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Guidelines

MIRAGE

RNA polymerase II subunit D

Summary

Gene Symbol

POLR2D

Organism

Homo sapiens (human)

External Links

NCBI Gene

5433

PubChem

5433

Alliance of Genome Resources

HGNC:9191

Annotation

Keyword

3D-structure
DNA-directed RNA polymerase
Nucleus
Reference proteome

Proteins

Displaying 1 entry
UniProt	Protein Name
O15514	DNA-directed RNA polymerase II subunit D RNA polymerase II 16 kDa subunit

Annotation information from UniProt.

Gene Ontology (GO)

Displaying **all 3** entries
GO Term	Evidence Code	PMID
transcription by RNA polymerase II	IDA	9852112
transcription by RNA polymerase II	IMP	9528765
transcription initiation at RNA polymerase II promoter	IBA

GO Hierarchy

biological process

metabolic process [inference]

nitrogen compound metabolic process [inference]

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

biosynthetic process [inference]

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

primary metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

organic substance metabolic process [inference]

macromolecule metabolic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

organic cyclic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

organic substance biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

organic cyclic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

cellular process [inference]

cellular metabolic process [inference]

cellular aromatic compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

cellular nitrogen compound metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

cellular biosynthetic process [inference]

macromolecule biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

aromatic compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

cellular nitrogen compound biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

heterocycle metabolic process [inference]

nucleobase-containing compound metabolic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

nucleic acid metabolic process [inference]

RNA metabolic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

heterocycle biosynthetic process [inference]

nucleobase-containing compound biosynthetic process [inference]

RNA biosynthetic process [inference]

DNA-templated transcription [inference]

transcription by RNA polymerase II

DNA-templated transcription initiation [inference]

transcription initiation at RNA polymerase II promoter

Displaying entries **1 - 5** of 7 in total

1

2

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GO Term	Evidence Code	PMID
nucleus	IDA	9852112
nucleoplasm	TAS
nucleoplasm	IDA
RNA polymerase II, core complex	IDA	9528765 9852112
RNA polymerase II, core complex	IBA

GO Hierarchy

cellular component

protein-containing complex [inference]

nuclear protein-containing complex [inference]

nuclear DNA-directed RNA polymerase complex [inference]

RNA polymerase II, core complex

intracellular protein-containing complex [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex [inference]

nuclear DNA-directed RNA polymerase complex [inference]

RNA polymerase II, core complex

catalytic complex [inference]

transferase complex [inference]

transferase complex, transferring phosphorus-containing groups [inference]

RNA polymerase complex [inference]

DNA-directed RNA polymerase complex [inference]

nuclear DNA-directed RNA polymerase complex [inference]

RNA polymerase II, core complex

cellular anatomical entity [inference]

nuclear body [inference]

nuclear speck

organelle [inference]

membrane-bounded organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

intracellular organelle [inference]

intracellular membrane-bounded organelle [inference]

nucleus

Displaying **all 3** entries
GO Term	Evidence Code	PMID
nucleotide binding	IEA
protein binding	IPI	21988832 24981860 28514442 33961781 9528765
translation initiation factor binding	IBA

GO Hierarchy

molecular function

binding [inference]

protein binding

translation initiation factor binding

small molecule binding [inference]

heterocyclic compound binding [inference]

nucleotide binding

organic cyclic compound binding [inference]

nucleoside phosphate binding [inference]

nucleotide binding

Gene Ontology information from NCBI Gene and UniProt.

OrthoDB (Group)

Group level

Eukaryota

Group Name

RNA polymerase

Functional Category

G: Carbohydrate transport and metabolism
K: Transcription
O: Posttranslational modification, protein turnover, chaperones

Displaying **all 5** entries
Gene Ontology
cellular metabolic process
nucleotide binding
recruitment of 3'-end processing factors to RNA polymerase II holoenzyme complex
transcription initiation at RNA polymerase II promoter
translation initiation factor binding

Displaying **all 5** entries
InterPro
DNA-directed RNA polymerase II subunit Rpb4-like
HRDC-like superfamily
RNA polymerase Rpb4/RPC9, core
RNA polymerase subunit Rpb4/RPC9
Rpb4/RPC9 superfamily

Ortholog

Displaying entries **1 - 10** of 77 in total

1

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Species	Gene ID	Alliance of Genome Resources	Orthologous MAtrix
Xenopus tropicalis	5433	Xenbase:XB-GENE-1004238
Mus musculus	69241		MOUSE23439
Rattus norvegicus	364834		RATNO13362
Danio rerio	436588		DANRE29465
Canis lupus familiaris	483863		CANLF06316
Bos taurus	617422		BOVIN23844
Macaca mulatta	699945		MACMU05611
Monodelphis domestica	100018533		MONDO24206
Equus caballus	100069214		HORSE13091
Salmo salar	100286604		SALSA75092

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Last updated: December 8, 2025