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Guidelines

MIRAGE

eosinophil-associated, ribonuclease A family, member 4

Summary

Gene Symbol

Ear4

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

53877

PubChem

53877

Alliance of Genome Resources

MGI:1858238

Annotation

Keyword

Disulfide bond
Endonuclease
Glycoprotein
Lyase
Lysosome
Nitration
Reference proteome
Signal

Proteins

Displaying 1 entry
UniProt	Protein Name
O35291	Eosinophil cationic-type ribonuclease 4 MR-4 Ribonuclease 2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
chemotaxis	IBA
innate immune response in mucosa	IBA
defense response to Gram-positive bacterium	IBA

GO Hierarchy

biological process

immune system process [inference]

immune response [inference]

organ or tissue specific immune response [inference]

mucosal immune response [inference]

innate immune response in mucosa

innate immune response [inference]

innate immune response in mucosa

locomotion [inference]

taxis [inference]

chemotaxis

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

innate immune response [inference]

innate immune response in mucosa

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

innate immune response [inference]

innate immune response in mucosa

immune response [inference]

organ or tissue specific immune response [inference]

mucosal immune response [inference]

innate immune response in mucosa

innate immune response [inference]

innate immune response in mucosa

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

innate immune response [inference]

innate immune response in mucosa

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

defense response to other organism [inference]

defense response to bacterium [inference]

defense response to Gram-positive bacterium

innate immune response [inference]

innate immune response in mucosa

Displaying **all 2** entries
GO Term	Evidence Code	PMID
lysosome	IEA
extracellular space	IBA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

vacuole [inference]

lytic vacuole [inference]

lysosome

Displaying **all 5** entries
GO Term	Evidence Code	PMID
nucleic acid binding	IEA
lyase activity	IEA
RNA nuclease activity	IBA ISO
ribonuclease A activity	IEA
lipopolysaccharide binding	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

endonuclease activity [inference]

RNA endonuclease activity [inference]

RNA endonuclease activity, producing 3'-phosphomonoesters [inference]

ribonuclease A activity

endonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 3'-phosphomonoesters [inference]

RNA endonuclease activity, producing 3'-phosphomonoesters [inference]

ribonuclease A activity

RNA nuclease activity

RNA endonuclease activity [inference]

RNA endonuclease activity, producing 3'-phosphomonoesters [inference]

ribonuclease A activity

lyase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

RNA nuclease activity

RNA endonuclease activity [inference]

RNA endonuclease activity, producing 3'-phosphomonoesters [inference]

ribonuclease A activity

binding [inference]

lipid binding [inference]

lipopolysaccharide binding

organic cyclic compound binding [inference]

nucleic acid binding

carbohydrate derivative binding [inference]

lipopolysaccharide binding

Gene Ontology information from NCBI Gene and UniProt.

Ortholog

Displaying entries **11 - 20** of 34 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Macaca mulatta	100425327			MACMU40568
Cricetulus griseus	100689288			CRIGR25635
Cricetulus griseus	100689289			CRIGR26752
Cricetulus griseus	100689290			CRIGR26752
Cricetulus griseus	100689291			CRIGR18986
Otolemur garnettii	100950392			OTOGA00783
Pan paniscus	100981889			PANPA11487
Ovis aries	101112062			SHEEP17973
Gorilla gorilla gorilla	101147304			GORGO08200
Gorilla gorilla gorilla	101147913			GORGO07750

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GlyCosmos is a member of the GlySpace Alliance together with GlyGen and Glycomics@ExPASy.

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Supported by JST NBDC Grant Number JPMJND2204

Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 9, 2024