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procollagen-lysine,2-oxoglutarate 5-dioxygenase 1

Summary

Gene Symbol

PLOD1

Aliases

LH1
lysyl hydroxlase 1
procollagen lysyl hydroxylase 1

Organism

Homo sapiens (human)

External Links

NCBI Gene

5351

HGNC

9081

PubChem

5351

Alliance of Genome Resources

HGNC:9081

Annotation

Keyword

Alternative splicing
Dioxygenase
Direct protein sequencing
Disease variant
Ehlers-Danlos syndrome
Endoplasmic reticulum
Glycoprotein
Iron
Membrane
Metal-binding
Reference proteome
Signal
Vitamin C

Proteins

Displaying 1 entry
UniProt	Protein Name
Q02809	Lysyl hydroxylase 1

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 5** entries
GO Term	Evidence Code	PMID
epidermis development	IMP	8449506
collagen fibril organization	IBA
response to hypoxia	IEP	15174142
peptidyl-lysine hydroxylation	IDA ISS	10934207 8621606 9582318 9724729
protein O-linked glycosylation	IDA	10934207

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

primary metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

glycosylation [inference]

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

macromolecule modification [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

macromolecule glycosylation [inference]

protein glycosylation [inference]

protein O-linked glycosylation

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

protein modification process [inference]

protein glycosylation [inference]

protein O-linked glycosylation

protein hydroxylation [inference]

peptidyl-lysine hydroxylation

peptidyl-amino acid modification [inference]

peptidyl-lysine modification [inference]

peptidyl-lysine hydroxylation

cellular process [inference]

cellular component organization or biogenesis [inference]

cellular component organization [inference]

extracellular structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

external encapsulating structure organization [inference]

extracellular matrix organization [inference]

collagen fibril organization

supramolecular fiber organization [inference]

collagen fibril organization

developmental process [inference]

anatomical structure development [inference]

tissue development [inference]

epidermis development

response to stimulus [inference]

response to stress [inference]

response to hypoxia

response to abiotic stimulus [inference]

response to oxygen levels [inference]

response to decreased oxygen levels [inference]

response to hypoxia

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
catalytic complex	IEA
Golgi apparatus	IBA
collagen-containing extracellular matrix	IBA
endoplasmic reticulum membrane	TAS
endoplasmic reticulum	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

catalytic complex

cellular anatomical entity [inference]

extracellular space

membrane [inference]

organelle membrane [inference]

endoplasmic reticulum membrane

rough endoplasmic reticulum membrane

bounding membrane of organelle [inference]

rough endoplasmic reticulum membrane

external encapsulating structure [inference]

extracellular matrix [inference]

collagen-containing extracellular matrix

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular membrane-bounded organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

extracellular organelle [inference]

extracellular membrane-bounded organelle [inference]

extracellular vesicle [inference]

extracellular exosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
protein binding	IPI	26496610 28514442 33961781
procollagen-lysine 5-dioxygenase activity	IBA IDA IMP ISS	10934207 8621606 9582318 9724729
procollagen glucosyltransferase activity	IDA	10934207
iron ion binding	IEA
L-ascorbic acid binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

oxidoreductase activity [inference]

oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-lysine 5-dioxygenase activity [inference]

procollagen-lysine 5-dioxygenase activity

dioxygenase activity [inference]

2-oxoglutarate-dependent dioxygenase activity [inference]

peptidyl-lysine 5-dioxygenase activity [inference]

procollagen-lysine 5-dioxygenase activity

transferase activity [inference]

glycosyltransferase activity [inference]

hexosyltransferase activity [inference]

glucosyltransferase activity [inference]

procollagen glucosyltransferase activity

catalytic activity, acting on a protein [inference]

procollagen glucosyltransferase activity

peptidyl-lysine 5-dioxygenase activity [inference]

procollagen-lysine 5-dioxygenase activity

binding [inference]

protein binding

carbohydrate binding [inference]

monosaccharide binding [inference]

L-ascorbic acid binding

small molecule binding [inference]

vitamin binding [inference]

L-ascorbic acid binding

organic acid binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

monosaccharide binding [inference]

L-ascorbic acid binding

heterocyclic compound binding [inference]

L-ascorbic acid binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

L-ascorbic acid binding

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

iron ion binding

organic cyclic compound binding [inference]

L-ascorbic acid binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

procollagen-lysine 2-oxoglutarate 5-dioxygenase 2

Functional Category

E: Amino acid transport and metabolism
J: Translation, ribosomal structure and biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 7** entries
Gene Ontology
L-ascorbic acid binding
dioxygenase activity
iron ion binding
metal ion binding
oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen
oxidoreductase activity
procollagen-proline 4-dioxygenase activity

Displaying **all 4** entries
InterPro
Oxoglutarate/iron-dependent dioxygenase
Prolyl 4-hydroxylase alpha subunit, Fe(2+) 2OG dioxygenase domain
Prolyl 4-hydroxylase, alpha subunit
Prolyl 4-hydroxylase

Disease

Disease Ontology

Displaying **all 4** entries
DO ID	Disease Name	Source
DOID:0080734	Ehlers-Danlos syndrome kyphoscoliotic type 1	Glyco-Disease Genes Database Alliance of Genome Resources
DOID:13359	Ehlers-Danlos syndrome	Alliance of Genome Resources
DOID:1459	hypothyroidism	Alliance of Genome Resources
DOID:14775	brittle cornea syndrome 1	Glyco-Disease Genes Database

Ortholog

Displaying entries **71 - 78** of 78 in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Strigops habroptila	115617272		STRHB16407
Chelonoidis abingdonii	116821905		CHEAB01704
Rhinolophus ferrumequinum	117027502		RHIFE03364
Balaenoptera musculus	118902717		BALMU22154
Callorhinchus milii	121850705		CALMI22689
Panthera leo	122226860		PANLE09669
Ursus americanus	123779622		URSAM26417
Pongo pygmaeus	129007659	9600_0:00001b

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements