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triggering receptor expressed on myeloid cells 1

Summary

Gene Symbol

TREM1

Organism

Homo sapiens (human)

External Links

NCBI Gene

54210

PubChem

54210

Alliance of Genome Resources

HGNC:17760

Annotation

Keyword

3D-structure
Adaptive immunity
Alternative splicing
Cell membrane
Disulfide bond
Glycoprotein
Immunoglobulin domain
Innate immunity
Proteomics identification
Receptor
Reference proteome
Secreted
Signal
Transmembrane helix

Proteins

Displaying **all 3** entries
UniProt	Protein Name
Q9NP99	Triggering receptor expressed on monocytes 1
K7EKM5
Q38L15

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
cytokine production involved in immune response	IBA
neutrophil chemotaxis	IBA
adaptive immune response	IEA
innate immune response	IEA
neutrophil-mediated killing of gram-negative bacterium	IBA

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

leukocyte mediated immunity [inference]

leukocyte mediated cytotoxicity [inference]

neutrophil mediated cytotoxicity [inference]

neutrophil-mediated killing of symbiont cell [inference]

neutrophil-mediated killing of bacterium [inference]

neutrophil-mediated killing of gram-negative bacterium

myeloid leukocyte mediated immunity [inference]

neutrophil mediated immunity [inference]

neutrophil mediated cytotoxicity [inference]

neutrophil-mediated killing of symbiont cell [inference]

neutrophil-mediated killing of bacterium [inference]

neutrophil-mediated killing of gram-negative bacterium

production of molecular mediator of immune response [inference]

cytokine production involved in immune response

immune response [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

metabolic process [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

cytokine production involved in immune response

production of molecular mediator of immune response [inference]

cytokine production involved in immune response

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

cytokine production involved in immune response

production of molecular mediator of immune response [inference]

cytokine production involved in immune response

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

cytokine production involved in immune response

production of molecular mediator of immune response [inference]

cytokine production involved in immune response

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

cytokine production involved in immune response

production of molecular mediator of immune response [inference]

cytokine production involved in immune response

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

cytokine production involved in immune response

production of molecular mediator of immune response [inference]

cytokine production involved in immune response

cellular process [inference]

cell killing [inference]

leukocyte mediated cytotoxicity [inference]

neutrophil mediated cytotoxicity [inference]

neutrophil-mediated killing of symbiont cell [inference]

neutrophil-mediated killing of bacterium [inference]

neutrophil-mediated killing of gram-negative bacterium

killing of cells of another organism [inference]

killing by host of symbiont cells [inference]

neutrophil-mediated killing of symbiont cell [inference]

neutrophil-mediated killing of bacterium [inference]

neutrophil-mediated killing of gram-negative bacterium

signal transduction [inference]

intracellular signal transduction

cellular metabolic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

gene expression [inference]

cytokine production [inference]

cytokine production involved in immune response

production of molecular mediator of immune response [inference]

cytokine production involved in immune response

cell motility [inference]

cell migration [inference]

leukocyte migration [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

myeloid leukocyte migration [inference]

granulocyte migration [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

neutrophil migration [inference]

neutrophil chemotaxis

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

multicellular organismal process [inference]

cytokine production [inference]

cytokine production involved in immune response

locomotion [inference]

taxis [inference]

chemotaxis [inference]

cell chemotaxis [inference]

leukocyte chemotaxis [inference]

granulocyte chemotaxis [inference]

neutrophil chemotaxis

biological process involved in interspecies interaction between organisms [inference]

biological process involved in symbiotic interaction [inference]

biological process involved in interaction with symbiont [inference]

killing by host of symbiont cells [inference]

neutrophil-mediated killing of symbiont cell [inference]

neutrophil-mediated killing of bacterium [inference]

neutrophil-mediated killing of gram-negative bacterium

response to other organism [inference]

defense response to other organism [inference]

innate immune response

killing by host of symbiont cells [inference]

neutrophil-mediated killing of symbiont cell [inference]

neutrophil-mediated killing of bacterium [inference]

neutrophil-mediated killing of gram-negative bacterium

disruption of anatomical structure in another organism [inference]

disruption of cell in another organism [inference]

killing of cells of another organism [inference]

killing by host of symbiont cells [inference]

neutrophil-mediated killing of symbiont cell [inference]

neutrophil-mediated killing of bacterium [inference]

neutrophil-mediated killing of gram-negative bacterium

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response

killing by host of symbiont cells [inference]

neutrophil-mediated killing of symbiont cell [inference]

neutrophil-mediated killing of bacterium [inference]

neutrophil-mediated killing of gram-negative bacterium

immune response [inference]

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

killing by host of symbiont cells [inference]

neutrophil-mediated killing of symbiont cell [inference]

neutrophil-mediated killing of bacterium [inference]

neutrophil-mediated killing of gram-negative bacterium

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

defense response to other organism [inference]

innate immune response

killing by host of symbiont cells [inference]

neutrophil-mediated killing of symbiont cell [inference]

neutrophil-mediated killing of bacterium [inference]

neutrophil-mediated killing of gram-negative bacterium

biological regulation [inference]

regulation of biological process [inference]

regulation of cellular process [inference]

signal transduction [inference]

intracellular signal transduction

Displaying **all 4** entries
GO Term	Evidence Code	PMID
plasma membrane	TAS
extracellular region	IEA
cell surface	IBA IDA	17098818
extracellular space	IDA	26561551

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

Displaying **all 4** entries
GO Term	Evidence Code	PMID
receptor decoy activity	IDA	26561551
signaling receptor activity	TAS	10799849
scaffold protein binding	IPI	11602640
transmembrane signaling receptor activity	IBA IDA	17098818

GO Hierarchy

molecular function

binding [inference]

protein binding [inference]

scaffold protein binding

molecular transducer activity [inference]

signaling receptor activity

transmembrane signaling receptor activity

molecular sequestering activity [inference]

receptor decoy activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

CMRF35-like molecule

Functional Category

G: Carbohydrate transport and metabolism
M: Cell wall/membrane/envelope biogenesis
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 3** entries
InterPro
Immunoglobulin V-set domain
Immunoglobulin-like domain superfamily
Immunoglobulin-like fold

Disease

Disease Ontology

Displaying entries **1 - 10** of 22 in total

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DO ID	Disease Name	Source
DOID:0040085	bacterial sepsis	Alliance of Genome Resources
DOID:0050697	chorioamnionitis	Alliance of Genome Resources
DOID:12365	malaria	Alliance of Genome Resources
DOID:13252	mesenteric vascular occlusion	Alliance of Genome Resources
DOID:14115	toxic shock syndrome	Alliance of Genome Resources
DOID:1596	depressive disorder	Alliance of Genome Resources
DOID:1883	hepatitis C	Alliance of Genome Resources
DOID:2043	hepatitis B	Alliance of Genome Resources
DOID:2913	acute pancreatitis	Alliance of Genome Resources
DOID:2957	pulmonary tuberculosis	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 37 in total

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Species	Gene ID	OrthoDB	Alliance of Genome Resources	Orthologous MAtrix
Mus musculus	58217		MGI:1930005	MOUSE19730
Rattus norvegicus	301229		RGD:1309467	RATNO43257
Sus scrofa	396601			PIGXX31536
Canis lupus familiaris	608994			CANLF02731
Macaca mulatta	693558			MACMU34756
Pongo abelii	100174314	9601_0:001d94		PONAB30668
Callithrix jacchus	100395436			CALJA32259
Nomascus leucogenys	100587513			NOMLE12267
Pan paniscus	100977244	9597_0:001b54
Papio anubis	100998592			PAPAN34202