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Guidelines

MIRAGE

inducible T cell co-stimulator

Summary

Gene Symbol

Icos

Organism

Mus musculus (house mouse)

External Links

NCBI Gene

54167

PubChem

54167

Alliance of Genome Resources

MGI:1858745

Annotation

Keyword

Disulfide bond
Glycoprotein
Immunoglobulin domain
Reference proteome
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q9WVS0	Activation-inducible lymphocyte immunomediatory molecule CD28 and CTLA-4-like protein CD28-related protein 1
Q5SUZ7
Q3V3X2

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
T cell tolerance induction	ISO
T cell tolerance induction	IBA
T cell costimulation	ISO
T cell costimulation	IBA
T cell costimulation	IEA

GO Hierarchy

biological process

immune system process [inference]

tolerance induction [inference]

T cell tolerance induction

lymphocyte costimulation [inference]

T cell costimulation

cellular process [inference]

cell adhesion [inference]

cell-cell adhesion

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of cellular process [inference]

regulation of cell adhesion [inference]

regulation of cell-cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

regulation of leukocyte cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cellular process [inference]

positive regulation of cell adhesion [inference]

positive regulation of cell-cell adhesion [inference]

positive regulation of leukocyte cell-cell adhesion [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of multicellular organismal process [inference]

regulation of cell activation [inference]

regulation of leukocyte activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

regulation of lymphocyte activation [inference]

regulation of T cell activation [inference]

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

positive regulation of multicellular organismal process [inference]

positive regulation of cell activation [inference]

positive regulation of leukocyte activation [inference]

positive regulation of lymphocyte activation [inference]

lymphocyte costimulation [inference]

T cell costimulation

positive regulation of T cell activation [inference]

T cell costimulation

Displaying **all 2** entries
GO Term	Evidence Code	PMID
plasma membrane	IDA	10760791
external side of plasma membrane	IDA	10760791 16227984 19008373 23583643

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

side of membrane [inference]

external side of plasma membrane

Displaying 1 entry
GO Term	Evidence Code	PMID
protein binding	IPI	10657606 10760791 27135603

GO Hierarchy

molecular function

binding [inference]

protein binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

Inducible T-cell costimulator

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 2** entries
Gene Ontology
T cell costimulation
T cell tolerance induction

Displaying **all 3** entries
InterPro
Immunoglobulin V-set domain
Immunoglobulin-like fold
Inducible T-cell costimulator

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:12177	common variable immunodeficiency	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 57 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	29851	HGNC:5351	HUMAN66529
Homo sapiens	54167	HGNC:5351
Rattus norvegicus	64545	HGNC:5351	RATNO43464
Canis lupus familiaris	403456		CANLF14145
Bos taurus	507026		BOVIN24620
Macaca mulatta	705788		MACMU06893
Sus scrofa	733597		PIGXX09848
Pan troglodytes	747295		PANTR29585
Equus caballus	100067953		HORSE13806
Taeniopygia guttata	100232284		TAEGU28573

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Last updated: April 7, 2025