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Guidelines

MIRAGE

DNA polymerase eta

Summary

Gene Symbol

POLH

Organism

Homo sapiens (human)

External Links

NCBI Gene

5429

PubChem

5429

Alliance of Genome Resources

HGNC:9181

Annotation

Keyword

3D-structure
Alternative splicing
DNA repair
DNA replication
DNA synthesis
DNA-binding
DNA-directed DNA polymerase
Direct protein sequencing
Disease variant
Isopeptide bond
Magnesium
Mutator protein
Nucleus
Proteomics identification
Reference proteome
Schiff base
Ubl conjugation
Xeroderma pigmentosum
Zinc-finger

Proteins

Displaying **all 2** entries
UniProt	Protein Name
Q9Y253	RAD30 homolog A Xeroderma pigmentosum variant type protein
B3KN75	RAD30 homolog A

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 10 in total

1

2

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GO Term	Evidence Code	PMID
DNA synthesis involved in DNA repair	IDA	17563354
DNA replication	IEA
DNA repair	TAS	10871396
regulation of DNA repair	TAS	10398605
pyrimidine dimer repair	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

pyrimidine dimer repair

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

pyrimidine dimer repair

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

pyrimidine dimer repair

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

pyrimidine dimer repair

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

pyrimidine dimer repair

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

pyrimidine dimer repair

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

pyrimidine dimer repair

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

pyrimidine dimer repair

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

pyrimidine dimer repair

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

nucleic acid metabolic process [inference]

DNA metabolic process [inference]

DNA replication

pyrimidine dimer repair

postreplication repair [inference]

translesion synthesis [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

DNA biosynthetic process [inference]

DNA synthesis involved in DNA repair

translesion synthesis [inference]

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

pyrimidine dimer repair

postreplication repair [inference]

translesion synthesis [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-C

response to stimulus [inference]

response to stress [inference]

cellular response to stress [inference]

DNA damage response [inference]

pyrimidine dimer repair

postreplication repair [inference]

translesion synthesis [inference]

response to abiotic stimulus [inference]

response to radiation

response to light stimulus [inference]

response to UV [inference]

response to UV-C

cellular response to UV-C

cellular response to UV [inference]

cellular response to UV-C

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-C

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-C

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-C

cellular response to stimulus [inference]

cellular response to stress [inference]

DNA damage response [inference]

pyrimidine dimer repair

postreplication repair [inference]

translesion synthesis [inference]

cellular response to environmental stimulus [inference]

cellular response to abiotic stimulus [inference]

cellular response to radiation [inference]

cellular response to light stimulus [inference]

cellular response to UV [inference]

cellular response to UV-C

biological regulation [inference]

regulation of biological process [inference]

regulation of metabolic process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA repair

regulation of nitrogen compound metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA repair

regulation of macromolecule metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA repair

regulation of primary metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA repair

regulation of response to stimulus [inference]

regulation of response to stress [inference]

regulation of cellular response to stress [inference]

regulation of DNA repair

regulation of cellular process [inference]

regulation of cellular metabolic process [inference]

regulation of nucleobase-containing compound metabolic process [inference]

regulation of DNA metabolic process [inference]

regulation of DNA repair

regulation of cellular response to stress [inference]

regulation of DNA repair

Displaying entry **6 - 6** of 6 in total

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GO Term	Evidence Code	PMID
site of double-strand break	IBA

GO Hierarchy

cellular component

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

site of DNA damage [inference]

site of double-strand break

Displaying entries **1 - 5** of 6 in total

1

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GO Term	Evidence Code	PMID
damaged DNA binding	IEA
DNA-directed DNA polymerase activity	TAS
DNA-directed DNA polymerase activity	IBA
protein binding	IPI	16763556 17304240 24485656
zinc ion binding	IEA

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

DNA polymerase activity [inference]

DNA-directed DNA polymerase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on DNA [inference]

DNA polymerase activity [inference]

DNA-directed DNA polymerase activity

binding [inference]

protein binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

organic cyclic compound binding [inference]

nucleic acid binding [inference]

DNA binding [inference]

damaged DNA binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

DNA polymerase

Functional Category

C: Energy production and conversion
L: Replication, recombination and repair

Displaying **all 6** entries
Gene Ontology
DNA repair
damaged DNA binding
error-prone translesion synthesis
metal ion binding
response to radiation
transferase activity

Displaying **all 6** entries
InterPro
DNA polymerase eta, ubiquitin-binding zinc finger
DNA polymerase, Y-family, little finger domain superfamily
DNA polymerase, Y-family, little finger domain
DNA/RNA polymerase superfamily
Reverse transcriptase/Diguanylate cyclase domain
UmuC domain

Disease

Disease Ontology

Displaying **all 2** entries
DO ID	Disease Name	Source
DOID:0050671	female breast cancer	Alliance of Genome Resources
DOID:0110847	xeroderma pigmentosum variant type	Alliance of Genome Resources

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Partly supported by NIH Common Fund Grant #1U01GM125267-01

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Last updated: December 8, 2025