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nth like DNA glycosylase 1

Summary

Gene Symbol

NTHL1

Organism

Bos taurus (domestic cattle)

External Links

NCBI Gene: 535203
PubChem: 535203

Annotation

Keyword

4Fe-4S
DNA repair
Glycosidase
Lyase
Mitochondrion
Nucleus
Phosphoprotein
Reference proteome
Transit peptide

Proteins

Displaying 1 entry
UniProt	Protein Name
Q2KID2	Bifunctional DNA N-glycosylase/DNA-(apurinic or apyrimidinic site) lyase

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
base-excision repair	IEA	22301074
base-excision repair, AP site formation	IEA	22301074 30032202
nucleotide-excision repair	IEA	30032202

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA repair [inference]

base-excision repair, AP site formation

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

Displaying **all 2** entries
GO Term	Evidence Code	PMID
mitochondrion
nucleus	IEA	22301074 30032202

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

Displaying entries **6 - 8** of 8 in total

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GO Term	Evidence Code	PMID
DNA-(apurinic or apyrimidinic site) endonuclease activity	IEA	22301074 30032202
oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity	IEA	30032202
damaged DNA binding

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on glycosyl bonds [inference]

hydrolase activity, hydrolyzing N-glycosyl compounds [inference]

DNA N-glycosylase activity [inference]

oxidized base lesion DNA N-glycosylase activity [inference]

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

lyase activity [inference]

carbon-oxygen lyase activity [inference]

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA-(apurinic or apyrimidinic site) endonuclease activity

class I DNA-(apurinic or apyrimidinic site) endonuclease activity

DNA N-glycosylase activity [inference]

oxidized base lesion DNA N-glycosylase activity [inference]

oxidized pyrimidine nucleobase lesion DNA N-glycosylase activity

binding [inference]

ion binding [inference]

cation binding [inference]

metal ion binding

metal cluster binding [inference]

iron-sulfur cluster binding [inference]

4 iron, 4 sulfur cluster binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

endonuclease

Functional Category

K: Transcription
L: Replication, recombination and repair
T: Signal transduction mechanisms

Displaying **all 8** entries
Gene Ontology
DNA repair
DNA-(apurinic or apyrimidinic site) endonuclease activity
base-excision repair, AP site formation
base-excision repair
catalytic activity
hydrolase activity, acting on glycosyl bonds
hydrolase activity
lyase activity

Displaying **all 6** entries
InterPro
DNA glycosylase
Endonuclease III-like protein 1
Endonuclease III-like, conserved site-2
Helix-hairpin-helix motif
Helix-hairpin-helix, base-excision DNA repair, C-terminal
HhH-GPD domain

Ortholog

Displaying entries **31 - 40** of 86 in total

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Last »
Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Chinchilla lanigera	102005847			CHILA11492
Capra hircus	102170376	9925_0:004468		CAPHI16535
Bos mutus	102267636	72004_1:00008d
Latimeria chalumnae	102359521			LATCH05983
Bubalus bubalis	102390962	89462_0:004f02
Myotis lucifugus	102422413			MYOLU13163
Pelodiscus sinensis	102448269			PELSI08006
Camelus ferus	102510406	419612_0:003576
Vicugna pacos	102524675	30538_0:002483
Lepisosteus oculatus	102698907			LEPOC03661

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Last updated: August 19, 2024