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nucleoporin 54

Summary

Gene Symbol

NUP54

Organism

Homo sapiens (human)

External Links

NCBI Gene

53371

PubChem

53371

Alliance of Genome Resources

HGNC:17359

Annotation

Keyword

3D-structure
Alternative splicing
Dystonia
Glycoprotein
Membrane
Nuclear pore complex
Reference proteome
Repeat

Proteins

Displaying 1 entry
UniProt	Protein Name
Q7Z3B4	54 kDa nucleoporin

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
protein targeting	IEA
NLS-bearing protein import into nucleus	IBA
nucleocytoplasmic transport	NAS	27016207
nuclear pore organization	IBA
protein localization to nuclear inner membrane	IBA

GO Hierarchy

biological process

cellular process [inference]

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport

import into nucleus [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to nuclear inner membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

protein localization to nuclear envelope [inference]

protein localization to nuclear inner membrane

establishment of protein localization to organelle [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

establishment of protein localization [inference]

protein targeting

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

protein localization to membrane [inference]

protein localization to nuclear inner membrane

cellular component organization or biogenesis [inference]

cellular component organization [inference]

organelle organization [inference]

nucleus organization [inference]

nuclear pore organization

protein-containing complex organization [inference]

nuclear pore organization

localization [inference]

macromolecule localization [inference]

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

protein localization to nuclear envelope [inference]

protein localization to nuclear inner membrane

establishment of protein localization to organelle [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

establishment of protein localization [inference]

protein targeting

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

protein localization to membrane [inference]

protein localization to nuclear inner membrane

establishment of localization [inference]

transport [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport

import into nucleus [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

organic substance transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

mRNA transport

nitrogen compound transport [inference]

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

nucleobase-containing compound transport [inference]

nucleic acid transport [inference]

RNA transport [inference]

mRNA transport

establishment of protein localization [inference]

protein targeting

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

establishment of RNA localization [inference]

RNA transport [inference]

mRNA transport

establishment of localization in cell [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport

import into nucleus [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

cellular localization [inference]

intracellular transport [inference]

intracellular protein transport [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

nuclear transport [inference]

nucleocytoplasmic transport

import into nucleus [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

localization within membrane [inference]

protein localization to membrane [inference]

protein localization to nuclear inner membrane

cellular macromolecule localization [inference]

protein localization [inference]

protein localization to organelle [inference]

protein localization to nucleus [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

protein localization to nuclear envelope [inference]

protein localization to nuclear inner membrane

establishment of protein localization to organelle [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

establishment of protein localization [inference]

protein targeting

protein transport [inference]

intracellular protein transport [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

establishment of protein localization to organelle [inference]

protein import into nucleus [inference]

NLS-bearing protein import into nucleus

protein localization to membrane [inference]

protein localization to nuclear inner membrane

biological regulation [inference]

regulation of biological process [inference]

regulation of localization [inference]

regulation of transport [inference]

regulation of intracellular transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus

regulation of protein localization to nucleus [inference]

regulation of protein import into nucleus

regulation of cellular process [inference]

regulation of cellular localization [inference]

regulation of intracellular transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus

regulation of nucleocytoplasmic transport [inference]

regulation of protein import into nucleus

regulation of protein localization [inference]

regulation of establishment of protein localization [inference]

regulation of protein transport [inference]

regulation of intracellular protein transport [inference]

regulation of protein import into nucleus

regulation of protein localization to nucleus [inference]

regulation of protein import into nucleus

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nuclear envelope	TAS
nuclear envelope	IDA	24315095
nuclear pore	NAS	24315095
nuclear membrane	IEA
nuclear pore central transport channel	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

cellular anatomical entity [inference]

membrane [inference]

organelle membrane [inference]

nuclear membrane

envelope [inference]

organelle envelope [inference]

nuclear envelope

Displaying **all 4** entries
GO Term	Evidence Code	PMID
protein binding	IPI	16189514 21516116 21994455 25416956 26496610 27194810 30021884 31413325 31515488 32296183 32353859 32814053 33060197 33961781 35271311 36217030
structural constituent of nuclear pore	IBA
identical protein binding	IEA
protein-containing complex binding	IEA

GO Hierarchy

molecular function

structural molecule activity [inference]

structural constituent of nuclear pore

binding [inference]

protein binding

identical protein binding

protein-containing complex binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

NUP54

Functional Category

J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 3** entries
Gene Ontology
NLS-bearing protein import into nucleus
nuclear pore organization
protein localization to nuclear inner membrane

Displaying **all 3** entries
InterPro
Nucleoporin Nup54, alpha-helical domain
Nucleoporin Nup54/Nup57/Nup44
Nup54, C-terminal interacting domain

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:0060956	dystonia 37, early-onset with striatal lesions	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 92 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	36360	Xenbase:XB-GENE-948035
Xenopus tropicalis	53371	Xenbase:XB-GENE-948035
Rattus norvegicus	53372		RATNO08573
Mus musculus	269113	Xenbase:XB-GENE-948035	MOUSE45782
Pan troglodytes	461240		PANTR33698
Bos taurus	506916		BOVIN31703
Macaca mulatta	700112		MACMU37663
Bos taurus	789388		BOVIN31703
Monodelphis domestica	100016708		MONDO25752
Equus caballus	100051138		HORSE31259