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Annotation

Keyword

3D-structure
4Fe-4S
DNA repair
DNA replication
DNA-binding
DNA-directed DNA polymerase
Direct protein sequencing
Disease variant
Hydrolase
Nucleus
Phosphoprotein
Reference proteome
Zinc-finger

Proteins

Displaying 1 entry
UniProt	Protein Name
Q07864	3'-5' exodeoxyribonuclease DNA polymerase II subunit A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 12 in total

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GO Term	Evidence Code	PMID
G1/S transition of mitotic cell cycle	IMP	16762037
mitotic cell cycle	IBA
DNA synthesis involved in DNA repair	IMP	1730053
DNA replication	IMP	16762037
DNA-templated DNA replication	IDA	33051204

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair [inference]

DNA replication proofreading

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

leading strand elongation

DNA-templated DNA replication maintenance of fidelity [inference]

DNA replication proofreading

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair [inference]

DNA replication proofreading

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

leading strand elongation

DNA-templated DNA replication maintenance of fidelity [inference]

DNA replication proofreading

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair [inference]

DNA replication proofreading

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

leading strand elongation

DNA-templated DNA replication maintenance of fidelity [inference]

DNA replication proofreading

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair [inference]

DNA replication proofreading

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

leading strand elongation

DNA-templated DNA replication maintenance of fidelity [inference]

DNA replication proofreading

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair [inference]

DNA replication proofreading

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

leading strand elongation

DNA-templated DNA replication maintenance of fidelity [inference]

DNA replication proofreading

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair [inference]

DNA replication proofreading

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

leading strand elongation

DNA-templated DNA replication maintenance of fidelity [inference]

DNA replication proofreading

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair [inference]

DNA replication proofreading

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

leading strand elongation

DNA-templated DNA replication maintenance of fidelity [inference]

DNA replication proofreading

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

cellular process [inference]

cell cycle [inference]

mitotic cell cycle

cell cycle process [inference]

cell cycle phase transition [inference]

mitotic cell cycle phase transition [inference]

G1/S transition of mitotic cell cycle

cell cycle G1/S phase transition [inference]

G1/S transition of mitotic cell cycle

mitotic cell cycle process [inference]

mitotic cell cycle phase transition [inference]

G1/S transition of mitotic cell cycle

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair [inference]

DNA replication proofreading

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

leading strand elongation

DNA-templated DNA replication maintenance of fidelity [inference]

DNA replication proofreading

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair [inference]

DNA replication proofreading

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

leading strand elongation

DNA-templated DNA replication maintenance of fidelity [inference]

DNA replication proofreading

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

DNA-templated DNA replication

DNA repair [inference]

DNA replication proofreading

DNA strand elongation [inference]

DNA strand elongation involved in DNA replication [inference]

leading strand elongation

DNA-templated DNA replication maintenance of fidelity [inference]

DNA replication proofreading

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

DNA replication proofreading

developmental process [inference]

anatomical structure development [inference]

animal organ development [inference]

embryonic organ development

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

DNA replication proofreading

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

DNA repair [inference]

DNA replication proofreading

Displaying entries **1 - 5** of 7 in total

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GO Term	Evidence Code	PMID
nucleus	IDA	16762037
nucleoplasm	TAS
nucleoplasm	IDA
plasma membrane	IDA
epsilon DNA polymerase complex	IDA	10801849 22465957

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

epsilon DNA polymerase complex

intracellular protein-containing complex [inference]

DNA polymerase complex [inference]

epsilon DNA polymerase complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

DNA polymerase complex [inference]

epsilon DNA polymerase complex

cellular anatomical entity [inference]

nucleoplasm

membrane [inference]

plasma membrane

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

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GO Term	Evidence Code	PMID
nucleotide binding	IEA
DNA binding	IDA	16762037
DNA binding	IBA
chromatin binding	IDA	16762037
DNA-directed DNA polymerase activity	IMP	16762037

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

DNA polymerase activity [inference]

DNA-directed DNA polymerase activity

hydrolase activity [inference]

hydrolase activity, acting on ester bonds [inference]

nuclease activity [inference]

exonuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-DNA exonuclease activity [inference]

single-stranded DNA 3'-5' DNA exonuclease activity

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 3'-5' DNA exonuclease activity

3'-5' exonuclease activity [inference]

3'-5'-DNA exonuclease activity [inference]

single-stranded DNA 3'-5' DNA exonuclease activity

exonuclease activity, active with either ribo- or deoxyribonucleic acids and producing 5'-phosphomonoesters [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-DNA exonuclease activity [inference]

single-stranded DNA 3'-5' DNA exonuclease activity

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 3'-5' DNA exonuclease activity

