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complement factor D

Summary

Gene Symbol

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

54249

PubChem

54249

Alliance of Genome Resources

RGD:2498

Annotation

Keyword

Complement alternate pathway
Direct protein sequencing
Disulfide bond
Glycoprotein
Reference proteome
Secreted
Serine protease
Signal
Zymogen

Proteins

Displaying 1 entry
UniProt	Protein Name
P32038	Adipsin C3 convertase activator Endogenous vascular elastase Properdin factor D

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
proteolysis	IEA
complement activation, alternative pathway	ISO
complement activation, alternative pathway	IEA
Notch signaling pathway	IMP	12949072
response to bacterium	ISO

GO Hierarchy

biological process

immune system process [inference]

immune effector process [inference]

complement activation [inference]

complement activation, alternative pathway

activation of immune response [inference]

complement activation [inference]

complement activation, alternative pathway

immune response [inference]

humoral immune response [inference]

complement activation [inference]

complement activation, alternative pathway

innate immune response [inference]

complement activation, alternative pathway

metabolic process [inference]

nitrogen compound metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

primary metabolic process [inference]

protein metabolic process [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

organonitrogen compound metabolic process [inference]

protein metabolic process [inference]

cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

cellular developmental process [inference]

cell differentiation [inference]

muscle cell differentiation [inference]

smooth muscle cell differentiation [inference]

vascular associated smooth muscle cell differentiation

developmental process [inference]

anatomical structure development [inference]

retina development in camera-type eye

cellular developmental process [inference]

cell differentiation [inference]

muscle cell differentiation [inference]

smooth muscle cell differentiation [inference]

vascular associated smooth muscle cell differentiation

biological process involved in interspecies interaction between organisms [inference]

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

response to stimulus [inference]

response to stress [inference]

defense response [inference]

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

immune response [inference]

humoral immune response [inference]

complement activation [inference]

complement activation, alternative pathway

innate immune response [inference]

complement activation, alternative pathway

response to external stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

response to biotic stimulus [inference]

response to external biotic stimulus [inference]

response to other organism [inference]

response to bacterium

defense response to other organism [inference]

innate immune response [inference]

complement activation, alternative pathway

biological regulation [inference]

regulation of biological process [inference]

regulation of immune system process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, alternative pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, alternative pathway

positive regulation of biological process [inference]

positive regulation of immune system process [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, alternative pathway

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, alternative pathway

regulation of response to stimulus [inference]

positive regulation of response to stimulus [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, alternative pathway

regulation of immune response [inference]

positive regulation of immune response [inference]

activation of immune response [inference]

complement activation [inference]

complement activation, alternative pathway

regulation of cellular process [inference]

signal transduction [inference]

cell surface receptor signaling pathway [inference]

Notch signaling pathway

Displaying **all 4** entries
GO Term	Evidence Code	PMID
extracellular space	ISO
extracellular space	IDA	2197880
extracellular space	IBA
extracellular space	IEA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

extracellular space

Displaying **all 4** entries
GO Term	Evidence Code	PMID
endopeptidase activity	IDA	1953671
serine-type endopeptidase activity	TAS	12949072
serine-type endopeptidase activity	IBA
serine-type endopeptidase activity	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity [inference]

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity [inference]

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity [inference]

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity [inference]

serine-type endopeptidase activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

serine protease

Functional Category

E: Amino acid transport and metabolism
O: Posttranslational modification, protein turnover, chaperones
Q: Secondary metabolites biosynthesis, transport and catabolism

Displaying **all 2** entries
Gene Ontology
proteolysis
serine-type endopeptidase activity

Displaying **all 5** entries
InterPro
Peptidase S1, PA clan, chymotrypsin-like fold
Peptidase S1, PA clan
Peptidase S1A, chymotrypsin family
Serine proteases, trypsin domain
Serine proteases, trypsin family, histidine active site

Alliance of Genome Resources

Expression

Displaying 1 entry
Location	References
extracellular space	PMID:2197880

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:1556	arthus reaction	Alliance of Genome Resources

Ortholog

Displaying entries **1 - 10** of 42 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Homo sapiens	1675		HUMAN39250
Mus musculus	11537	Xenbase:XB-GENE-973605	MOUSE02658
Xenopus tropicalis	54249	Xenbase:XB-GENE-973605
Xenopus tropicalis	394945	Xenbase:XB-GENE-973605
Sus scrofa	396877		PIGXX19019
Pan troglodytes	455533		PANTR16593
Canis lupus familiaris	485095		CANLF08120
Xenopus tropicalis	494791	Xenbase:XB-GENE-973605
Bos taurus	505647		BOVIN33359
Ornithorhynchus anatinus	791100		ORNAN28574

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements