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Submissions

furin (paired basic amino acid cleaving enzyme)

Summary

Gene Symbol

Furin

Organism

Rattus norvegicus (Norway rat)

External Links

NCBI Gene

54281

PubChem

54281

Alliance of Genome Resources

RGD:3274

Annotation

Keyword

Autocatalytic cleavage
Calcium
Cell membrane
Cleavage on pair of basic residues
Disulfide bond
Endosome
Glycoprotein
Golgi apparatus
Heparin-binding
Metal-binding
Phosphoprotein
Reference proteome
Repeat
Secreted
Serine protease
Signal
Transmembrane helix
Zymogen

Proteins

Displaying **all 3** entries
UniProt	Protein Name
A6JCC0	Dibasic-processing enzyme Paired basic amino acid residue-cleaving enzyme
P23377	Dibasic-processing enzyme Paired basic amino acid residue-cleaving enzyme Prohormone convertase 3
G3V7I9	Dibasic-processing enzyme Paired basic amino acid residue-cleaving enzyme

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **16 - 20** of 24 in total

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GO Term	Evidence Code	PMID
negative regulation of nerve growth factor production	ISO
positive regulation of cell migration	IMP	15194465
negative regulation of low-density lipoprotein particle receptor catabolic process	IEA ISO
negative regulation of transforming growth factor beta1 production	IEA ISO
dibasic protein processing	IEA ISO

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

amide metabolic process [inference]

peptide metabolic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

protein maturation

protein processing

signaling receptor ligand precursor processing [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

biosynthetic process [inference]

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

organic substance biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

hormone metabolic process [inference]

peptide hormone processing

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

primary metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

protein maturation

protein processing

signaling receptor ligand precursor processing [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

protein maturation

protein processing

signaling receptor ligand precursor processing [inference]

organonitrogen compound metabolic process [inference]

peptide metabolic process [inference]

protein metabolic process [inference]

proteolysis

protein processing

signaling receptor ligand precursor processing [inference]

protein maturation

protein processing

signaling receptor ligand precursor processing [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

organic substance biosynthetic process [inference]

organonitrogen compound biosynthetic process [inference]

peptide biosynthetic process

cellular process [inference]

cellular metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

cellular biosynthetic process [inference]

cellular nitrogen compound biosynthetic process [inference]

amide biosynthetic process [inference]

peptide biosynthetic process

export from cell [inference]

secretion by cell

viral process [inference]

viral life cycle

multicellular organismal process [inference]

neurotrophin production [inference]

nerve growth factor production

developmental process [inference]

anatomical structure formation involved in morphogenesis [inference]

blastocyst formation

localization [inference]

establishment of localization [inference]

transport [inference]

secretion [inference]

secretion by cell

export from cell [inference]

secretion by cell

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of biosynthetic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta1 production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of cellular catabolic process [inference]

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of catabolic process [inference]

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of cellular catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of receptor catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of protein catabolic process

regulation of low-density lipoprotein particle receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of cellular catabolic process [inference]

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta1 production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of cellular catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of receptor catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of nitrogen compound metabolic process [inference]

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of peptidase activity [inference]

regulation of endopeptidase activity

regulation of protein processing [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of protein catabolic process

regulation of low-density lipoprotein particle receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of macromolecule metabolic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta1 production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of peptidase activity [inference]

regulation of endopeptidase activity

regulation of protein processing [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of protein catabolic process

regulation of low-density lipoprotein particle receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of receptor catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of primary metabolic process [inference]

regulation of protein metabolic process [inference]

regulation of proteolysis [inference]

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of peptidase activity [inference]

regulation of endopeptidase activity

regulation of protein processing [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of protein catabolic process

regulation of low-density lipoprotein particle receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of signaling [inference]

regulation of signal transduction

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

regulation of localization [inference]

regulation of transport [inference]

regulation of lipid transport [inference]

regulation of sterol transport [inference]

regulation of cholesterol transport

regulation of lipid localization [inference]

regulation of lipid transport [inference]

regulation of sterol transport [inference]

regulation of cholesterol transport

regulation of locomotion [inference]

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of biological process involved in symbiotic interaction [inference]

modulation by symbiont of entry into host [inference]

regulation of viral entry into host cell [inference]

positive regulation of viral entry into host cell

positive regulation by symbiont of entry into host [inference]

positive regulation of viral entry into host cell

positive regulation of biological process [inference]

positive regulation of signaling [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of locomotion [inference]

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of cell motility [inference]

positive regulation of cell migration

positive regulation of viral process [inference]

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of cellular response to transforming growth factor beta stimulus [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation by symbiont of entry into host [inference]

positive regulation of viral entry into host cell

negative regulation of biological process [inference]

negative regulation of metabolic process [inference]

negative regulation of biosynthetic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of macromolecule metabolic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of cellular catabolic process [inference]

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of nitrogen compound metabolic process [inference]

negative regulation of protein metabolic process [inference]

negative regulation of protein catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of proteolysis [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of cellular catabolic process [inference]

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of neurotrophin production [inference]

negative regulation of nerve growth factor production

regulation of response to stimulus [inference]

regulation of signal transduction

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of response to stimulus [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of cellular response to transforming growth factor beta stimulus [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

regulation of cellular response to growth factor stimulus [inference]

regulation of cellular response to transforming growth factor beta stimulus [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of cellular response to transforming growth factor beta stimulus [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

regulation of viral process [inference]

positive regulation of viral process [inference]

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

regulation of viral life cycle [inference]

regulation of viral entry into host cell [inference]

positive regulation of viral entry into host cell

positive regulation of viral life cycle [inference]

positive regulation of viral entry into host cell

regulation of cellular process [inference]

regulation of cell communication [inference]

regulation of signal transduction

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

regulation of transforming growth factor beta receptor signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

regulation of cellular metabolic process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of cellular catabolic process [inference]

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of cellular biosynthetic process [inference]

regulation of macromolecule biosynthetic process [inference]

regulation of gene expression [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta1 production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of protein maturation [inference]

regulation of protein processing [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

regulation of cellular catabolic process [inference]

negative regulation of cellular catabolic process [inference]

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of receptor catabolic process [inference]

regulation of low-density lipoprotein particle receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

positive regulation of cellular process [inference]

positive regulation of cell communication [inference]

positive regulation of signal transduction [inference]

positive regulation of transmembrane receptor protein serine/threonine kinase signaling pathway [inference]

positive regulation of transforming growth factor beta receptor signaling pathway

positive regulation of cell motility [inference]

positive regulation of cell migration

negative regulation of cellular process [inference]

negative regulation of cellular metabolic process [inference]

negative regulation of cellular biosynthetic process [inference]

negative regulation of macromolecule biosynthetic process [inference]

negative regulation of gene expression [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of protein maturation [inference]

negative regulation of protein processing [inference]

zymogen inhibition

negative regulation of cellular catabolic process [inference]

negative regulation of receptor catabolic process [inference]

negative regulation of low-density lipoprotein particle receptor catabolic process

regulation of cell motility [inference]

regulation of cell migration [inference]

positive regulation of cell migration

positive regulation of cell motility [inference]

positive regulation of cell migration

regulation of multicellular organismal process [inference]

regulation of cytokine production [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of transforming growth factor beta production [inference]

regulation of transforming growth factor beta1 production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

regulation of neurotrophin production [inference]

negative regulation of neurotrophin production [inference]

negative regulation of nerve growth factor production

regulation of nerve growth factor production [inference]

negative regulation of nerve growth factor production

negative regulation of multicellular organismal process [inference]

negative regulation of cytokine production [inference]

negative regulation of transforming growth factor beta production [inference]

negative regulation of transforming growth factor beta1 production

negative regulation of neurotrophin production [inference]

negative regulation of nerve growth factor production

regulation of biological quality [inference]

regulation of hormone levels [inference]

hormone metabolic process [inference]

peptide hormone processing

regulation of molecular function [inference]

regulation of catalytic activity [inference]

regulation of hydrolase activity [inference]

regulation of peptidase activity [inference]

regulation of endopeptidase activity

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
Golgi cisterna	IDA	16541018
Golgi apparatus	IEA
endoplasmic reticulum membrane	IDA	16541018
plasma membrane	IEA
membrane raft	IEA ISO

GO Hierarchy

cellular component

cellular anatomical entity [inference]

membrane [inference]

plasma membrane

organelle membrane [inference]

endoplasmic reticulum membrane

vesicle membrane [inference]

cytoplasmic vesicle membrane [inference]

endosome membrane

bounding membrane of organelle [inference]

membrane microdomain [inference]

membrane raft

organelle subcompartment [inference]

