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RNA polymerase II subunit B

Summary

Gene Symbol

POLR2B

Organism

Homo sapiens (human)

External Links

NCBI Gene

5431

PubChem

5431

Alliance of Genome Resources

HGNC:9188

Annotation

Keyword

3D-structure
DNA-directed RNA polymerase
Hydrolase
Magnesium
Methylation
Nucleotidyltransferase
Nucleus
Phosphoprotein
Proteomics identification
RNA-directed RNA polymerase
Reference proteome
Zinc-finger

Proteins

Displaying **all 4** entries
UniProt	Protein Name
B4DH29
C9J2Y9
P30876	3'-5' exoribonuclease DNA-directed RNA polymerase II 140 kDa polypeptide DNA-directed RNA polymerase II subunit B RNA polymerase II subunit 2 RNA polymerase II subunit B2 RNA-directed RNA polymerase II subunit RPB2
B4DHJ3

Annotation information from UniProt.

Gene Ontology (GO)

Displaying entries **1 - 5** of 9 in total

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GO Term	Evidence Code	PMID
transcription by RNA polymerase IV	IEA
transcription by RNA polymerase V	IEA
RNA-templated transcription	IEA
transcription, RNA-templated	IEA
transcription by RNA polymerase I	IEA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

mitochondrial transcription

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

mitochondrial transcription

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

mitochondrial transcription

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

mitochondrial transcription

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

mitochondrial transcription

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

mitochondrial transcription

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

mitochondrial transcription

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

mitochondrial transcription

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

mitochondrial transcription

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

mitochondrial RNA metabolic process [inference]

mitochondrial transcription

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

transcription, RNA-templated

DNA-templated transcription [inference]

Displaying entries **1 - 5** of 8 in total

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GO Term	Evidence Code	PMID
chromosome, telomeric region	IDA	24270157
nucleus	IDA	9852112
nucleoplasm	TAS
nucleoplasm	IDA
RNA polymerase II, core complex	IDA	9852112

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

nuclear DNA-directed RNA polymerase complex [inference]

RNA polymerase II, core complex

intracellular protein-containing complex [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex [inference]

nuclear DNA-directed RNA polymerase complex [inference]

RNA polymerase II, core complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex [inference]

nuclear DNA-directed RNA polymerase complex [inference]

RNA polymerase II, core complex

cellular anatomical entity [inference]

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

chromosomal region [inference]

chromosome, telomeric region

Displaying entries **1 - 5** of 13 in total

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GO Term	Evidence Code	PMID
DNA binding	IEA
chromatin binding	IEA
RNA binding	HDA	22658674 22681889
DNA-directed 5'-3' RNA polymerase activity	ISS
DNA-directed 5'-3' RNA polymerase activity	IDA	23748380 9852112

GO Hierarchy

molecular function

catalytic activity [inference]

transferase activity [inference]

transferase activity, transferring phosphorus-containing groups [inference]

nucleotidyltransferase activity [inference]

RNA polymerase activity [inference]

5'-3' RNA polymerase activity [inference]

hydrolase activity

catalytic activity, acting on a nucleic acid [inference]

catalytic activity, acting on RNA [inference]

RNA polymerase activity [inference]

5'-3' RNA polymerase activity [inference]

binding [inference]

protein binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleoside binding [inference]

ribonucleoside binding

ion binding [inference]

cation binding [inference]

metal ion binding

transition metal ion binding [inference]

zinc ion binding

protein-containing complex binding [inference]

chromatin binding

organic cyclic compound binding [inference]

nucleoside binding [inference]

ribonucleoside binding

nucleic acid binding [inference]

carbohydrate derivative binding [inference]

nucleoside binding [inference]

ribonucleoside binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

dna-directed RNA polymerase

Functional Category

H: Coenzyme transport and metabolism
J: Translation, ribosomal structure and biogenesis
K: Transcription
T: Signal transduction mechanisms

Displaying **all 4** entries
Gene Ontology
metal ion binding
nucleotidyltransferase activity
ribonucleoside binding
transferase activity

Displaying entries **1 - 10** of 12 in total

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InterPro
DNA-directed RNA polymerase, subunit 2, hybrid-binding domain superfamily
DNA-directed RNA polymerase, subunit 2, hybrid-binding domain
DNA-directed RNA polymerase, subunit 2
RNA polymerase Rpb2, OB-fold
RNA polymerase Rpb2, domain 2 superfamily
RNA polymerase Rpb2, domain 2
RNA polymerase Rpb2, domain 3
RNA polymerase Rpb2, domain 4
RNA polymerase Rpb2, domain 5
RNA polymerase Rpb2, domain 7

Ortholog

Displaying entries **1 - 10** of 85 in total

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	5431	Xenbase:XB-GENE-1012874
Mus musculus	231329		MOUSE44519
Rattus norvegicus	289561		RATNO07777
Sus scrofa	397001		PIGXX33727
Pan troglodytes	461305		PANTR33906
Canis lupus familiaris	475152		CANLF03419
Bos taurus	538184		BOVIN31543
Macaca mulatta	694664		MACMU37541
Monodelphis domestica	100012197		MONDO26509
Equus caballus	100053708		HORSE31881

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