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SHC adaptor protein 3

Summary

Gene Symbol

SHC3

Organism

Homo sapiens (human)

External Links

NCBI Gene

53358

PubChem

53358

Alliance of Genome Resources

HGNC:18181

Annotation

Keyword

Alternative splicing
Phosphoprotein
Reference proteome
SH2 domain

Proteins

Displaying 1 entry
UniProt	Protein Name
Q92529	Neuronal Shc Protein Rai SHC-transforming protein C Src homology 2 domain-containing-transforming protein C3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 4** entries
GO Term	Evidence Code	PMID
transmembrane receptor protein tyrosine kinase signaling pathway	IBA
epidermal growth factor receptor signaling pathway	TAS	8808684
central nervous system development	TAS	8808684
intracellular signal transduction	IEA

GO Hierarchy

biological process

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

intracellular signal transduction

developmental process [inference]

anatomical structure development [inference]

system development [inference]

central nervous system development

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

enzyme-linked receptor protein signaling pathway [inference]

transmembrane receptor protein tyrosine kinase signaling pathway

ERBB signaling pathway [inference]

epidermal growth factor receptor signaling pathway

intracellular signal transduction

Displaying **all 2** entries
GO Term	Evidence Code	PMID
cytosol	TAS
plasma membrane	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

cytosol

membrane [inference]

plasma membrane

Displaying **all 3** entries
GO Term	Evidence Code	PMID
phosphotyrosine residue binding	IPI	20624904
protein binding	IPI	11877420 16273093 24728074 25416956 32296183 32814053
receptor tyrosine kinase binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

signaling receptor binding [inference]

receptor tyrosine kinase binding

enzyme binding [inference]

kinase binding [inference]

protein kinase binding [inference]

protein tyrosine kinase binding [inference]

receptor tyrosine kinase binding

phosphoprotein binding [inference]

protein phosphorylated amino acid binding [inference]

phosphotyrosine residue binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

SHC-transforming protein

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
receptor tyrosine kinase binding
transmembrane receptor protein tyrosine kinase signaling pathway

Displaying **all 6** entries
InterPro
PH-like domain superfamily
PTB/PI domain
Phosphotyrosine interaction domain, Shc-like
SH2 adaptor protein C, SH2 domain
SH2 domain superfamily
SH2 domain

Ortholog

Displaying entries **1 - 10** of 62 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Drosophila melanogaster	6464	FB:FBgn0015296
Mus musculus	20418		MOUSE10898
Xenopus tropicalis	53358	Xenbase:XB-GENE-491820
Rattus norvegicus	114858		RATNO12720
Pan troglodytes	450176		PANTR44277
Macaca mulatta	574275		MACMU12086
Monodelphis domestica	100024603		MONDO29369
Equus caballus	100061926		HORSE22350
Taeniopygia guttata	100221851		TAEGU31806
Callithrix jacchus	100402406		CALJA19700