Golgi apparatus subcompartment [inference]

organelle [inference]

membrane-bounded organelle [inference]

vesicle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle [inference]

trans-Golgi network transport vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

trans-Golgi network transport vesicle

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle [inference]

trans-Golgi network transport vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

trans-Golgi network transport vesicle

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular vesicle [inference]

cytoplasmic vesicle [inference]

Golgi-associated vesicle [inference]

trans-Golgi network transport vesicle

transport vesicle [inference]

trans-Golgi network transport vesicle

coated vesicle [inference]

clathrin-coated vesicle [inference]

trans-Golgi network transport vesicle

Displaying entries **1 - 5** of 11 in total

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GO Term	Evidence Code	PMID
heparin binding	IEA ISO ISS
serine-type endopeptidase inhibitor activity	IEA ISO
metal ion binding	IEA
protease binding	IEA ISO
endopeptidase activity	ISO

GO Hierarchy

molecular function

catalytic activity [inference]

hydrolase activity [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

serine hydrolase activity [inference]

serine-type peptidase activity

serine-type endopeptidase activity

catalytic activity, acting on a protein [inference]

peptidase activity

endopeptidase activity

serine-type endopeptidase activity

serine-type peptidase activity

serine-type endopeptidase activity

binding [inference]

protein binding [inference]

growth factor binding [inference]

neurotrophin binding [inference]

nerve growth factor binding

enzyme binding [inference]

protease binding

amide binding [inference]

peptide binding

small molecule binding [inference]

organic acid binding [inference]

carboxylic acid binding [inference]

heparan sulfate binding

ion binding [inference]

anion binding [inference]

carboxylic acid binding [inference]

heparan sulfate binding

cation binding [inference]

metal ion binding

carbohydrate derivative binding [inference]

glycosaminoglycan binding [inference]

sulfur compound binding [inference]

molecular function regulator activity [inference]

enzyme regulator activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

peptidase regulator activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

endopeptidase regulator activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

molecular function inhibitor activity [inference]

enzyme inhibitor activity [inference]

peptidase inhibitor activity [inference]

endopeptidase inhibitor activity [inference]

serine-type endopeptidase inhibitor activity

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Rodentia

Group Name

furin

Functional Category

K: Transcription
L: Replication, recombination and repair
O: Posttranslational modification, protein turnover, chaperones
T: Signal transduction mechanisms

Displaying **all 5** entries
Gene Ontology
hydrolase activity
peptide hormone processing
proteolysis
serine-type endopeptidase activity
serine-type peptidase activity

Displaying entries **1 - 10** of 13 in total

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InterPro
Furin-like repeat
Galactose-binding-like domain superfamily
Growth factor receptor cysteine-rich domain superfamily
Kexin/furin catalytic domain
P domain
Peptidase S8, pro-domain superfamily
Peptidase S8, pro-domain
Peptidase S8, subtilisin, Asp-active site
Peptidase S8, subtilisin, His-active site
Peptidase S8, subtilisin, Ser-active site

Alliance of Genome Resources

Expression

Displaying **all 2** entries
Location	References
Golgi cisterna	PMID:16541018
endoplasmic reticulum membrane	PMID:16541018

Disease

Disease Ontology

Displaying 1 entry
DO ID	Disease Name	Source
DOID:2349	arteriosclerosis	Alliance of Genome Resources

Ortholog

Displaying entries **81 - 90** of **115** in total

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Species	Gene ID	OrthoDB	Orthologous MAtrix
Marmota flaviventris	114078942	93162_0:00028e
Podarcis muralis	114584357		PODMU03811
Grammomys surdaster	114610281	491861_0:004459
Peromyscus leucopus	114696194	10041_0:000262
Echeneis naucrates	115040666		ECHNA23456
Salmo trutta	115167187		SALTR81267
Salmo trutta	115203143		SALTR81267
Gadus morhua	115559134		GADMO13188
Sparus aurata	115580139		SPAAU24991
Strigops habroptila	115612922		STRHB22911

GlyTouCan

GlyComb

GlycoPOST

UniCarb-DR

LM-GlycoRepo

All Resources

Other Information

Tools

Search Tools

Summary

External Links

Annotation

OrthoDB (Group)

International Collaboration

Acknowledgements