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Submissions

furin (paired basic amino acid cleaving enzyme)

Summary

Gene Symbol

Furin

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

54281

PubChem

54281

Alliance of Genome Resources

RGD:3274

Annotation

Keyword

Autocatalytic cleavage
Calcium
Cell membrane
Cleavage on pair of basic residues
Disulfide bond
Endosome
Glycoprotein
Golgi apparatus
Heparin-binding
Metal-binding
Phosphoprotein
Reference proteome
Repeat
Secreted
Serine protease
Signal
Transmembrane helix
Zymogen

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A6JCC0	Dibasic-processing enzyme Paired basic amino acid residue-cleaving enzyme
P23377	Dibasic-processing enzyme Paired basic amino acid residue-cleaving enzyme Prohormone convertase 3
G3V7I9	Dibasic-processing enzyme Paired basic amino acid residue-cleaving enzyme

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **6 - 10** of 24 in total

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GO Term	Evidence Code	PMID
blastocyst formation	IEA ISO
secretion by cell	IEA ISO
regulation of endopeptidase activity	IEA ISO
regulation of cholesterol transport	IEA ISO
cytokine precursor processing	IEA ISO ISS

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

amide metabolic process [inference]

peptide metabolic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

protein maturation

protein processing

signaling receptor ligand precursor processing [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

organic substance biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

hormone metabolic process [inference]

peptide hormone processing

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

protein maturation

protein processing

signaling receptor ligand precursor processing [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

protein maturation

protein processing

signaling receptor ligand precursor processing [inference]

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

protein maturation

protein processing

signaling receptor ligand precursor processing [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

organic substance biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

export from cell [inference]

secretion by cell

viral process [inference]

viral life cycle

multicellular organismal process [inference]

neurotrophin production [inference]

nerve growth factor production

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

blastocyst formation

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

secretion by cell

export from cell [inference]

secretion by cell

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta1 production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of cellular catabolic process [inference]

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of cellular catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of receptor catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of protein catabolic process

regulation of low-density lipoprotein particle receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of cellular catabolic process [inference]

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta1 production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of cellular catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of receptor catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of peptidase activity [inference]

regulation of endopeptidase activity

regulation of protein processing [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of protein catabolic process

regulation of low-density lipoprotein particle receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta1 production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of peptidase activity [inference]

regulation of endopeptidase activity

regulation of protein processing [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of protein catabolic process

regulation of low-density lipoprotein particle receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of receptor catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of peptidase activity [inference]

regulation of endopeptidase activity

regulation of protein processing [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of protein catabolic process

regulation of low-density lipoprotein particle receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of signaling [inference]

regulation of signal transduction

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

regulation of sterol transport [inference]

regulation of cholesterol transport

regulation of lipid localization [inference]

regulation of lipid transport [inference]

regulation of sterol transport [inference]

regulation of cholesterol transport

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of biological process involved in symbiotic interaction [inference]

modulation by symbiont of entry into host [inference]

regulation of viral entry into host cell [inference]

positive regulation of viral entry into host cell

positive regulation by symbiont of entry into host [inference]

positive regulation of viral entry into host cell

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of viral process [inference]

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of cellular response to transforming growth factor beta stimulus [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation by symbiont of entry into host [inference]

positive regulation of viral entry into host cell

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of cellular catabolic process [inference]

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of cellular catabolic process [inference]

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of neurotrophin production [inference]

negative regulation of nerve growth factor production

regulation of response to stimulus [inference]

regulation of signal transduction

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of cellular response to transforming growth factor beta stimulus [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of cellular response to transforming growth factor beta stimulus [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of cellular response to transforming growth factor beta stimulus [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

regulation of viral process [inference]

positive regulation of viral process [inference]

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

regulation of viral life cycle [inference]

regulation of viral entry into host cell [inference]

positive regulation of viral entry into host cell

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of cellular catabolic process [inference]

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta1 production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of cellular catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of receptor catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of cell motility [inference]

positive regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of cellular catabolic process [inference]

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta1 production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of neurotrophin production [inference]

negative regulation of neurotrophin production [inference]

negative regulation of nerve growth factor production

regulation of nerve growth factor production [inference]

negative regulation of nerve growth factor production

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of neurotrophin production [inference]

negative regulation of nerve growth factor production

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

regulation of molecular function [inference]

regulation of catalytic activity [inference]

regulation of hydrolase activity [inference]

regulation of peptidase activity [inference]

regulation of endopeptidase activity

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
Golgi cisterna	IDA	16541018
Golgi apparatus	IEA
endoplasmic reticulum membrane	IDA	16541018
plasma membrane	IEA
membrane raft	IEA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

membrane microdomain [inference]

membrane raft

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle [inference]

trans-Golgi network transport vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

trans-Golgi network transport vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle [inference]

trans-Golgi network transport vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

trans-Golgi network transport vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle [inference]

trans-Golgi network transport vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

trans-Golgi network transport vesicle

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
heparin binding	IEA ISO ISS
serine-type endopeptidase inhibitor activity	IEA ISO
metal ion binding	IEA
protease binding	IEA ISO
endopeptidase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

binding [inference]

protein binding [inference]

growth factor binding [inference]

neurotrophin binding [inference]

nerve growth factor binding

enzyme binding [inference]

protease binding

amide binding [inference]

peptide binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

heparan sulfate binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

heparan sulfate binding

cation binding [inference]

metal ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

sulfur compound binding [inference]

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

furin

Functional Category

K: Transcription
L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
hydrolase activity
peptide hormone processing
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Displaying entries **1 - 10** of 13 in total

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InterPro
Furin-like repeat
Galactose-binding-like domain superfamily
Growth factor receptor cysteine-rich domain superfamily
Kexin/furin catalytic domain
P domain
Peptidase S8, pro-domain superfamily
Peptidase S8, pro-domain
Peptidase S8, subtilisin, Asp-active site
Peptidase S8, subtilisin, His-active site
Peptidase S8, subtilisin, Ser-active site

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
Golgi cisterna	PMID:16541018
endoplasmic reticulum membrane	PMID:16541018

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:2349	arteriosclerosis	Alliance of Genome Resources

Ortholog

Displaying entries **81 - 90** of **115** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Marmota flaviventris	114078942	93162_0:00028e
Podarcis muralis	114584357		PODMU03811
Grammomys surdaster	114610281	491861_0:004459
Peromyscus leucopus	114696194	10041_0:000262
Echeneis naucrates	115040666		ECHNA23456
Salmo trutta	115167187		SALTR81267
Salmo trutta	115203143		SALTR81267
Gadus morhua	115559134		GADMO13188
Sparus aurata	115580139		SPAAU24991
Strigops habroptila	115612922		STRHB22911

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements