0001903 | Anemia |
| HP:0003493 | Antinuclear antibody positivity |
| HP:0003565 | Elevated erythrocyte sedimentation rate |
| HP:0005421 | Decreased circulating complement C3 concentration |
| HP:0011463 | Childhood onset |
| Disease ID | Disease Name |
|---|---|
| OMIM:620514 |
|
PubChem Disease
- MedGen Diseases
- OMIM Phenotypes
LIPID MAPS Gene / Proteome Database
- LMPD ID
- LMP002259
- Gene Name
- phospholipase C, gamma 1
Ortholog
| Species | Gene ID | Alliance of Genome Resources | Orthologous MAtrix |
|---|---|---|---|
| 174586 | WB:WBGene00004038 | ||
| 32601 | FB:FBgn0003416 | ||
| 103186275 | CALMI34263 | ||
| 102362442 | LATCH19906 | ||
| 373867 | ZFIN:ZDB-GENE-030421-3 | ||
| 106566556 | SALSA29548 | ||
| 115168907 | SALTR75650 | ||
| 101163005 | ORYLA15843 | ||
| 100704581 | ORENI37524 | ||
| 115585070 | SPAAU52348 |