DNA nuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-DNA exonuclease activity [inference]

single-stranded DNA 3'-5' DNA exonuclease activity

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 3'-5' DNA exonuclease activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA nuclease activity [inference]

DNA exonuclease activity [inference]

DNA exonuclease activity, producing 5'-phosphomonoesters [inference]

3'-5'-DNA exonuclease activity [inference]

single-stranded DNA 3'-5' DNA exonuclease activity

single-stranded DNA exodeoxyribonuclease activity [inference]

single-stranded DNA 3'-5' DNA exonuclease activity

DNA polymerase activity [inference]

DNA-directed DNA polymerase activity

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding

ion binding [inference]

cation binding [inference]

metal ion binding [inference]

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding [inference]

chromatin binding

metal cluster binding [inference]

iron-sulfur cluster binding [inference]

4 iron, 4 sulfur cluster binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding

nucleoside phosphate binding [inference]

nucleotide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DNA polymerase

Functional Category

L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying entries **1 - 10** of 14 in total

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Gene Ontology
4 iron, 4 sulfur cluster binding
DNA biosynthetic process
DNA repair
DNA replication proofreading
base-excision repair, gap-filling
iron-sulfur cluster binding
leading strand elongation
metal ion binding
nucleotide binding
nucleotide-excision repair, DNA gap filling

Displaying **all 10** entries
InterPro
DNA polymerase epsilon catalytic subunit
DNA polymerase epsilon, catalytic subunit A, C-terminal
DNA polymerase family B, thumb domain
DNA polymerase, palm domain superfamily
DNA-directed DNA polymerase, family B, exonuclease domain
DNA-directed DNA polymerase, family B, multifunctional domain
DNA-directed DNA polymerase, family B
DNA/RNA polymerase superfamily
Ribonuclease H superfamily
Ribonuclease H-like superfamily

Rhea

RHEA:22508

a 2'-deoxyribonucleoside 5'-triphosphate

diphosphate

Enzyme

PMID

Disease

Disease Ontology

Displaying **all 8** entries
DO ID	Disease Name	Source
DOID:0112182	mismatch repair cancer syndrome	Alliance of Genome Resources
DOID:1324	lung cancer	Alliance of Genome Resources
DOID:1380	endometrial cancer	Alliance of Genome Resources
DOID:218	ascending colon cancer	Alliance of Genome Resources
DOID:2871	endometrial carcinoma	Alliance of Genome Resources
DOID:3907	lung squamous cell carcinoma	Alliance of Genome Resources
DOID:3908	lung non-small cell carcinoma	Alliance of Genome Resources
DOID:9256	colorectal cancer	Alliance of Genome Resources

The Human Phenotype Ontology

Displaying entries **101 - 110** of **110** in total

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HPO ID	HPO Term
HP:0100031	Neoplasm of the thyroid gland
HP:0100255	Metaphyseal dysplasia
HP:0100273	Neoplasm of the colon
HP:0100571	Cardiac diverticulum
HP:0100576	Amaurosis fugax
HP:0100615	Ovarian neoplasm
HP:0100660	Dyskinesia
HP:0100743	Neoplasm of the rectum
HP:0100835	Benign neoplasm of the central nervous system
HP:0200063	Colorectal polyposis

Displaying **all 6** entries
Disease ID	Disease Name
OMIM:615083	colorectal cancer, susceptibility to, 12
OMIM:615139	facial dysmorphism-immunodeficiency-livedo-short stature syndrome
ORPHA:440437	familial colorectal cancer type X
ORPHA:85173	IMAGe syndrome
ORPHA:447877	Polymerase proofreading-related adenomatous polyposis
OMIM:618336	intrauterine growth retardation, metaphyseal dysplasia, adrenal hypoplasia congenita, genital anomalies, and immunodeficiency

PubChem Disease

MedGen Diseases

OMIM Phenotypes

KEGG Diseases

Gene-Disease-Co-Occurrences-in-Literature (PubChem)

Ortholog

Displaying entries **31 - 40** of 70 in total

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Species	Gene ID	Orthologous MAtrix
Ovis aries	101116176	SHEEP07251
Gorilla gorilla gorilla	101124678	GORGO05398
Tursiops truncatus	101321856	TURTR08348
Jaculus jaculus	101614825	JACJA20792
Mustela putorius furo	101691144	MUSPF01733
Heterocephalus glaber	101720520	HETGA23678
Melopsittacus undulatus	101881235	MELUD18531
Chrysemys picta bellii	101953633	CHRPI19374
Chinchilla lanigera	102019698	CHILA18369
Capra hircus	102174589	CAPHI07873

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

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Summary

External Links

Annotation

OrthoDB (Group)

PubChem Disease

International Collaboration

Acknowledgements